著者

Peng Sun Zhiqiang Wang Bo Li Shanjiang Chen

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.64, no.6, pp.1002-1009, 2023-11-30 (Released:2023-11-30)

参考文献数

47

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The relationship between dietary magnesium intake and the risk of stroke is controversial. This study aimed to examine the association of dietary magnesium intake with the risk of stroke among American adults.The relationship between dietary magnesium intake and the risk of stroke was analyzed using the National Health and Nutrition Examination Survey (NHANES) 2007-2018 data with 29,653 adults. The amount of magnesium from the diet was assessed by two 24-hour dietary recalls. Stroke outcomes were defined using the results of the self-reported questionnaires. The association between dietary magnesium intake and the risk of stroke was evaluated using logistic regression models and restricted cubic spline.In our study, an inverse association between dietary magnesium intake and the risk of stroke was found. For the highest versus lowest quartile of dietary magnesium intake, the multivariate-adjusted odds ratio (95% confidence interval) of stroke was 0.56 (0.36-0.86). The magnesium intake of women was negatively associated with stroke risk, but this negative association was not found in men. Then, the inverse association was statistically significant among the 40-59 year-old group. The results from the dose-response analysis show a linear relationship between dietary magnesium intake and the risk of stroke.Dietary magnesium intake was inversely associated with the risk of stroke, especially in women. Therefore, our study emphasizes the importance of appropriately increasing dietary magnesium intake.

著者

Wei Bo LI

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.53, no.2, pp.72-99, 2018 (Released:2018-09-13)

参考文献数

132

被引用文献数

5

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Fifty-five years after discovery of x-rays by Wilhelm Conrad Röntgen in 1895, International Commission on Radiological Protection (ICRP) established a committee on permission internal exposure. Natural and man-made radionuclides can enter human body, cause damage effect and lead to health risk; on the other hand, radionuclides can cure cancers and other non-cancer diseases by irradiating the malignant cells and tissues. The radiation doses delivered to the tissues and organs are inevitable to assess risk or to judge the benefit of application of radiation on humans. In this article, basic methodology for dose assessment of internally deposited radionuclides is reviewed. After brief introduction of interactions and effects of radiation, the biokinetic models developed by ICRP for incorporation of radionuclides in humans are described. Then, the dosimetric formula generalized by ICRP and Committee on Medical Internal Radiation Dose (MIRD) is presented. Treatment of decay products and uncertainty analysis in internal dosimetry are especially addressed. Moreover, applications of internal dosimetry in radiation protection, internal exposure monitoring, radon inhalation dosimetry and nuclear medicine are presented with several calculation examples. At last, the future perspective of internal dosimetry is discussed. In an appendix basic internal dosimetric quantities are provided.

著者

Wei WANG Shaozhong LUO Yaping CHEN Bo LI Masao HATTORI

出版者

(社)日本分析化学会

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.32, no.6, pp.705-707, 2016-06-10 (Released:2016-06-10)

参考文献数

15

被引用文献数

7

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An effective separation and simultaneous determination of corynoxeine and its metabolites using high-performance liquid chromatography with tandem mass spectrometry was developed and validated. The method was applied to pharmacokinetics and in vivo distribution investigations in rats after oral (0.105 mmol kg−1) and intravenous (0.0105 mmol kg−1) doses of corynoxeine. Its brain uptake index was of 3.08 × 10−11 mol g−1 at 3 h and 3.75 × 10−11 mol g−1 at 74 min after oral and intravenous doses, respectively.