著者

Nobuyuki Sasaki Masato Yamatoku Tomoya Tsuchida Hiroyuki Sato Keiichiro Yamaguchi

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.8, pp.20230004, 2023 (Released:2023-02-28)

参考文献数

32

被引用文献数

3

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Objectives: There is no established treatment for chronic fatigue and various cognitive dysfunctions (brain fog) caused by long coronavirus disease 2019 (COVID-19). We aimed to clarify the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for treating these symptoms.Methods: High-frequency rTMS was applied to occipital and frontal lobes in 12 patients with chronic fatigue and cognitive dysfunction 3 months after severe acute respiratory syndrome coronavirus 2 infection. Before and after ten sessions of rTMS, Brief Fatigue Inventory (BFI), Apathy Scale (AS), and Wechsler Adult Intelligence Scale-fourth edition (WAIS4) were determined and N-isopropyl-p-[123I]iodoamphetamine single photon emission computed tomography (SPECT) was performed.Results: Twelve subjects completed ten sessions of rTMS without adverse events. The mean age of the subjects was 44.3 ± 10.7 years, and the mean duration of illness was 202.4 ± 114.5 days. BFI, which was 5.7 ± 2.3 before the intervention, decreased significantly to 1.9 ± 1.8 after the intervention. The AS was significantly decreased after the intervention from 19.2 ± 8.7 to 10.3 ± 7.2. All WAIS4 sub-items were significantly improved after rTMS intervention, and the full-scale intelligence quotient increased from 94.6 ± 10.9 to 104.4 ± 13.0. Hypoperfusion in the bilateral occipital and frontal lobes observed on SPECT improved in extent and severity after ten sessions of rTMS.Conclusions: Although we are still in the early stages of exploring the effects of rTMS, the procedure has the potential for use as a new non-invasive treatment for the symptoms of long COVID.

著者

Ayako Saito Yoichi Takeuchi Saeko Kagaya Yoshie Ojima Hirotaka Fukami Hiroyuki Sato Ken Matsuda Tasuku Nagasawa

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.242, no.1, pp.53-62, 2017 (Released:2017-05-24)

参考文献数

36

被引用文献数

7

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Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is systemic vascular inflammation. Microscopic polyangiitis (MPA) is a major type of AAV in Japan. MPA often affects the kidneys and lungs, leading to death if untreated. Induction therapy (i.e., initial treatment) for MPA has not been optimized, although methylprednisolone and cyclophosphamide are commonly used. Recently, rituximab (RTX) (a monoclonal antibody against the protein CD20) has also been used to treat refractory AAV. RTX at 375 mg/m2/week for 4 weeks (i.e., the conventional lymphoma dosing schedule) is used, but the optimal dosing schedule is controversial. Indeed, a single-dose of RTX successfully controlled nephrotic syndrome. However, to date, the effectiveness of a single RTX dose in treating MPA has not been fully investigated in Japan. This was a retrospective observational study. Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2). We investigated the patients’ clinical features, as well as the efficacy and safety of RTX treatment. All patients attained remission on a tapered prednisolone dose of < 10 mg/day during the first 12 months. One patient relapsed after 12 months whereas another required hospitalization owing to infective spondyloarthritis. Adverse reactions to RTX infusion and late-onset neutropenia were not observed. Therefore, a single-dose treatment with RTX induced remission with few complications, and allowed tapering the prednisolone treatment. We conclude that a single dose of RTX is a promising induction therapy for MPA, reducing the cost associated with multiple doses.

著者

Hiroyuki Sato

出版者

The Japan Society for Industrial and Applied Mathematics

雑誌

JSIAM Letters (ISSN:18830609)

巻号頁・発行日

vol.7, pp.13-16, 2015 (Released:2015-01-25)

参考文献数

8

被引用文献数

1 7

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The joint singular value decomposition of multiple rectangular matrices is formulated as a Riemannian optimization problem on the product of two Stiefel manifolds. In this paper, the geometry of the objective function and the Riemannian manifold for this problem are studied to develop a Riemannian trust-region algorithm. The proposed algorithm globally and locally quadratically converges, and our numerical experiments demonstrate that it performs much better than the steepest descent method.

著者

Angeline Ping Ping TEH Watanyoo PRATAKPIRIYA Yuichi HIDAKA Hiroyuki SATO Takuya HIRAI Ryoji YAMAGUCHI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.4, pp.714-718, 2017 (Released:2017-04-05)

参考文献数

17

被引用文献数

4

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A 3.5-year-old female Chihuahua was presented with complaint of neck pain, intermittent cough and dysphagia. Physical examination and diagnostic imaging of neck region revealed a solid and highly vascularized mass involving the retropharyngeal region. Histologically, the mass showed an atypical zellballen pattern which comprised of high density of type I chief cells with high nuclear cytoplasmic ratio and separated by delicate fibrovascular stroma. Immunoreactivity for neuroendocrine markers was diffusely positive in cytoplasm of tumor cells. Disseminated tumor emboli in external jugular vein were detected 6 months after initial surgery. An electron microscopic study revealed numerous electron-dense intracytoplasmic neurosecretory granules. Based on these findings, carotid body carcinoma was diagnosed.

著者

Angeline Ping Ping TEH Watanyoo PRATAKPIRIYA Yuichi HIDAKA Hiroyuki SATO Takuya HIRAI Ryoji YAMAGUCHI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0501, (Released:2017-02-27)

被引用文献数

4

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A 3.5-year-old female Chihuahua was presented with complaint of neck pain, intermittent cough and dysphagia. Physical examination and diagnostic imaging of neck region revealed a solid and highly vascularized mass involving the retropharyngeal region. Histologically, the mass showed an atypical zellballen pattern which comprised of high density of type I chief cells with high nuclear cytoplasmic ratio and separated by delicate fibrovascular stroma. Immunoreactivity for neuroendocrine markers was diffusely positive in cytoplasm of tumor cells. Disseminated tumor emboli in external jugular vein were detected 6 months after initial surgery. An electron microscopic study revealed numerous electron-dense intracytoplasmic neurosecretory granules. Based on these findings, carotid body carcinoma was diagnosed.

著者

Minoru Nishimura Makoto Kusaba Kenzo Miyahara Takeshi Nishio Shuichi Iida Tokio Imbe Hiroyuki Sato

出版者

日本育種学会

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

vol.55, no.1, pp.103-105, 2005 (Released:2005-03-15)

参考文献数

7

被引用文献数

15 26

著者

HIROYUKI SATO HIDETOSHI OTA

出版者

日本爬虫両棲類学会

雑誌

Current Herpetology (ISSN:13455834)

巻号頁・発行日

vol.20, no.1, pp.19-25, 2001 (Released:2009-03-27)

参考文献数

16

被引用文献数

7

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The male and female karyotypes were examined for 10 specimens of the Chinese soft-shelled turtle, Pelodiscus sinensis, from the main islands of Japan and Taiwan by the bone marrow air-dry technique. One specimen of Dogania subplana was also examined karyologically. Although both P. sinensis and D. subplana had 2n=66 chromosomes, they showed an interspecific variation in chromosome morphology. No karyotypical differences were evident between the Japanese and Taiwanese samples of P. sinensis, or within either of them. Comparisons of the present results with previously reported trionychine karyotypes indicate that there are some interspecific and intraspecific variations in centromeric positions of several macrochromosome pairs in this subfamily.