- 著者
- Xiaomin Sun Zhen-Bo Cao Kumpei Tanisawa Tomoko Ito Satomi Oshima Yoshiko Ishimi Izumi Tabata Mitsuru Higuchi
- 出版者
- Japan Atherosclerosis Society
- 雑誌
- Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
- 巻号頁・発行日
- vol.22, no.4, pp.355-362, 2015-04-21 (Released:2015-04-21)
- 参考文献数
- 35
- 被引用文献数
- 24 26
Aim: Low circulating 25-hydroxyvitamin D [25(OH)D] concentration has been linked to a high prevalence of cardiovascular disease. One explanation for this phenomenon is that there is an association between the serum 25(OH)D level and lipid profiles. However, studies examining this relationship are limited and have yielded inconsistent results. We thus aimed to evaluate the association between the serum 25(OH)D concentration and lipid profiles in Japanese men taking into consideration confounding factors, including the visceral fat area (VFA) and cardiorespiratory fitness.Methods: A total of 136 men (age range: 20-79 years) participated in our study. Fasting blood samples were analyzed to determine the 25(OH)D, oxidized low-density lipoprotein (oxLDL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), apolipoprotein (Apo)A-1 and ApoB levels. The VFA was evaluated on magnetic resonance imaging (MRI), and cardiorespiratory fitness was assessed by measuring the peak oxygen uptake (O2 peak).Results: The median 25(OH)D concentration was 35.6 nmol/L, and the prevalence of 25(OH)D deficiency was 78.7%. A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness.Conclusions: Serum 25(OH)D level is inversely correlated with the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values in Japanese men, independent of the VFA and cardiorespiratory fitness.
- 著者
- Jun Hamano Takayuki Shimizu Katsunori Tsuji Wendy M Kohrt Izumi Tabata
- 出版者
- The Japanese Society of Physical Fitness and Sports Medicine
- 雑誌
- The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
- 巻号頁・発行日
- vol.10, no.3, pp.129-137, 2021-05-25 (Released:2021-05-13)
- 参考文献数
- 39
- 被引用文献数
- 1 6
Increased serum parathyroid hormone (PTH) during moderate-intensity exercise has been reported, suggesting that such exercise may stimulate bone resorption. This study was undertaken to observe the effects of exhausting high-intensity intermittent exercise (HIIE) on serum PTH and on blood parameters that may affect PTH secretion during exercise. Seven young trained adults exercised on 2 days after overnight fasting. On the HIIE day, they performed 6–7 exhausting bouts of 20-sec bicycle exercise (intensity, 170% VO2max) with intervening 10-sec rests. On the moderate-intensity exercise (MIE) day, the subjects biked for 60 min at 70% VO2max. The peak lactate concentration in blood after the HIIE was 15.2 ± 1.3 mmol/l. The blood lactate concentration at the end of the MIE was 2.2 ± 0.9 mmol/l. The HIIE significantly reduced the serum PTH (Pre: 30 ± 5 pg/ml, 10 min post-HIIE: 22 ± 4 pg/ml, p < 0.05), whereas the MIE significantly elevated the serum PTH. The HIIE induced a significant increase in serum ionized Ca (iCa); but MIE did not affect iCa. The serum cortisol concentration post-MIE was significantly higher than that observed pre-exercise; no changes from the pre-exercise value were noted post-HIIE. The serum phosphate concentration immediately post-HIIE increased significantly to the same level as that post-MIE. No changes in serum C-terminal telopeptide of Type I collagen (a marker of bone resorption) was observed after the HIIE or MIE. Although these results do not identify stimulator(s) for PTH secretion during HIIE and MIE, they indicate that HIIE does not induce an exercise-induced increase in PTH (which might deteriorate bone metabolism).
- 著者
- Kazuhiko Higashida Izumi Tabata Mitsuru Higuchi Shin Terada
- 出版者
- 一般社団法人日本体力医学会
- 雑誌
- The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
- 巻号頁・発行日
- vol.2, no.3, pp.355-360, 2013-08-25 (Released:2013-09-08)
- 参考文献数
- 42
- 被引用文献数
- 1 1
Skeletal muscle is the primary site of glucose uptake in humans. Glucose transport activity, which is the rate-limiting step in muscle glucose metabolism, is linearly related to the content of the GLUT-4 isoform of the glucose transporter. Therefore, the level of GLUT-4 in skeletal muscle may be an important determinant of whole-body glucose disposal. It has been well documented that long-term, low- to moderate-intensity endurance exercise training induces an increase in muscle GLUT-4 content. However, emerging evidence suggests that an adaptive increase in GLUT-4 occurs even after a single acute bout of exercise or high-intensity intermittent exercise training. Recent findings also indicate that nutritional status affects GLUT-4 expression in skeletal muscle. This review provides an overview of the effects of exercise and nutritional status on GLUT-4 content in skeletal muscle, and summarizes recent progress in elucidating the molecular regulation of muscle GLUT-4 gene expression by exercise and nutritional stimuli.