著者

木村 佳人 山下 幸政 三上 栄 小野 洋嗣 板井 良輔 松本 善秀 山田 聡 高田 真理子 住友 靖彦

出版者

一般財団法人 日本消化器病学会

雑誌

日本消化器病学会雑誌 (ISSN:04466586)

巻号頁・発行日

vol.110, no.2, pp.271-281, 2013 (Released:2013-02-05)

参考文献数

9

被引用文献数

1

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症例は48歳,男性.血液検査で肝胆道系酵素と好酸球数の上昇を認めた.画像検査上は当初明らかな胆管病変を認めず,肝生検でも特徴的な所見に乏しかったが,何らかの自己免疫疾患を疑いステロイドを投与した.一旦は軽快したがステロイド減量にともない再増悪を認め,画像上も胆管に原発性硬化性胆管炎類似の広狭不整像が広範に出現した.再度肝生検を施行したところ門脈域に密な好酸球浸潤を認め,好酸球性胆管炎と診断した.

著者

長井 孝紀 田中 滋康 高田 真理

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.29, no.3, pp.154-160, 2004-05-01 (Released:2011-03-04)

参考文献数

20

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Amphibians regulate the osmotic and ionic composition of their body fluids by water and ion transport across their skin. When dehydrated, desert toads press down the pelvic region of ventral skin on moist surfaces to achieve maximal water absorption. Aquaporins (AQP) are trans-membrane proteins permeable to water. We cloned three isoforms of AQP (AQP-h1, -h2, -h3) in tissues of tree frogs. AQP-h3 was abundantly expressed in the pelvic region of ventral skin, facilitating water absorption across the skin. Antibodies to AQP-h3 labeled the cell membrane of the granulosum cells in the skin. AQP-h3 was progressively expressed during metamorphosis of larval frogs. Expression of AQP-h3 was facilitated by and diuretic hormone, argine vasotocin. Collectively, AQP-h3 is a molecule to play a positive role in water absorption across the amphibian skin. In bullfrogs short circuit current across the skin was suppressed by amiloride, a blocker for epithelial Na+ channel (ENaC), showing that transport of sodium ions occurs through ENaC. Na+ transport increased in parallel with metamorphosis of the tadpole. In cultured skins of the tadpole Na+ transport was facilitated by aldosterone, but counteracted by prolactin. Such counteraction seemed to be removed by thyroid hormone (T3) during metamorphosis to adapt a terrestrial environment.