著者
YUKIFLTMI NAKATA KISAKU KAMIYA
出版者
The Japanese Circulation Society
雑誌
JAPANESE CIRCULATION JOURNAL (ISSN:00471828)
巻号頁・発行日
vol.34, no.11, pp.1029-1034, 1970-12-31 (Released:2008-04-14)
参考文献数
22
被引用文献数
9 11

It has been reported that disturbance of the vasa vasorum changes permeability, flow of tissue fluid, and nutrition in the vascular wall and becomes a cause of fat deposition in these regions. In this experiment, relation between fat deposition and disturbance of the vasa vasorum was studied using new method obstructing the vasa vasorum alone.
著者
Mafumi Owa Kazunori Aizawa Nobuyuki Urasawa Hiroyuki Ichinose Kazuya Yamamoto Koji Karasawa Mitsuru Kagoshima Jun Koyama Shu-ichi Ikeda
出版者
日本循環器学会
雑誌
JAPANESE CIRCULATION JOURNAL (ISSN:00471828)
巻号頁・発行日
vol.65, no.4, pp.349-352, 2001 (Released:2001-06-01)
参考文献数
13
被引用文献数
66 90

Four patients had the clinical features of `ampulla cardiomyopathy', consisting of acute-onset transient left ventricular apical akinesis with basal normokinesis, normal coronary angiogram, ST-segment elevation and subsequent giant T wave inversion, which mimicked acute coronary syndrome, the onset of which occurred shortly after extreme mental stress. Myocardial necrosis was minimal, although 2 patients showed elevated serum catecholamine levels in the acute phase. Each patient underwent serial cardiac radionuclide single-photon emission computed tomography of myocardial functional sympathetic innervation, fatty acid metabolism and perfusion using I-123-metaiodobenzyl-guanidine (MIBG), I-123-β-metyl-iodophenyl pentadecanoic acid (BMIPP) and thallium-201 (201Tl), respectively. In the acute phase, MIBG and BMIPP imaging showed an uptake defect in the apical region, whereas 201Tl uptake was mildly decreased. When assessed semi-quantitatively, the MIBG images had higher defect scores from the acute phase throughout the year of observation compared with BMIPP, and 201Tl. These observations suggest that the primary cause of ampulla cardiomyopathy is related to a disturbance of the cardiac sympathetic innervation. (Jpn Circ J 2001; 65: 349 - 352)
著者
OKAMOTO KOZO AOKI KYUZO
出版者
社団法人日本循環器学会
雑誌
Japanese circulation journal (ISSN:00471828)
巻号頁・発行日
vol.27, no.3, pp.282-293, 1963-03-20
被引用文献数
61

A male rat with spontaneously high systolic blood pressures of 150 to 175 mmHg persisting for more than one month and a female rat with blood pressures slighty above the average, 130 to 140 mmHg, were selected from among 68 Wistar strain rats in normal condition and mated to obtain F_1 rats. Of these F_1 rats, males and females with hypertension (blood pressure exceeding 150 mmHg) persisting for more than a month (mostly over 2 months) were mated to produce F_2 rats. The procedure was repeated to obtain F_3, F_4, F_5 and F_6 rats totaliag 380 animals. The weights and blood pressures (by the tail-water-plethysmographic method) were measured once weekly biginning at 4 weeks of age, and the results can be summarized as follows : 1. In body weight, the F rats showed little difference from the normal controls. 2. The blood pressures of F rats rose with age and from generation to generation, increasing significantly above those of normotensive controls of the same age after 20 weeks of age among female F_1, after 15 weeks among male F_1 and also male and female F_2, and after 10 weeks among all F_3 to F_6 rats. E. g., the average systolic blood pressure of F_5 at 25 weeks of age was 206+__-18.5 mmHg in the male and 193+__-20.5 mmHg in female rats. The blood pressures of normotensive controls remained at 131 to 136 mmHg in the male and 130 to 135 mmHg in female rats after 10 weeks of age. 3. Many F rats showed spontaneous hypertension. The incidence of the spontaneous occurrence of hypertension increased, and the development of hypertension occurred at younger ages from generation to generation. All of the F_3 to F_6, rats developed spontaneous hypertension within 15 weeks of age. Severe hypertension with blood pressures exceeding 200 mmHg began to observed among F_2. The incidence of such severe hypertension increased with each generation, so that among male animals it inceased from only 9% in F_2 to 35% in F_3, 42% in F_4, and 56% in F_5, and in female animals from 3% in F_2, 16% in F_3, 33% in F_4, and 37% in F_5. The authors have named this Wistar strain of rats with spontaneous occurrence of hypertension as "spontaneously hypertensive rats (Okamoto-Aoki)". 4. The blood pressures of β-line rats from parents with very high blood pressures were significantly higher than among α-line rats from parents with moderately high blood pressures at the same age. 5. There was no difference in the blood pressures of offsprings resulting from inbreeding and those from cross breeding. The male blood pressure averaged about 10.6 mmHg above the female value in spontaneous hypertension, and hypertension developed at lower ages in the male. 6. It is a question for future study whether the spontaneous hypertension induced in rats in this Study is comparable in characteristics with essential hypertension in man.
著者
Shirato Kunio KANAZAWA MASAHARU ISHIKAWA KEN NAKAJIMA TOSHIYUKI TAKISHIMA TAMOTSU
出版者
社団法人日本循環器学会
雑誌
Japanese circulation journal (ISSN:00471828)
巻号頁・発行日
vol.46, no.1, pp.113-123, 1982-01-20
被引用文献数
1

We studied the effect of the pericardium on the end-diastolic pressure-segment length (P-L) relation in volume loading (Experiment I) and in acute ischemia (Experiment II). Experiment I: In 6 open chest dogs, segment length of left and right ventricles were measured using ultrasonic crystals during blood infusion. Drawing end-diastolic pressure (P, on ordinate) against segment length (L, on abscissa), the P-L curve with pericardium positioned upward compared to that without pericardium. The slopes (b) of the exponential curve (P = ae^<bL>) with pericardium were steeper than those without pericardium in both ventricles. The difference between the slopes with and without pericardium was significantly larger in the right ventricle (RV, 0.30 ± 0. 10, mean ± SEM) than in the left ventricle (LV, 0.05 ± 0.02, p < 0.05). These results show that the pericardium inhibits the distensibility of the free wall more in RV than in LV, and enhances a mechanical coupling of both ventricles during volume overload. Experiment II: In 8 open chest dogs, segment lengths of ischemic and non-ischemic regions in LV were measured after left circumflex coronary occlusion. When the segment lengths and LV pressure became stable, a pericardiectomy was performed. After the pericardiectomy, whereas heart rate and LV systolic pressure did not change, end-diastolic segment length in the ischemic region further lengthened (12.0 0.2 to 12.5 0.2 mm, p < 0.01) and that in the non-ischemic region did not change despite the concomitant fall in LV end-diastolic pressure (EDP, 11.9 0.6 to 9.8 0.6 mmHg, p < 0.01). These results suggest that the pericardium alters the LV end-diastolic pressure-volume relation and is one of the factors contributing to an increase in LVEDP during acute ischemia.