著者

Senta Gewalt Shqipdona Lahu Gjin Ndrepepa Costanza Pellegrini Isabell Bernlochner Franz-Josef Neumann Maurizio Menichelli Tanja Morath Bernhard Witzenbichler Jochen Wöhrle Katharina Hoppe Gert Richardt Karl-Ludwig Laugwitz Heribert Schunkert Adnan Kastrati Stefanie Schüpke Katharina Mayer

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.62776, (Released:2021-04-16)

参考文献数

31

被引用文献数

3

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Aim: Sex-specific analyses of direct head-to-head comparisons between newer P2Y12 inhibitors are limited. This study was conducted to assess the efficacy and safety of ticagrelor versus prasugrel in women and men with acute coronary syndromes (ACS) planned for an invasive strategy. Methods: This pre-specified analysis of the ISAR-REACT 5 trial included 956 women and 3,062 men with ACS randomly assigned to either ticagrelor or prasugrel. The primary endpoint was the 12-month incidence of death, myocardial infarction, or stroke; the safety endpoint was the 12-month incidence of bleeding (type 3–5 according to the Bleeding Academic Research Consortium [BARC]). Results: The primary endpoint occurred in 42 women (8.9%) in the ticagrelor group and 39 women (8.3%) in the prasugrel group (hazard ratio [HR]=1.10, 95% confidence interval [CI] 0.71–1.70, P=0.657) and in 142 men (9.4%) in the ticagrelor group and 98 men (6.5%) in the prasugrel group (HR=1.47 [1.13–1.90], P=0.004; P for interaction [Pint]=0.275). BARC type 3–5 bleeding occurred in 36 women (9.7%) in the ticagrelor group and 34 women (9.7%) in the prasugrel group (HR=1.04 [0.65–1.67], P=0.856) and in 59 men in the ticagrelor group (4.4%) and 46 men (3.6%) in the prasugrel group (HR=1.24 [0.85–1.83], P=0.266; Pint=0.571). Conclusions: Although there was no significant interaction between sex and treatment effect of study drugs, the superior efficacy of prasugrel was more evident among men. No difference in bleeding between the two study groups was seen for both women and men.

著者

Ehimen C Aneni Chukwuemeka U Osondu Javier De La Cruz Seth S Martin Michael J Blaha Adnan Younus Theodore Feldman Arthur S Agatston Emir Veledar Khurram Nasir

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.40741, (Released:2018-09-14)

参考文献数

27

被引用文献数

16

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Aims: There is limited knowledge about the association of lipoprotein particles and markers of coronary atherosclerosis such as coronary artery calcification (CAC) in relatively young high-risk persons. This study examines the association of lipoprotein subfractions and CAC in high cardiometabolic risk individuals.Methods: The study presents analysis from baseline data of a randomized trial targeted at high-risk workers. Employees of Baptist Health South Florida with metabolic syndrome or diabetes were recruited. At baseline, all 182 participants had lipoprotein subfraction analysis using the ion mobility technique and participants above 35 years (N=170) had CAC test done. Principal components (PC) were computed for the combination of lipoprotein subclasses. Multiple bootstrapped regression analyses (BSA) were conducted to assess the relationship between lipoprotein subfractions and CAC.Results: The study population (N=170) was largely female (84%) with a mean age of 58 years. Three PCs accounted for 88% variation in the sample. PC2, with main contributions from VLDL particles in the positive direction and large LDL particles in the negative direction was associated with a 22% increase in CAC odds (P value <0.05 in 100% of BSA). PC3, with main contributions from HDL lipoprotein particles in the positive direction and small/medium LDL and large IDL particles in the negative direction, was associated with a 9% reduction in CAC odds (P<0.05 in 88% of BSA). PC1, which had approximately even contributions from HDL, LDL, IDL and VLDL lipoprotein subfractions in the positive direction, was not associated with CAC.Conclusion: In a relatively young but high-risk population, a lipoprotein profile predominated by triglyceride-rich lipoproteins was associated with increased risk of CAC, while one predominated by HDL lipoproteins offered modest protection. Lipoprotein sub-fraction analysis may help to further discriminate patients who require more intensive cardiovascular work-up and treatment.

