2 0 0 0 OA 歯周病菌の病原性を不活化する麹菌由来物質の構造と機能
歯周病の主な原因菌はPorpyromonas gingivalisであり、本菌は毒素ジンジパインをくることで歯周組織を破壊する。予備的実験の結果, Aepergillus oryzae S-03株を脱脂大豆を用いて個体培養すると, 「毒素ジンジパイン」に対する阻害物質を産生することを発見した。 この度の本研究を通じて, 脱脂大豆を用いてA. oryzae S-03を培養し得られた麹由来のジンジパイン阻害剤の分子量は, 3, 000~10,000であり, クロロホルムや酢酸エチルには溶解しないが, 水には可溶であった。また, 100℃, 10 minの熱処理でも全く阻害活性は失われなかった。
1 0 0 0 OA 磁気センサ型指タッピング装置の再現性評価
- 著者
- 佐野 佑子 神鳥 明彦 島 圭介 田村 康裕 高木 寛 辻 敏夫 野田 正文 東川 史子 横江 勝 佐古田 三郎
- 出版者
- The Society of Instrument and Control Engineers
- 雑誌
- 計測自動制御学会論文集 (ISSN:04534654)
- 巻号頁・発行日
- vol.47, no.6, pp.272-281, 2011 (Released:2011-12-19)
- 参考文献数
- 13
- 被引用文献数
- 1 2
We tested the repeatability of a finger tapping device with magnetic sensors to determine its reliability. This device, which was developed to assist in the diagnosis of movement disorders such as Parkinson's disease (PD) and strokes, measures the distance between the first and index fingers during finger tapping movements (opening and closing the fingers repeatedly). We evaluated three types of repeatability based on ICC (interclass correlation coefficient) and Welch's test (test for equal means in a oneway layout): repeatability when measured at different times, when using different devices, and when using different measurers. We calculated these three types for three finger tapping tasks on both hands for 21 characteristics calculated from finger tapping waveforms. Results demonstrated that the repeatability when using different devices is high regardless of the task or hand. The repeatability when measuring at different times and when using different measurers is high at some tasks, but not all. One of the finger tapping tasks (finger tapping movement with the largest amplitude and highest velocity), which is used in a conventional PD diagnosis method (UPDRS), does not have enough repeatability, while other tasks show high repeatability. Results also showed that five characteristics have the highest repeatability (ICC ≥ 0.5 or significance probability of Welch's test ≥ 5% in all tasks): “total moving distance,” “average of local minimum acceleration in opening motion,” “average of local minimum acceleration in closing motion,” “average of local maximum distance” and “average of local minimum velocity”. These results clearly demonstrate the strong repeatability of this device and lead to more precise diagnosis of movement disorders.