- 著者
-
Yasuaki Takeji
Tomohiko Taniguchi
Takeshi Morimoto
Shinichi Shirai
Takeshi Kitai
Hiroyuki Tabata
Kazuki Kitano
Nobuhisa Ono
Ryosuke Murai
Kohei Osakada
Koichiro Murata
Masanao Nakai
Hiroshi Tsuneyoshi
Tomohisa Tada
Masashi Amano
Hiroki Shiomi
Hirotoshi Watanabe
Yusuke Yoshikawa
Ko Yamamoto
Mamoru Toyofuku
Shojiro Tatsushima
Norino Kanamori
Makoto Miyake
Hiroyuki Nakayama
Kazuya Nagao
Masayasu Izuhara
Kenji Nakatsuma
Moriaki Inoko
Takanari Fujita
Masahiro Kimura
Mitsuru Ishii
Shunsuke Usami
Kenichiro Sawada
Fumiko Nakazeki
Marie Okabayashi
Manabu Shirotani
Yasutaka Inuzuka
Tatsuhiko Komiya
Kenji Minatoya
Takeshi Kimura
on behalf of the CURRENT AS Registry-2 Investigators
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-21-1062, (Released:2022-04-19)
- 参考文献数
- 29
- 被引用文献数
-
2
Background: There is scarce data evaluating the current practice pattern and clinical outcomes for patients with severe aortic stenosis (AS), including both those who underwent surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) and those who were managed conservatively in the TAVI era.Methods and Results: The Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis (CURRENT AS) Registry-2 is a prospective, physician-initiated, multicenter registry enrolling consecutive patients who were diagnosed with severe AS between April 2018 and December 2020 among 21 centers in Japan. The rationale for the prospective enrollment was to standardize the assessment of symptomatic status, echocardiographic evaluation, and other recommended diagnostic examinations such as computed tomography and measurement of B-type natriuretic peptide. Moreover, the schedule of clinical and echocardiographic follow up was prospectively defined and strongly recommended for patients who were managed conservatively. The entire study population consisted of 3,394 patients (mean age: 81.6 years and women: 60%). Etiology of AS was degenerative in 90% of patients. AS-related symptoms were present in 60% of patients; these were most often heart failure symptoms. The prevalence of high- and low-gradient AS was 58% and 42%, respectively, with classical and paradoxical low-flow low-gradient AS in 4.5% and 6.7%, respectively.Conclusions: The CURRENT AS Registry-2 might be large and meticulous enough to determine the appropriate timing of intervention for patients with severe AS in contemporary clinical practice.