著者

荻野 敏 原田 保 坂口 喜清 柳 英博 丹生 真理子 仙波 治 入船 盛弘 田矢 直三 野入 輝久 坂本 邦彦 荻野 仁

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.91, no.2, pp.199-204, 1998-02-01 (Released:2011-11-04)

参考文献数

7

被引用文献数

4 6

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Treatment of tinnitus is often difficult. In this study, we evaluated the effectiveness of a Chinese medicine, Gosha-jinki-gan, for the treatment of tinnitus. Forty-two cases, comprising a total of 58 ears, received Gosha-jinki-gan at a dose of 7.5 g a day for at least 4 weeks. Efficacy was evaluated on the basis of changes in symptoms before and after treatment. In total, twenty-seven out of 58 ears (46.6%) improved. The final improvement rate was higher in the group with hearing loss than in the group without hearing loss. It was also greater in the group without pre-treatment than in the group with pre-treatment, however, co-treatment did not influence the improvement rate. No adverse reactions were evident. From these results, it was thought that Gosha-jinki-gan might be useful in the treatment of tinnitus.

著者

荻野 敏 入船 盛弘 有本 啓恵 岩田 伸子 荻野 仁 菊守 寛 瀬尾 律 竹田 真理子 玉城 晶子 馬場 謙治

出版者

耳鼻と臨床会

雑誌

耳鼻と臨床 (ISSN:04477227)

巻号頁・発行日

vol.52, no.4, pp.247-251, 2006-07-20 (Released:2013-05-10)

参考文献数

5

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73名のスギ花粉症患者を対象に、スギ、ヒノキ花粉の飛散量にかなりの変動が認められた2001年1月からの3年間、特異的IgE抗体価の経年的変化を検討した。スギ、ヒノキの大量飛散によりスギ、ヒノキ特異的IgE抗体価は翌年の1月には有意に上昇し、飛散少量年の翌年には有意に低下する経年的な変化が見られた。それに対し、HD、カモガヤでは同様の変動は見られなかった。この変動は年齢にかかわらず認められた。以上のように、特異的IgE抗体価はアレルゲンの曝露量に極めて大きな影響を受け、スギ、ヒノキ花粉の大量飛散後には、特異的IgE産生が亢進し、翌年まで高抗体価を持続することから、少量飛散年と予測されても被曝量を減らすことを考慮した生活指導が必要と思われた。

著者

荻野 仁 松永 亨

出版者

耳鼻と臨床会

雑誌

耳鼻と臨床 (ISSN:04477227)

巻号頁・発行日

vol.31, no.3, pp.503-508, 1985-05-20 (Released:2013-05-10)

参考文献数

20

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Coenzyme Q10 is said to increase the efficiency of oxygen utilization and ATP production in ischemic tissue. The present study was undertaken to determine the blood levels and clinical effects of Coenzyme Q10 in 83 patients with vertigo. The mean blood level of Coenzyme Q10 in 83 patients with vertigo was 0.61±0.27 μg/ml, which was lower than the normal value of 0.81±0.34 μg/ml (p<0.01). Blood levels of Coenzyme Q10 were significantly lower in patients with sudden deafness, central dizziness and vertigo than in those with MÉNIÈRE's disease. The time course of vertigo was followed in the MÉNIÈRES's disease patients in whom blood levels of Coenzyme Q10 could be determined at various times. As a result, it was found that there was a correlation between blood levels of Coenzyme Q10 and vertigo. Briefly, the mean blood level of Coenzyme Q10 was 0.72±0.22 μg/ml during remission, while it was 0.43±0.19 μg/ml when the patients were conscious of vertigo. After 2 weeks of treatment the clinical effects of Coenzyme Q10 on vertigo were determined in a group of 14 patients on Coenzyme Q10 (Neuquinon) alone, 30-90mg/day, and in a group of 23 patients on combination therapy with Coenzyme Q10 (Neuquinon), 60-90mg/day, and an cerebral metabolic activator. The drug effect evaluations were in principle made on the basis of changes in subjective and objective symptoms at the end of treatment period. The rate of effectiveness was 90% for patients on combination therapy and 35.7% for those on single therapy with Coenzyme Q10. This result suggests that the transport of Coenzyme Q10 to tissue is enhanced when it is combined with an excitometabolic cardiovascular drug and that they pharmacologically produce a synergistic effect with each other.

著者

荻野 仁

出版者

医学書院

雑誌

精神看護 (ISSN:13432761)

巻号頁・発行日

vol.6, no.4, pp.70-74, 2003-07