著者

郡司 敦子 郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.28, no.3, pp.109-116, 2009-12-01 (Released:2010-04-16)

参考文献数

39

被引用文献数

1

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Acetaminophen is an antipyretic and analgesic drug that has a long history of 100 years or more and has been adopted in the WHO Model List of Essential Drugs in the category of non-opioids and non-steroidal anti-inflammatory medicines. In Japan, the analgesic effects of acetaminophen have not been sufficiently recognized, and NSAIDs have been used in the treatment of pain, even though acetaminophen is the first-choice analgesic worldwide.Since acetaminophen, which is different from NSAIDs, does not inhibit the activity of COX-1 and COX-2, the risk of developing the 3 well-known adverse reactions of NSAIDs, peptic ulcer and gastrointestinal hemorrhage, renal dysfunction, and hemorrhage and platelet dysfunction, is very low. Aspirin is known to induce asthma and Reye's syndrome, however, acetaminophen is scarcely associated with these adverse reactions and can be used for treatment of viral diseases such as chicken pox and influenza. The safety of acetaminophen in pregnant women and elderly patients has been confirmed, and the position of acetaminophen as the first-choice analgesic drug has been established worldwide. In Japan, on the other hand, the effect of acetaminophen has not been sufficiently recognized due to the small doses (single dose, 300-500 mg; daily dose, 900-1500 mg/day) compared to other nations (single dose, 1,000 mg; daily dose, 4000-6000 mg/day). Further, the precautions for use indicated in the package insert of acetaminophen are the same as that indicated for NSAIDs; this may be a possible reason why acetaminophen has been misunderstood to be a kind of anti-inflammatory medication (NSAIDs) in Japan.From above-mentioned viewpoint, the dosage of acetaminophen and expression of the precautions in packaging insertion should be reconsidered. The dosage of acetaminophen as a nonprescription drug should also be reconsidered because the dosage in OTC is further lower than that of the prescription drug. It is expected that when a more reliable analgesic effect is obtained by the administration of a higher dosage of acetaminophen and a more accurate profile of its safety is recognized, this drug will become the first-choice analgesic in Japan.

著者

郡司 敦子 郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.28, no.3, pp.109-116, 2009-12-01

参考文献数

39

---

Acetaminophen is an antipyretic and analgesic drug that has a long history of 100 years or more and has been adopted in the WHO Model List of Essential Drugs in the category of non-opioids and non-steroidal anti-inflammatory medicines. In Japan, the analgesic effects of acetaminophen have not been sufficiently recognized, and NSAIDs have been used in the treatment of pain, even though acetaminophen is the first-choice analgesic worldwide.<br>Since acetaminophen, which is different from NSAIDs, does not inhibit the activity of COX-1 and COX-2, the risk of developing the 3 well-known adverse reactions of NSAIDs, peptic ulcer and gastrointestinal hemorrhage, renal dysfunction, and hemorrhage and platelet dysfunction, is very low. Aspirin is known to induce asthma and Reye's syndrome, however, acetaminophen is scarcely associated with these adverse reactions and can be used for treatment of viral diseases such as chicken pox and influenza. The safety of acetaminophen in pregnant women and elderly patients has been confirmed, and the position of acetaminophen as the first-choice analgesic drug has been established worldwide. In Japan, on the other hand, the effect of acetaminophen has not been sufficiently recognized due to the small doses (single dose, 300-500 mg; daily dose, 900-1500 mg/day) compared to other nations (single dose, 1,000 mg; daily dose, 4000-6000 mg/day). Further, the precautions for use indicated in the package insert of acetaminophen are the same as that indicated for NSAIDs; this may be a possible reason why acetaminophen has been misunderstood to be a kind of anti-inflammatory medication (NSAIDs) in Japan.<br>From above-mentioned viewpoint, the dosage of acetaminophen and expression of the precautions in packaging insertion should be reconsidered. The dosage of acetaminophen as a nonprescription drug should also be reconsidered because the dosage in OTC is further lower than that of the prescription drug. It is expected that when a more reliable analgesic effect is obtained by the administration of a higher dosage of acetaminophen and a more accurate profile of its safety is recognized, this drug will become the first-choice analgesic in Japan.

著者

郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.29, no.1, pp.1-8, 2010-04-01

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Many epidemiological studies have shown that the prevention of dental caries by fluoride is a basic and indispensable method to maintain and improve dental health. However, the countermeasures for maintenance of dental health and implementation of preventive programs for caries are still not satisfactory in Japan. In developed countries, it is thought that the prevalence of water fluoridation and use of fluoride-containing dentifrices are the primary factors responsible for the remarkable decrease in the prevalence of dental caries in children. Topical application of fluorides, especially fluoride mouth rinsing, has an extremely important role in Japan as compared with various other countries, because systemic application of fluorides, such as water fluoridation and use of fluoride tablets are not yet available in Japan. However, fluoride mouth rinsing has not become prevalent on a nationwide scale. Therefore, it is hoped that fluoride mouth rinsing will be enforced in more kindergartens, elementary schools, and junior high schools to contribute to the improvement of dental health in the future.

著者

郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.29, no.1, pp.1-8, 2010-04-01 (Released:2010-08-20)

参考文献数

39

---

Many epidemiological studies have shown that the prevention of dental caries by fluoride is a basic and indispensable method to maintain and improve dental health. However, the countermeasures for maintenance of dental health and implementation of preventive programs for caries are still not satisfactory in Japan. In developed countries, it is thought that the prevalence of water fluoridation and use of fluoride-containing dentifrices are the primary factors responsible for the remarkable decrease in the prevalence of dental caries in children. Topical application of fluorides, especially fluoride mouth rinsing, has an extremely important role in Japan as compared with various other countries, because systemic application of fluorides, such as water fluoridation and use of fluoride tablets are not yet available in Japan. However, fluoride mouth rinsing has not become prevalent on a nationwide scale. Therefore, it is hoped that fluoride mouth rinsing will be enforced in more kindergartens, elementary schools, and junior high schools to contribute to the improvement of dental health in the future.