著者

ShiWei Yuan Lei Li Ji Yang Yuanhang He WanTing Zhou Jin Li

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Electronics Express (ISSN:13492543)

巻号頁・発行日

pp.18.20210098, (Released:2021-04-20)

参考文献数

30

被引用文献数

3

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Hardware trojans(HT) is one of the main threats for hardware security, especially attacks on General-Purpose Registers(GPRs) of processors. This paper presented a novel method to detect HT induced attacks by comparing the states of GPRs with an embedded reference model in real time. Firstly, the instruction sequence was realigned with four principles. Secondly, based on the realigned instruction stream, a reference model for GPRs was built. Finally, HT induced attacks on GPRs can be detected by comparing the expected GPRs’ state from the reference model with the sampled GPRs’ state from processors. We integrated this method into a RISC-V core of PULpino and investigated the feasibility with different programs. The experimental results showed that all the randomly inserted HT attacks can be detected in real time with the latency of two clock cycles.

著者

青山 郁子 Michelle F. Wright Shanmukh V. Kamble Zheng Li Shruti Soudi Lei Li Shu Chang

出版者

一般社団法人 日本教育心理学会

雑誌

日本教育心理学会総会発表論文集 第57回総会発表論文集 (ISSN:21895538)

巻号頁・発行日

pp.501, 2015-08-19 (Released:2017-03-30)

著者

Lin Wu Ya-Nan Yao Zi-Cheng Yuan Dandan Di Lei Li Bin Hu

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

pp.19P288, (Released:2019-10-25)

被引用文献数

7

著者

Wei He Li-Fang Fan Qing Du Bai Xiang Chun-Lei Li Min Bai Yong-Zhen Chang De-Ying Cao

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.57, no.2, pp.122-128, 2009-02-01 (Released:2009-02-01)

参考文献数

31

被引用文献数

7 17 9

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The purpose of the study is to perform the in vitro and in vivo evaluation of multi-layer film coatings for omeprazole. The system consists of drug-layered or drug-containing core pellets coated with salt (sodium chloride and disodium hydrogen phosphate), hydroxypropyl methyl cellulose (HPMC), and enteric film-coating layer, respectively. The drug-layered core pellets were prepared by a coating layer of omeprazole on inert pellet cores in fluidized bed coater. An in vitro/in vivo gastro-resistance study was conducted, and a dissolution study was performed in pH 7.4 phosphate buffer for omeprazole release. The multi-layer coated pellets were stable in gastric pH conditions and upper gastrointestinal (GI) tract in rats. Salt layer improved the drug stability, and its coating levels had little influence on the dissolution profiles of omeprazole. The rate of drug release was significantly delayed by HPMC layer. The salt layer could function as a separated layer, and substitute part of the HPMC layer and decrease the coating levels of HPMC. The bioavailability (AUC) of the multi-layer coated drug-layered and drug-containing pellets was 3.48±0.86 and 2.97±0.57 μg·h/ml, respectively. The drug-layered pellets with multi-layer film coatings not only provided delayed and rapid release of omeprazole, but also could provide a good stable property for omeprazole. It was confirmed that rapid in vitro drug release rate resulted in better absorption.