著者

Mayumi Ikeuchi Naoki Hino Aya Nishisyo Mariko Aoyama Miyuki Kanematsu Hiroaki Inoue Soichiro Sasa Tomohiro Inui Naoki Miyamoto Kazumasa Okumura Hiromitsu Takizawa

出版者

The University of Tokushima Faculty of Medicine

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.69, no.1.2, pp.107-111, 2022 (Released:2022-04-22)

参考文献数

21

被引用文献数

1

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Purpose:Drug-induced interstitial pneumonia (DIP) that occurs during chemotherapy for breast cancer is a rare but a serious adverse event. Treatments of DIP requires interruption of breast cancer treatment, which may affect the patient’s prognosis. However, there are few reports which discuss DIP during breast cancer treatments. Purpose of this report is to make clear how DIP occurred and influenced breast cancer treatment in our hospital. Patients and Methods:A total of 74 patients who started perioperative chemotherapy in Tokushima Municipal Hospital for breast cancer from January 2019 to December 2020 were evaluated for DIP. Patients’ and tumors’ characteristics, and regimens which caused DIP were investigated. The clinical courses of the DIP patients were also followed up. Results:Twelve of the 74 patients developed DIP. All 12 patients had histories of cyclophosphamide administration;however, the causative drug could not be determined. Ten of the 12 patients were treated with steroids, and all the patients recovered ultimately from the interstitial pneumonia. While chemotherapy was administered in six patients after mild DIP, no relapse of pneumonia was observed. Conclusion:DIP during perioperative chemotherapy for breast cancer was resolved with appropriate treatment. Patients were able to resume breast cancer treatment with minimal interruption. J. Med. Invest. 69 : 107-111, February, 2022

著者

EricS.Fukuda Hiroaki Inoue Takashi Takenaka Dahoo Kim Tsunaki Sadahisa Tetsuya Asai Masato Motomura

出版者

Information Processing Society of Japan

雑誌

Journal of Information Processing (ISSN:18826652)

巻号頁・発行日

vol.23, no.2, pp.143-152, 2015-03-15

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Memcached has been widely accepted as a technology to improve the response speed of web servers by caching data on DRAMs in distributed servers. Because of its importance, the acceleration of memcached has been studied on various platforms. Among them, FPGA looks the most attractive platform to run memcached, and several research groups have tried to obtain a much higher performance than that of CPU out of it. The difficulty encountered there, however, is how to manage large-sized memory (gigabytes of DRAMs) from memcached hardware built in an FPGA. Some groups are trying to solve this problem by using an embedded CPU for memory allocation and another group is employing an SSD. Unlike other approaches that try to replace memcached itself on FPGAs, our approach augments the software memcached running on the host CPU by caching its data and some operations at the FPGA-equipped network interface card (NIC) mounted on the server. The locality of memcached data enables the FPGA NIC to have a fairly high hit rate with a smaller memory. In this paper, we describe the architecture of the proposed NIC cache, and evaluate the effectiveness with a standard key-value store (KVS) benchmarking tool. Our evaluation shows that our system is effective if the workload has temporal locality but does not handle workloads well without such a characteristic. We further propose methods to overcome this problem and evaluate them. As a result, we estimate that the latency improved by up to 3.5 times over software memcached running on a high performance CPU.Memcached has been widely accepted as a technology to improve the response speed of web servers by caching data on DRAMs in distributed servers. Because of its importance, the acceleration of memcached has been studied on various platforms. Among them, FPGA looks the most attractive platform to run memcached, and several research groups have tried to obtain a much higher performance than that of CPU out of it. The difficulty encountered there, however, is how to manage large-sized memory (gigabytes of DRAMs) from memcached hardware built in an FPGA. Some groups are trying to solve this problem by using an embedded CPU for memory allocation and another group is employing an SSD. Unlike other approaches that try to replace memcached itself on FPGAs, our approach augments the software memcached running on the host CPU by caching its data and some operations at the FPGA-equipped network interface card (NIC) mounted on the server. The locality of memcached data enables the FPGA NIC to have a fairly high hit rate with a smaller memory. In this paper, we describe the architecture of the proposed NIC cache, and evaluate the effectiveness with a standard key-value store (KVS) benchmarking tool. Our evaluation shows that our system is effective if the workload has temporal locality but does not handle workloads well without such a characteristic. We further propose methods to overcome this problem and evaluate them. As a result, we estimate that the latency improved by up to 3.5 times over software memcached running on a high performance CPU.

