- 著者
-
郷 信広
- 出版者
- 一般社団法人 日本生物物理学会
- 雑誌
- 生物物理 (ISSN:05824052)
- 巻号頁・発行日
- vol.61, no.1, pp.005-011, 2021 (Released:2021-01-29)
- 参考文献数
- 13
The Snake Cube Puzzle made of a linear array of 27 cubes and its modified and extended versions are used as theoretical models to study the mechanism of folding of proteins into their sequence-specific native three-dimensional structures. The problem of protein folding is reviewed very briefly by comparing it with the problem of genetic code. It is stressed that the folding process is basically a physical phenomenon. The consistency principle advocated nearly 40 years ago to explain the folding mechanism is briefly reviewed. The result obtained by using the models provides a semi-quantitative manifestation of the consistency principle.