著者

Takafumi Hasegawa Naoto Sugeno Akio Kikuchi Toru Baba Masashi Aoki

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.242, no.1, pp.63-76, 2017 (Released:2017-05-25)

参考文献数

145

被引用文献数

10 23

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Parkinson’s disease (PD) is the second most common neurodegenerative disorder that is characterized by progressive movement disability and a variety of non-motor symptoms. The neuropathology of PD consists of the loss of dopaminergic neurons in the midbrain and the appearance of neuronal inclusions called Lewy bodies, which contain insoluble α-synuclein, a relatively small protein originally identified in association with synaptic vesicles in the presynaptic nerve terminals. Drugs that replenish dopamine can partly alleviate the motor symptoms, but they do not cure the disease itself. Therefore, there is an urgent need for disease modification in terms of the delay or prevention of neurodegeneration. Recent advances in genetic and biochemical studies have provided unifying conceptual frameworks of the pathogenesis of PD. Particularly, membrane trafficking has aroused special attention as an initiator or enhancer of the neurodegenerative process that leads to PD. Defects in the cellular trafficking pathway result in synaptic dysfunction and the accumulation of misfolded α-synuclein. Likewise, changes in intracellular sorting and degradation profoundly influence the cellular trafficking of misfolded proteins, thereby facilitating the cell-to-cell spreading of hazardous α-synuclein species in a prion-like manner. Here, we will review our current knowledge of the functional roles of membrane trafficking in PD and will discuss how this cellular process could induce or facilitate the functional and pathological alterations in this disease.

著者

菊池 章夫 Akio KIKUCHI 岩手県立大学社会福祉学部 FACULTY OF SOCIAL WELFARE IWATE PREFECTURAL UNIVERSITY

出版者

岩手県立大学社会福祉学部

雑誌

岩手県立大学社会福祉学部紀要 = Bulletin of the Faculty of Social Welfare, Iwate Prefectural University (ISSN:13448528)

巻号頁・発行日

vol.5, no.2, pp.35-40, 2003-03-30

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An examination on the reliabilities and validities of a Japanese form of the Test of Self-Conscious Affect-3 (short form) (Tangney and Dearing, 2002) was done using by the responses of 123 university students. Cronbach's α-coefficients of this form were slightly low, especially in Detachment (D) and Externalization (E) scales. Although the score of Prosocial Behavior Scale (PSB: Kikuchi, 1998) highly related to those of Guilt (G) scale of TOSCA-3, and Empathic Concern (EC) and Perspective Taking (PT) scales of Interpersonal Reactivity Index (IRI: Davis, 1998), significant relationships were not found, as expected, between the score of PSB and those of Shame (S) scale in TOSCA-3 and Personal Distress (PD) scale in IRI.