12 0 0 0 OA 酸化マグネシウム製剤とアムロジピンベシル酸塩製剤間における 同時簡易懸濁時に生じる配合変化の相違
- 著者
- 峯垣 哲也 湯月 翔太 伯井 理恵子 藤井 尚子 濱田 美輝 若林 未稀 辻本 雅之 西口 工司
- 出版者
- Japanese Society of Drug Informatics
- 雑誌
- 医薬品情報学 (ISSN:13451464)
- 巻号頁・発行日
- vol.19, no.3, pp.97-103, 2017 (Released:2017-12-27)
- 参考文献数
- 8
- 被引用文献数
- 1
Objective: A simple suspension method in our previous study indicated that the amount of amlodipine recovered from a Norvasc®OD tablet was decreased by simultaneous suspension of a Magmitt®tablet containing magnesium oxide, due to the increase in pH. However, it is still unclear whether this incompatibility arises in both brand name and generic tablets because the tablets may have different additives and mechanical properties. In this study, we evaluated the degree of incompatibility between Magmitt®tablets and a range of amlodipine besylate tablets, including original and generic versions.Methods: Twenty-four kinds of amlodipine besylate tablets were used. Magmitt®and amlodipine besylate tablets were suspended in warm water (55°C), and 10 min or 2 h later, the amount of amlodipine in the suspension was measured by HPLC-UV.Results: For almost all tested tablets, the recovery amount of amlodipine was significantly decreased in the presence of Magmitt®, and the amount recovered varied significantly between the types of amlodipine tablets. However, Magmitt®tablet had little effect on the recovery of amlodipine from two specific brand tablets.Conclusions: An incompatibility between Magmitt®and most types of amlodipine besylate could be observed, although the degree of incompatibility depended on the brand of amlodipine. These results are useful for the proper use of drugs.
10 0 0 0 赤の力学 : 色をめぐる人間と自然と社会の構造
- 著者
- 藤井 尚子
- 巻号頁・発行日
- 2007-03
1 0 0 0 OA 有松・鳴海絞りを用いた脱着容易性と回復意欲に資する病衣デザインの学際的研究
本研究は、入院患者が着用する衣服である「病衣」について、名古屋市立大学附属病院の看護部や化学療法部の医師と連携し学際的研究チームを構成し、現状の病衣の実状調査をふまえ「脱着容易性」と「患者の回復意欲の向上」に重点をおき、名古屋市の伝統技法「有松・鳴海絞り」の伸縮性を応用する病衣デザインの開発と研究を進めた。成果は以下のとおりである。(1) 国内外における病衣および療養環境の先行研究調査に基づく中長期療養型病衣の提案(2) 容易な脱着性を実現する病衣の基本的構造およびデザイン要件の抽出「有松・鳴海絞り」を活用した病衣プロタイプの製作および検証(3) 病衣デザインの公的発表