著者

Yan Nie Lijuan Li Yanli Tang Bin Wang

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.15, pp.211-215, 2019 (Released:2019-10-29)

参考文献数

31

被引用文献数

11

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External forcings among the different phases of the Coupled Model Intercomparison Project (CMIP) vary considerably, but their impacts have not been extensively investigated yet. This study compares the impacts of CMIP5 and CMIP6 forcings on model stability and the 20th-century global warming and El-Niño Southern Oscillation (ENSO) based on the Pre-Industrial control (PI-control) and historical runs of the Flexible Global Ocean–Atmosphere–Land System Model: Grid-point Version 2 (FGOALS-g2). Results indicate that CMIP6 forcings result in a larger climate drift and a lower climatological global average surface temperature (GAST) than those of CMIP5 in PI-control runs. In historical runs, stronger 20th-century warming trends occur during the periods 1910-1940 and 1970-2005 using CMIP6 forcings, which are closer to the HadCRUT than those of the CMIP5 forcings simulation. A stronger spurious warming trend in the CMIP6 results in an evolution of GAST that is less consistent with the HadCRUT dataset than that in the CMIP5 during 1940-1970. Among all forcings, GHGs and aerosol forcings play the dominant roles in differences in GAST, particularly in the Northern Hemisphere. In both the PI-control and historical runs, a larger ENSO amplitude and smaller seasonality are simulated in CMIP6 than in CMIP5.

著者

Yan Nie Lijuan Li Yanli Tang Bin Wang

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2019-038, (Released:2019-09-23)

被引用文献数

11

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External forcings among the different phases of the Coupled Model Intercomparison Project (CMIP) vary considerably, but their impacts have not been extensively investigated yet. This study compares the impacts of CMIP5 and CMIP6 forcings on model stability and the 20th-century global warming and El-Niño Southern Oscillation (ENSO) based on the Pre-Industrial control (PI-control) and historical runs of the Flexible Global Ocean–Atmosphere–Land System Model: Grid-point Version 2 (FGOALS-g2). Results indicate that CMIP6 forcings result in a larger climate drift and a lower climatological global average surface temperature (GAST) than those of CMIP5 in PI-control runs. In historical runs, stronger 20th-century warming trends occur during the periods 1910-1940 and 1970-2005 using CMIP6 forcings, which are closer to the HadCRUT than those of the CMIP5 forcings simulation. A stronger spurious warming trend in the CMIP6 results in an evolution of GAST that is less consistent with the HadCRUT dataset than that in the CMIP5 during 1940-1970. Among all forcings, GHGs and aerosol forcings play the dominant roles in differences in GAST, particularly in the Northern Hemisphere. In both the PI-control and historical runs, a larger ENSO amplitude and smaller seasonality are simulated in CMIP6 than in CMIP5.

著者

Siwei Zhang Jing Zhou Lijuan Li Xinyao Pan Jing Lin Chuyu Li Wing Ting Leung Ling Wang

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2021.01320, (Released:2021-11-10)

参考文献数

122

被引用文献数

4

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In China, cardiovascular disease (CVD) has surpassed malignant tumours to become the disease with the highest mortality rate, and atherosclerosis (AS) is an important pathological cause of CVD. Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone in circulating human blood and is a precursor of estrogen and androgen. DHEA is converted into a series of sex hormones in local peripheral tissues where its acts physiologically. DHEA also acts therapeutically, thereby avoiding the adverse systemic reactions to sex hormones. DHEA inhibits AS, thus inhibiting the development of CVD, and it improves the prognosis for CVD. The incidence of CVD in postmenopausal women is substantially higher than that in premenopausal women, and that incidence is believed to be related to a decrease in ovarian function. The current review analyzes the mechanisms of postmenopausal women's susceptibility to AS. They tend to have dyslipidemia, and their vascular smooth muscle cells (VSMCs) proliferate and migrate more. In addition, oxidative stress and the inflammatory response of endothelial cells (ECs) are more serious in postmenopausal women. This review also discusses how DHEA combats AS by countering these mechanisms, which include regulating the blood lipid status, protecting ECs (including coping with oxidative stress and inflammatory reactions of the vascular endothelium, inhibiting apoptosis of ECs, and inducing NO production) and inhibiting the proliferation and migration of VSMCs. As a result, DHEA has great value in preventing AS and inhibiting its progression in postmenopausal women.