著者

Beaney Michael Bo Chen Nakatogawa Koji

出版者

Graduate School of Letters, Hokkaido University

雑誌

Journal of the Graduate School of Letters (ISSN:18808832)

巻号頁・発行日

vol.5, pp.1-25, 2010-03

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The interview begins with an outline of Gottlob Frege's life, academic career and the reception of his ideas by later philosophers such as Bertrand Russell and Ludwig Wittgenstein. Frege's main contributions to logic and philosophy are summarized, and the key ideas of his three main books - Begriffsschrift, Die Grundlagen der Arithmetik and Grundgesetze der Arithmetik - are explained. Particular attention is paid to Frege's fundamental claim that "a statement of number contains an assertion about a concept" and to the 'Cantor-Hume Principle',which play a central role in his logicist project - the attempt to show that arithmetic can be reduced to logic. Also discussed are three of Frege's important essays, which elucidate his view of concepts as functions and his distinctions between concept and object and between 'Sinn' and 'Bedeutung'. Here particular attention is paid to problems concerning his notion of an extension of a concept (or more generally, his notion of a value-range of a function), the translation of 'Bedeutung', and the application of the distinction between Sinn and Bedeutung to different kinds of linguistic expressions. Recent developments of Frege's ideas by, for example, 'neo-logicists' are mentioned, and there is also discussion of Frege's conception of 'thoughts'. The interview ends with some remarks on certain influences on Frege, such as from neo-Kantianism, and some suggestions for further reading.

著者

Fei Li Rong Tang Ling-Bo Chen Ke-Sheng Zhang Xiao-Ping Huang Chang-Qing Deng

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.40, no.5, pp.598-609, 2017-05-01 (Released:2017-05-01)

参考文献数

27

被引用文献数

20

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Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis. Following establishment of the model, mice were administered with Astragalus (6.00 g·kg−1), Angelica (3.00 g·kg−1), and combinations of Astragalus and Angelica at different ratios, including 10 : 1 (Astragalus 9.81 g·kg−1+Angelica 0.98 g·kg−1), 5 : 1 (Astragalus 9.00 g·kg−1+Angelica 1.80 g·kg−1), 2 : 1 (Astragalus 7.71 g·kg−1+Angelica 3.08 g·kg−1), 1 : 1 (Astragalus 5.40 g·kg−1+Angelica 5.40 g·kg−1), 1 : 2.5 (Astragalus 3.08 g·kg−1+Angelica 7.71 g·kg−1), 1 : 5 (Astragalus 1.80 g·kg−1+Angelica 9.00 g·kg−1), and 1 : 10 (Astragalus 0.98 g·kg−1+Angelica 9.81 g·kg−1). Our results suggested that Astragalus mixed with Angelica synergistically promoted hematopoiesis best when the combination ratio of Astragalus and Angelica was 1 : 1, 1 : 2.5 or 1 : 5; moreover, the effect of Angelica was greater than that of Astragalus. The potential mechanisms of the combinations of Astragalus and Angelica that promote hematopoiesis include the dissolution of the effective components, promoting the synthesis and secretion of hematopoietic growth factor (HGF) and the proliferation of hematopoietic progenitor cells (HPCs).

著者

WILLIAMSON Timothy BO Chen Nakatogawa Koji

出版者

科学基礎論学会

雑誌

Annals of the Japan Association for Philosophy of Science (ISSN:04530691)

巻号頁・発行日

vol.18, pp.57-87, 2009-11-15

著者

Patrick John Rudewicz Qin Yue Ying-Bo Chen Suzanna Clark Peiyin Wang William Mallet Dylan Daniel Grazia Piizzi Cristina Nieto-Oberhuber

出版者

日本プロテオーム学会(日本ヒトプロテオーム機構)

雑誌

日本プロテオーム学会大会要旨集 日本プロテオーム学会2018年大会(MSP2018)

巻号頁・発行日

pp.288, 2018 (Released:2019-03-01)