著者

Cui-Ling Ji Adnan Nomi Bin Li Cheng Shen Bing-Chun Song Jin-Guo Zhang

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.18-422, (Released:2019-04-25)

参考文献数

33

被引用文献数

6

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Fractalkine has been reported to play an important role in the pathophysiology of various cardiovascular disorders. This research aims to study the change of soluble fractalkine (sFKN) in plasma level of patients with chronic heart failure (CHF) and evaluate its prognostic value.A total of 96 patients with CHF and 45 healthy subjects were included in this study. The plasma levels of sFKN, brain natriuretic peptide (BNP), and Interleukin-18 (IL-18) were determined by ELISA kits when they were first admitted to the hospital. Left ventricular ejection fraction (LVEF) was measured by echocardiogram. Rehospitalization status within 1 year after the first hospitalization was also recorded.The plasma levels of sFKN, BNP, and IL-18 in patients with CHF were significantly higher than in the control group (P < 0.05). The concentrations of sFKN and BNP were increased with the severity of heart failure classified by NYHA classification (P < 0.05). There were no statistical differences among all CHF subgroups classified by etiology (P > 0.05). Plasma sFKN level in CHF group was positively correlated with BNP (r = 0.441, P < 0.001) and IL-18 (r = 0.592, P < 0.001). Receiver operating characteristic curve analysis showed that area under the curve values of FKN, BNP, and IL-18 were 0.885 (95%CI: 0.810 to 0.960, P < 0.001), 0.889 (95%CI: 0.842 to 0.956, P < 0.001), and 0.878 (95%CI: 0.801-0.954, P < 0.001), respectively. The concentrations of sFKN and BNP were increased in patients readmitted more than once within 1 year (P < 0.05).

著者

Wenqing Zhu Xiaoguang Luo Atif Adnan Peifu Yu Siyi Zhang Zhixin Huo Qin Xu Hao Pang

出版者

The Genetics Society of Japan

雑誌

Genes & Genetic Systems (ISSN:13417568)

巻号頁・発行日

pp.17-00038, (Released:2018-03-30)

被引用文献数

6

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Genome-wide association studies have reported numerous candidate loci associated with Parkinson's disease (PD). NUCKS1 and INPP5K are two such candidate loci, although they have rarely been reported in Asian populations. To explore these potential genes for PD susceptibility, we investigated the association between PD and two SNPs, rs823114 and rs1109303, located on the NUCKS1 and INPP5K genes, respectively, in the Han population of northern China. We genotyped the two SNPs using the multiplex PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) technique. A total of 685 subjects including 322 sporadic PD patients and 363 healthy controls were recruited from the population. After Bonferroni correction, our results suggested that there was a significant association of a minor allele (G) in rs823114 with reduced risk of PD development (P = 0.017, OR = 0.768, 95%CI = 0.618 - 0.955), and the difference in genotypes between the PD patients and healthy controls was significant under the dominant model (GA+GG vs. AA). After stratification by gender, males had a lower risk than females (P = 0.008, OR = 0.666, 95%CI = 0.495 - 0.898). However, the distribution of genotype frequency exhibited no significant differences between the PD and control groups (P > 0.025) in INPP5K rs1109303 (P = 0.048, OR = 0.806, 95%CI = 0.650 - 0.998). We conclude that NUCKS1 rs823114 indicates a decreased risk of susceptibility to PD and shows a male genetic distribution bias in the Han Chinese population.

著者

Adnan Malik Husain Tanveer Ali Sajjad

出版者

Leena and Luna International

雑誌

Asian journal of management sciences & education (ISSN:21868441)

巻号頁・発行日

vol.4, no.2, pp.146-150, 2015-04

著者

Bahar Ahmed Adnan Jathlan Al-Rehaily Tawfeq Abdullah Al-Howiriny Khaled Abdelatee El-Sayed Mohammad Shamim Ahmad

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.26, no.4, pp.462-467, 2003 (Released:2003-04-01)

参考文献数

17

被引用文献数

21 48

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Five iridoid glycosides, including the two new compounds scropolioside-D2 (1) and harpagoside-B (2), were isolated from the aerial parts of Scrophularia deserti DEL (Scrophulariaceae). Their structures were elucidated on the basis of spectral data to be 6-O-[2″,4″-di-O-acetyl-3″-O-trans-cinnamoyl)-α-L-rhamnopyranosyl]-8α-hydroxymethyl-1α,5β,6α,7α,9β-pentahydro-7(8)-epoxy-2-oxaind-3-ene-1-O-β-D-glucopyranoside-6′-O-acetate (1) and 5-O-β-hydroxy-8-O-β-trans-cinnamoyl-8α-methyl-1,6,7,9-tetrahydro-2-oxaind-3-ene-1-O-β-D-glucopyranoside (2), respectively. In addition, three more iridoid glycosides, scropolioside-D (3), koelzioside (4), and 8-O-acetyl-harpagide (5), were also isolated and characterized from this source. The biological activity and the structure activity relationship of the compounds were also studied, and scropolioside-D (3) and harpagoside-B (2) were found to possess significant antidiabetic and antiinflammatory activity, respectively.

