著者

Lin Chen Lu Wang Tim Li De-Zheng Sun

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.14, pp.126-131, 2018 (Released:2018-09-12)

参考文献数

55

被引用文献数

11

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The study presents the contrasting characteristics of cloud-radiative feedbacks to the cold tongue (CT) and warm pool (WP) El Niño (EN). The maximum sea surface temperature anomalies (SSTA) of the CT-EN are located in the far-eastern Pacific. However, the maximum responses of the shortwave- and longwave- cloud-radiative forcing (SWCRF and LWCRF) to the CT-EN warming are centered near the dateline, showing 70° westward shift relative to the maximum SSTA center of CT-WN. In contrast, the maximum responses of the SWCRF and LWCRF to the WP-EN warming show only slight westward shift relative to the maximum SSTA center. The contrasting cloud-radiative feedbacks to the two types of ENs can be traced back to the contrasting precipitation feedbacks, which is associated with the convection threshold. When the warm SSTA of CT-EN occurs in the relatively cold eastern Pacific, the total SST in-situ may not exceed the convection threshold. Therefore, the induced precipitation anomaly would occur towards the warm western Pacific, and the corresponding cloud cover and cloud-radiative feedbacks would exhibit an apparent westward shift. As the warm SSTA of WP-EN occurs in the relatively warm central Pacific, the corresponding responses of the anomalous fields to the WP-EN show only slight westward displacement.

著者

Hsiao-Fan YEH Ruey-Lin CHEN

出版者

Japan Association for Philosophy of Science

雑誌

Annals of the Japan Association for Philosophy of Science (ISSN:04530691)

巻号頁・発行日

vol.26, pp.39-60, 2017 (Released:2017-11-07)

参考文献数

29

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This paper proposes an experiment-based methodology for both classical genetics and molecular biology by integrating Lindley Darden's mechanism-centered approach and C. Kenneth Waters' phenomenon-centered approach. We argue that the methodology based on experiments offers a satisfactory account of the development of the two biological disciplines. The methodology considers discovery of new mechanisms, investigation of new phenomena, and construction of new theories together, in which experiments play a central role. Experimentation connects the three type of conduct, which work as both ends and means, occurring in a circular way and constituting an overall process of scientific practice from classical genetics to molecular biology.

著者

Hui Liu Yixin Shi Jia Zhan Yingchun Liu Jing Zhou Biao Su Yue Chen Ling Wang Lin Chen

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

vol.17, no.1, pp.26-36, 2023-02-28 (Released:2023-03-11)

参考文献数

50

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Cervical lymph node metastasis (CLNM) of papillary thyroid carcinoma (PTC) is directly associated with clinical management and prognosis. In this study, we aimed to evaluate the value of conventional ultrasound (US) combined with ENST00000438158 in predicting CLNM of PTC. Fourty-nine PTC patients underwent US examination and US-guided fine needle aspiration (FNA). ENST00000438158 expression in FNA cytological specimens and PTC cell lines was detected using real-time reverse transcription polymerase chain reaction (qRT-PCR). The role of ENST00000438158 expression in the proliferation, migration, invasion, apoptosis, and cell cycle of PTC cells was investigated by Cell Counting Kit-8 (CCK8) and clone formation experiments, transwell assay, and flow cytometry, respectively. Calcification, capsule contact, and low ENST00000438158 expression were independently associated with PTC with CLNM (all p < 0.05). The combination of multiple US features was more valuable than a single US feature in predicting CLNM in PTC. Adding ENST0000438158 to US greatly improved the value of differentiation of PTC with or without CLNM. In conclusion, ENST00000438158 is a potential molecular marker for predicting CLNM in PTC. ENST00000438158 combined with US features is highly valuable for predicting CLNM in PTC.

著者

Mengyao Li Yijun Lin Tingting Bao Qihui Zhao Yulin Wang Manjing Li Ying Chen Yanlan Qian Lin Chen Daqian Zhu

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2022.01104, (Released:2022-03-19)

参考文献数

50

被引用文献数

5

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Given an increasing number of children with ASD, the need for inclusive education has rapidly increased in China. Since 2011, children with ASD have been eligible for inclusive education. However, little is known of the implementation process by key personnel. The purpose of the current study was to qualitatively explore elementary school teachers' experiences and perspectives on an inclusive education policy and practice for students with ASD. Participants were from 5 elementary schools in 2 districts in Shanghai. This study consisted of data collection in 2 phases. First, semi-structured, in-depth interviews were conducted with school psychologists and vice principals responsible for students' mental health for implementation of general inclusive education at each school. Second, focus groups of frontline teachers were assembled to hear their firsthand experiences. A thematic analysis was performed. Findings indicated that although all 5 schools had some ASD-related support, training and resources varied depending on whether learning in regular classrooms (LRC) was implemented. Frontline teachers in particular faced challenges implementing LRC, including the limited extent of LRC, tedious implementation procedures, and parents' misconceptions of LRC. Regardless of these challenges, frontline teachers tried to support students with ASD as much as they could. The current findings should help to advance the inclusive education policy in Shanghai, including increasing the availability of inclusive education resources and training for teachers, issuing specific LRC guidance, and reducing ASD-related stigma. This study is among the first to explore the implementation of inclusive education in urban China.