著者

Jun Komiyama Masao Iwagami Takahiro Mori Naoaki Kuroda Xueying Jin Tomoko Ito Nanako Tamiya

出版者

Society for Clinical Epidemiology

雑誌

Annals of Clinical Epidemiology (ISSN:24344338)

巻号頁・発行日

vol.4, no.1, pp.11-19, 2022 (Released:2022-01-07)

参考文献数

36

被引用文献数

1

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BACKGROUNDAlthough outpatient cardiac rehabilitation has been shown to be effective, the participation status of older cardiac patients is unclear in real-world settings. We investigated the proportion and associated factors of outpatient cardiac rehabilitation participation among older patients with heart diseases after cardiac intervention.METHODSWe analyzed data from medical and long-term care insurance claims data from two municipalities in Japan. The data coverage period was between April 2014 and March 2019 in City A and between April 2012 and November 2016 in City B. We identified patients aged ≥65 years with post-operative acute myocardial infarction, angina pectoris, or heart valve disease. We estimated the proportion of cardiac rehabilitation participation and conducted logistic regression to identify factors (age, sex, type of cardiac disease, open-heart surgery, Charlson comorbidity index, long-term care need level, catecholamine use, inpatient cardiac rehabilitation, and hospital volume for cardiac rehabilitation) associated with outpatient cardiac rehabilitation participation.RESULTSA total of 690 patients were included in this study. The proportion of patients receiving outpatient cardiac rehabilitation was 9.0% overall. Multivariable logistic regression analysis suggested that men (adjusted OR 3.98; 95% CI 1.69–9.37), acute myocardial infarction (adjusted OR 2.76; 95% CI 1.20–6.36; reference angina pectoris), inpatient cardiac rehabilitation (adjusted OR 17.01; 95% CI 5.33–54.24), and “hospital volume” for cardiac rehabilitation (adjusted OR 4.35; 95% CI 1.14–16.57 for high-volume hospitals; reference low-volume hospital) were independently associated with outpatient cardiac rehabilitation.CONCLUSIONSThe participation rate of outpatient cardiac rehabilitation among older post-operative cardiac patients was suboptimal. Further studies are warranted to examine its generalizability and whether a targeted approach to a group of patients who are less likely to receive outpatient cardiac rehabilitation could improve the participation rate.

著者

伊藤 智子 加藤 真紀 梶谷 みゆき 常松 さゆり 諸井 望 金築 真志 Tomoko ITO Maki KATO Miyuki KAJITANI Sayuri TSUNEMATSU Nozomu MOROI Masashi KANETSUKI

出版者

島根県立大学短期大学部出雲キャンパス

雑誌

島根県立大学短期大学部出雲キャンパス研究紀要 (ISSN:18824382)

巻号頁・発行日

vol.2, pp.23-34, 2008

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2007年本紀要第1巻にて標記の第1報を報告した(伊藤、2007)。2008年は、特養で生活する高齢者のエンパワメントには、ケアスタッフの意識・行動が大きく関わつていると考え、前年度調査対象とした高齢者を担当するケアスタッフにケア意識に関する半構成的面接を行い、この2年間の調査結果を合わせて再度検討を行った。その結果、 1)特養入居受け入れ支援 2)生活の継続性を重視する意志の尊重 3)視聴覚機能を補うケア 4)家族とのほどよい距離感を感じるケア 5)馴染みの人との関係維持と新たな人間関係づくり支援 6)日常生活の中での役割づくり 7)落ち着く居場所づくり 8)看護職による疾病の管理の8点が明らかとなった。

著者

伊藤 智子 加藤 真紀 梶谷 みゆき 常松 さゆり 諸井 望 金築 真志 Tomoko ITO Maki KATO Miyuki KAJITANI Sayuri TSUNEMATSU Nozomu MOROI Masashi KANETSUKI

出版者

島根県立大学短期大学部出雲キャンパス

雑誌

島根県立大学短期大学部出雲キャンパス研究紀要 (ISSN:18824382)