著者

Yusuke Kamiyoshihara Takuya Nakamura Yasuharu Itagaki Shinichi Asada Takashi Aoki Shinji Mizuno Keiichi Watanabe Hiroaki Inoue Akira Tateishi

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.OKD-133, (Released:2018-02-01)

被引用文献数

2

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Actinidin is a major protein contained in kiwifruit (Actinidia spp.). While uptake of actinidin is beneficial to help gastric protein digestion with cysteine protease activity, the protein is also recognized as a major elicitor of allergy which can induce tingling in the oral cavity and occasionally severe anaphylactic reactions. Given that consumption of fresh kiwifruit has increased globally, development of Actinidia cultivars with lower level of actinidin is required to reduce the risk of allergenicity. In the present study, we examined variations in the actinidin level in Actinidia varieties. Among several varieties having trace amounts of actinidin, A. chinensis ‘Kohi’ was targeted to be analyzed for the molecular basis for the phenotype. ‘Kohi’ had below the detectable transcript level of Act1a, a critical gene for actinidin level. The upstream region of Act1a in ‘Kohi’ constituted different sequences from that of A. deliciosa ‘Hayward’, which has an active promoter for high expression of Act1a. The ‘Kohi’ sequence in the diverged region (upstream from −873 b) was rich in cytosine residues methylated at a higher level than in ‘Hayward’. Our data suggest the possibility of novel epigenetic regulation to reduce the actinidin level. The molecular mechanism for the phenotype in ‘Kohi’ was differentiated from ‘Hort16A’, a globally popular cultivar with a low level of actinidin. This cultivar could be a choice as a genetic resource in breeding to develop cultivars with controlled actinidin levels.

著者

Yusuke Kamiyoshihara Shinji Mizuno Mirai Azuma Fumika Miyohashi Makoto Yoshida Junko Matsuno Sho Takahashi Shin Abe Hajime Shiba Keiichi Watanabe Hiroaki Inoue Akira Tateishi

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.OKD-142, (Released:2018-01-26)

被引用文献数

1

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Avocado fruit ripen with ethylene production after harvest and the flesh becomes soft and edible due to degradation of cell wall polysaccharides during ripening. α-l-Arabinofuranosidase is a hydrolytic enzyme known to digest arabinose-containing cell wall polysaccharides. It has been shown that its activity increased with fruit ripening. However, our previous study showed that an α-l-arabinofuranosidase gene (PaArf/Xyl3A) is expressed in the avocado fruit before ethylene production. In addition, the transcripts were detected in some organs in which the level of ethylene was extremely low. These results indicate that the gene expression is independent of ethylene. In the present study, we carried out immunoblot analyses of α-l-arabinofuranosidase at the protein level. Using a polyclonal antibody raised against Japanese pear α-l-arabinofuranosidase, two α-l-arabinofuranosidase proteins with molecular masses of 72 kDa and 68 kDa, presumably belonging to glycoside hydrolase family 3, were detected in ripening avocado fruit. The protein levels in ethylene or 1-methylcyclopropene (1-MCP)-treated fruits were examined and the results indicated that the two proteins responded to ethylene in opposite ways; the 68 kDa protein showed a temporary accumulation, whereas the 72 kDa protein exhibited dissipation possibly caused by a loss of stability. The total enzyme activity of α-l-arabinofuranosidase was elevated faster in the ethylene-treated fruit throughout ripening and was slower in the 1-MCP-treated fruit, suggesting the existence of another α-l-arabinofuranosidase, which did not cross-react with the antibody and was positively regulated by ethylene, in ripening avocado fruit.