著者

Reiko Kudo Yuki Mikuniya Kazutaka Yamauchi Nami Shimizume Naomi Kudo Shinichi Goto Akira Sasaki Masataka Ando Yoshiko Takahashi Takuro Iwane Masahiko Tomiyama Atsushi Matsubara

出版者

Hirosaki University Graduate School of Medicine,Hirosaki Medical Society

雑誌

弘前医学 (ISSN:04391721)

巻号頁・発行日

vol.71, no.2-4, pp.138-145, 2021 (Released:2021-03-15)

参考文献数

16

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Objective: The incidence of dementia is increasing in developed countries, and early detection and treatment are important. Considering that olfactory disorders are correlated with cognitive dysfunction, olfactory testing might be a useful screening tool for dementia. In the present study, we investigated whether a simple olfactory test could predict the short-term progression of cognitive decline using data from a longitudinal study of a community-dwelling population. Subjects and Methods: Subjects were participants of the Iwaki Health Promotion Project, a community-based program aimed at improving average life expectancy. The subjects were examined using a 4-item modified Pocket Smell Test (mPST) and the Mini-Mental State Examination( MMSE) in 2016 and 2017. The relationship between the change in MMSE scores and olfactory identification ability in 2016 was analyzed in subjects with good MMSE scores in 2016. Results: Among participants in their 60s and 70s, the olfactory-impaired group showed significantly lower MMSE scores in 2017 than those of the good-olfaction group. Conclusion: Olfactory testing may be a tool for early detection of the onset of cognitive decline in elderly people.

著者

Masatoshi Iwamura Satoru Ide Kenya Sato Akihisa Kakuta Soichiro Tatsuo Atsushi Nozaki Tetsuya Wakayama Tatsuya Ueno Rie Haga Misako Kakizaki Yoko Yokoyama Ryoichi Yamauchi Fumiyasu Tsushima Koichi Shibutani Masahiko Tomiyama Shingo Kakeda

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

pp.mp.2022-0112, (Released:2023-03-16)

参考文献数

15

被引用文献数

4

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Purpose: Brain MRI with high spatial resolution allows for a more detailed delineation of multiple sclerosis (MS) lesions. The recently developed deep learning-based reconstruction (DLR) technique enables image denoising with sharp edges and reduced artifacts, which improves the image quality of thin-slice 2D MRI. We, therefore, assessed the diagnostic value of 1 mm-slice-thickness 2D T2-weighted imaging (T2WI) with DLR (1 mm T2WI with DLR) compared with conventional MRI for identifying MS lesions.Methods: Conventional MRI (5 mm T2WI, 2D and 3D fluid-attenuated inversion recovery) and 1 mm T2WI with DLR (imaging time: 7 minutes) were performed in 42 MS patients. For lesion detection, two neuroradiologists counted the MS lesions in two reading sessions (conventional MRI interpretation with 5 mm T2WI and MRI interpretations with 1 mm T2WI with DLR). The numbers of lesions per region category (cerebral hemisphere, basal ganglia, brain stem, cerebellar hemisphere) were then compared between the two reading sessions.Results: For the detection of MS lesions by 2 neuroradiologists, the total number of detected MS lesions was significantly higher for MRI interpretation with 1 mm T2WI with DLR than for conventional MRI interpretation with 5 mm T2WI (765 lesions vs. 870 lesions at radiologist A, < 0.05). In particular, of the 33 lesions in the brain stem, radiologist A detected 21 (63.6%) additional lesions by 1 mm T2WI with DLR.Conclusion: Using the DLR technique, whole-brain 1 mm T2WI can be performed in about 7 minutes, which is feasible for routine clinical practice. MRI with 1 mm T2WI with DLR enabled increased MS lesion detection, particularly in the brain stem.

著者

Tatsuya Ueno Ryoya Kimura Tomoya Kon Rie Haga Haruo Nishijima Jin-ichi Nunomura Masahiko Tomiyama

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0313-17, (Released:2018-02-28)

参考文献数

21

被引用文献数

3

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Miller Fisher syndrome (MFS) can be difficult to diagnose, particularly in mild cases where some of the standard triad of symptoms (external ophthalmoplegia, ataxia, and loss of deep tendon reflex) are absent. We herein report a case of the incomplete form of MFS diagnosed in a 54-year-old Japanese man who presented only with ataxia symptoms and was positive for the anti-GQ1b antibody. However, the patient also suffered from dysgeusia, a significant impairment of taste perception. We propose that dysgeusia in acute-onset ataxia cases may constitute an important clinical feature to aid in the diagnosis of the incomplete form of MFS.