巻号頁・発行日

vol.1, pp.51-58, 2007

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生活の場が変化することでエンパワメントの維持が困難になりやすいと考えられている特別養護老人ホームで生活をする高齢者の施設入居前後の社会関連性の変化を把握した。そして、その変化の理由を本人へのインタビュー、家族への質問紙調査、施設内既存資料で得られた結果から事例検討により分析した。その結果、特養で生活する高齢者のエンパワメント支援として1.本人の施設入居受け入れ支援2.特養生活の中で役割を創る3.家族とのほどよい距離感を感じる支援4.本人の落ち着く居場所づくり5.視聴覚機能を補う支援の5点が明らかとなった。今後、事例別の結果を現在のケア内容と照らし合わせ、エンパワメントを支援するケアの改善が必要である。

著者

Takahiro USHIGUSA Yoshiyuki KOYAMA Tomoko ITO Kenichi WATANABE James K. CHAMBERS Aya HASEGAWA Kazuyuki UCHIDA Ryoji KANEGI Shingo HATOYA Toshio INABA Kikuya SUGIURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0466, (Released:2018-01-01)

被引用文献数

6

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By using a complex of DNA, polyethylenimine and chondroitin sulfate, the in vivo transfection of early secretory antigenic target-6 (ESAT-6) gene into tumor cells was found to cause significant suppression of the tumor growth. In order to apply the method in clinical cancer treatment in dogs and cats, mechanisms underlying the suppressive effects were investigated in a tumor-bearing mouse model. The transfection efficiency was only about 10%, but the transfection of ESAT-6 DNA nevertheless induced systemic immune responses against ESAT-6. By triple injection of ESAT-6 DNA at three day intervals, the tumor was significantly reduced and almost disappeared by 5 days after the start of treatment, and did not increase for more than 15 days after the final treatment. In the immunohistochemistry, a larger number of dendritic cells (DCs)/macrophages expressing ionized calcium-binding adapter molecule 1 and CD3+ T cells was observed in tumors treated with ESAT-6 DNA, and their population further increased significantly by day 5. Moreover, the amount of tumor necrosis factor, which is an apoptosis-inducing factor produced mainly by DCs/macrophages, was greater in the ESAT-6 DNA treated tumors than in controls, and increased with repeat of the treatment. These results indicate that in vivo transfection of ESAT-6 DNA into tumor cells elicits significant inhibition of tumor growth, by inducing potent activity of innate immunity mediated by DCs/macrophages, which may be followed by adaptive immunity against tumor associated antigens, which was elicited by the costimulation with ESAT-6 antigen.

著者

Xiaomin Sun Zhen-Bo Cao Kumpei Tanisawa Tomoko Ito Satomi Oshima Yoshiko Ishimi Izumi Tabata Mitsuru Higuchi

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.22, no.4, pp.355-362, 2015-04-21 (Released:2015-04-21)

参考文献数

35

被引用文献数

24 26

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Aim: Low circulating 25-hydroxyvitamin D [25(OH)D] concentration has been linked to a high prevalence of cardiovascular disease. One explanation for this phenomenon is that there is an association between the serum 25(OH)D level and lipid profiles. However, studies examining this relationship are limited and have yielded inconsistent results. We thus aimed to evaluate the association between the serum 25(OH)D concentration and lipid profiles in Japanese men taking into consideration confounding factors, including the visceral fat area (VFA) and cardiorespiratory fitness.Methods: A total of 136 men (age range: 20-79 years) participated in our study. Fasting blood samples were analyzed to determine the 25(OH)D, oxidized low-density lipoprotein (oxLDL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), apolipoprotein (Apo)A-1 and ApoB levels. The VFA was evaluated on magnetic resonance imaging (MRI), and cardiorespiratory fitness was assessed by measuring the peak oxygen uptake (O2 peak).Results: The median 25(OH)D concentration was 35.6 nmol/L, and the prevalence of 25(OH)D deficiency was 78.7%. A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness.Conclusions: Serum 25(OH)D level is inversely correlated with the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values in Japanese men, independent of the VFA and cardiorespiratory fitness.