著者

Nilgun GUVENER Neslihan Bascil TUTUNCU Sule AKCAY Fusun EYUBOGLU Adnan GOKCEL

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.50, no.6, pp.663-667, 2003 (Released:2003-12-27)

参考文献数

15

被引用文献数

16 32

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The present study has been conducted to quantify and compare the capacity of gas exchange in patients with type 2 diabetes mellitus (DM) and healthy controls and also to investigate the effects of various factors on alveolar capillary permeability. A total of 37 subjects, 25 patients with DM and 12 healthy controls were recruited for the study. All the participants were evaluated with simple spirometric tests and simple breath carbonmonoxide (CO) diffusion test (DLCO). The ratio of DLCO value to the alveolar ventilation (VA) was used to assess alveolar membrane permeability. Diabetic patients were also evaluated in detail with respect to degenerative diabetic complications including the presence of microalbuminuria, advanced nephropathy, sensorial and autonomic neuropathy, retinopathy, hypertension and macrovascular disease. The results of simple spirometric tests which determined lung capacity were similar in the diabetic patients and the healthy controls. Ratio of DLCO/VA, which determines alveolar membrane permeability, revealed statistically significant decline in pulmonary gas exchange in the diabetic group (p: 0.037). Pearson correlation analysis revealed statistically significant correlation between duration of diabetes mellitus, age and urinary albumin excretion with DLCO/VA values (Pearson: -0.726, p: 0.001; Pearson: -0.438, p: 0.036; Pearson: -0.472, p: 0.023 respectively). This study demonstrated the decreased alveolar gas exchange capacity in diabetic patients compared with healthy controls. Detrimental effects of DM on alveolar capillaries were found to be correlated with age, duration of DM and urinary albumin excretion. Microalbuminuria was the only significant predictor of DLCO/VA.

著者

Adnan

巻号頁・発行日

2012

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Thesis (Ph. D. in Engineering)--University of Tsukuba, (A), no. 6303, 2012.7.25

著者

ADNAN SATO Mitsuhisa

出版者

電子情報通信学会

雑誌

IEICE transactions on information and systems (ISSN:09168532)

巻号頁・発行日

vol.E95-D, no.6, pp.1565-1576, 2012-06

被引用文献数

2

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Lazy-task creation is an efficient method of overcoming the overhead of the grain-size problem in parallel computing. Work stealing is an effective load balancing strategy for parallel computing. In this paper, we present dynamic work stealing strategies in a lazy-task creation technique for efficient fine-grain task scheduling. The basic idea is to control load balancing granularity depending on the number of task parents in a stack. The dynamic-length strategy of work stealing uses run-time information, which is information on the load of the victim, to determine the number of tasks that a thief is allowed to steal. We compare it with the bottommost first work stealing strategy used in StackThread/MP, and the fixed-length strategy of work stealing, where a thief requests to steal a fixed number of tasks, as well as other multithreaded frameworks such as Cilk and OpenMP task implementations. The experiments show that the dynamic-length strategy of work stealing performs well in irregular workloads such as in UTS benchmarks, as well as in regular workloads such as Fibonacci, Strassen's matrix multiplication, FFT, and Sparse-LU factorization. The dynamic-length strategy works better than the fixed-length strategy because it is more flexible than the latter; this strategy can avoid load imbalance due to overstealing.

著者

山本 禎紀 藤田 正範 坂本 竜一 古本 史 安保 佳洋 SULONG Adnan 安保 佳洋

出版者

日本家畜管理学会

雑誌

日本家畜管理学会誌 (ISSN:13421131)

巻号頁・発行日

vol.32, no.1, pp.1-9, 1996-07-23

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乳量の高い泌乳牛に対して、一時的に飼料摂取量を変化させた場合の熱産生量と体温調節性生理反応の応答性について、秋の常温期と夏の高温期に調べた。熱産生量はTDN摂取に応じて直ちに反応し、常温期での平均熱産生量は明らかに摂取量に応じて変化した。しかし、高温期の熱産生量は常温期に比べて明らかに高く、摂取レベル間の差も常温期ほど明らかではなかった。飼料摂取と気温上昇に伴う体温調節性生理反応の発現順序は、直腸温と体幹部体表温の上昇につづく呼吸数の増加であり、放熱機能の稼動には、体熱量の増加や体温の上昇が必要不可欠であると考えられた。飼料摂取量と各反応レベルとは密接に関係しており、給与飼料量の制限によって体温の上昇をある程度抑制できるものと思われた。なお、心拍数と熱産生量との関係から、平均心拍数を用いた精度の高い熱産生量推定式を提示した(Y=-0.27+0.552X、r=0.95、PE(Sy・x/y^^-)=4.4%、Y=熱産生量(kJ/kg^<0.75>h、X=心拍数(/min))。日本家畜管理学会誌、32(1) : 1-9.1996.1995年10月9日受付1996年2月22日受理