著者

伊藤 智子 加藤 真紀 佐藤 公子 山下 一也 Tomoko ITO Maki KATO Kimiko SATO Kazuya YAMASHITA

出版者

島根県立大学出雲キャンパス

雑誌

島根県立大学出雲キャンパス紀要 = Bulletin of the University of Shimane Izumo Campus (ISSN:2187199X)

巻号頁・発行日

vol.12, pp.11-17, 2017

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【目的】認知症予防としての、脳トレの効果を検討するため、七田式いきいき脳開発プログラムの効果検証を試みた。【方法】65-90歳の健常高齢者70名を七田式脳トレ群、対照群の2群に分け、6ヶ月間実施した。介入前後に、MMSE、HDS-R、FAB、CADi、やる気指数、うつ指標の測定を行った。群別に各調査項目、介入前後の差を解析した。また介入前後の認知機能検査値とSDS、やる気指数の相関を解析した。【結果】脳トレ群の介入前後のFAB 得点において有意差が見られた。脳トレ群においてFAB とHDS-R 値がSDS 指数と正の相関があった。【考察】6ヶ月の七田式脳トレ継続による、前頭葉機能の活性化が示唆された。

著者

祝原 あゆみ 井上 千晶 山下 一也 齋藤 茂子 伊藤 智子 松本 亥智江 加藤 真紀 松岡 文子 持田 和夫 福間 紀子 錦織 圭佑 Ayumi IWAIBARA Chiaki INOUE Kazuya YAMASHITA Shigeko SAITO Tomoko ITO Ichie MATSUMOTO Maki KATO Ayako MATSUOKA Kazuo MOCHIDA Noriko FUKUMA Keisuke NISHIKORI

出版者

島根県立大学短期大学部出雲キャンパス

雑誌

島根県立大学短期大学部出雲キャンパス研究紀要 (ISSN:18824382)

巻号頁・発行日

vol.5, pp.65-75, 2011

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S県A市とS県立大学が取り組む共同事業に参加した地区スタッフが事業から得ているものを分析し,今後の支援について検討することを目的に自記式質問紙調査を行った。その結果「プログラム内容の満足感」は高いが「教室運営の満足感」は低いことや,【高齢者への認識の変化】【自らが感じたプラスの効果】【介護予防への関心の高まり】【活動継続に対する意欲】の4カテゴリーの抽出から,個人のエンパワメント効果が明らかになった。1年間の事業は住民が介護予防に取り組むきっかけとしての役割を果たしており、今後も住民のパートナーとしての継続した関わりが必要と考えられた。

著者

Yuichi Katayose Hiroyuki Kanamori Michihiko Shimomura Hajime Ohyanagi Hiroshi Ikawa Hiroshi Minami Michie Shibata Tomoko Ito Kanako Kurita Kazue Ito Yasutaka Tsubokura Akito Kaga Jianzhong Wu Takashi Matsumoto Kyuya Harada Takuji Sasaki

出版者

Japanese Society of Breeding

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

vol.61, no.5, pp.661-664, 2012 (Released:2012-02-04)

参考文献数

10

被引用文献数

11 13 3

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Soybean [Glycine max (L) Merrill] is one of the most important leguminous crops and ranks fourth after to rice, wheat and maize in terms of world crop production. Soybean contains abundant protein and oil, which makes it a major source of nutritious food, livestock feed and industrial products. In Japan, soybean is also an important source of traditional staples such as tofu, natto, miso and soy sauce. The soybean genome was determined in 2010. With its enormous size, physical mapping and genome sequencing are the most effective approaches towards understanding the structure and function of the soybean genome. We constructed bacterial artificial chromosome (BAC) libraries from the Japanese soybean cultivar, Enrei. The end-sequences of approximately 100,000 BAC clones were analyzed and used for construction of a BAC-based physical map of the genome. BLAST analysis between Enrei BAC-end sequences and the Williams82 genome was carried out to increase the saturation of the map. This physical map will be used to characterize the genome structure of Japanese soybean cultivars, to develop methods for the isolation of agronomically important genes and to facilitate comparative soybean genome research. The current status of physical mapping of the soybean genome and construction of database are presented.