- 著者
- Reiko Kudo Yuki Mikuniya Kazutaka Yamauchi Nami Shimizume Naomi Kudo Shinichi Goto Akira Sasaki Masataka Ando Yoshiko Takahashi Takuro Iwane Masahiko Tomiyama Atsushi Matsubara
- 出版者
- Hirosaki University Graduate School of Medicine,Hirosaki Medical Society
- 雑誌
- 弘前医学 (ISSN:04391721)
- 巻号頁・発行日
- vol.71, no.2-4, pp.138-145, 2021 (Released:2021-03-15)
- 参考文献数
- 16
Objective: The incidence of dementia is increasing in developed countries, and early detection and treatment are important. Considering that olfactory disorders are correlated with cognitive dysfunction, olfactory testing might be a useful screening tool for dementia. In the present study, we investigated whether a simple olfactory test could predict the short-term progression of cognitive decline using data from a longitudinal study of a community-dwelling population. Subjects and Methods: Subjects were participants of the Iwaki Health Promotion Project, a community-based program aimed at improving average life expectancy. The subjects were examined using a 4-item modified Pocket Smell Test (mPST) and the Mini-Mental State Examination( MMSE) in 2016 and 2017. The relationship between the change in MMSE scores and olfactory identification ability in 2016 was analyzed in subjects with good MMSE scores in 2016. Results: Among participants in their 60s and 70s, the olfactory-impaired group showed significantly lower MMSE scores in 2017 than those of the good-olfaction group. Conclusion: Olfactory testing may be a tool for early detection of the onset of cognitive decline in elderly people.
- 著者
- Sayaka Tomatsu Masaki Takahashi Masakazu Kakuni Gen Toshima Fumiko Kimura Junichiro Takahashi Yui Umekawa Akira Sasaki Keishi Hata
- 出版者
- Japan Science Society of Biological Macromolecules
- 雑誌
- Journal of Biological Macromolecules (ISSN:13472194)
- 巻号頁・発行日
- vol.21, no.1, pp.51, 2021 (Released:2021-01-20)
- 参考文献数
- 6
- 著者
- Keishi HATA TOMATSU Sayaka Masaki TAKAHASHI Akira SASAKI Yui UMEKAWA Kazuya MIYASHITA Kazumi OGURA Gen TOSHIMA Masahiro MAEDA Junichiro TAKAHASHI Masakazu KAKUNI
- 出版者
- Biomedical Research Press
- 雑誌
- Biomedical Research (ISSN:03886107)
- 巻号頁・発行日
- vol.41, no.1, pp.33-42, 2020-02-01 (Released:2020-02-22)
- 参考文献数
- 24
- 被引用文献数
- 5
We investigated lipid metabolism in PXB-cells, which are human primary hepatocytes isolated from liver-humanized mice, and HepG2 and HuH-7 human hepatoma cell lines. Lipoprotein levels were higher in PXB-cells than in the 2 other cell lines, and PXB-cells mainly released triglycerides and cholesterol as very low density lipoprotein (VLDL), similar to actual liver tissue, whereas the major lipoprotein released from the 2 hepatoma cell lines was LDL. RT-PCR analysis demonstrated that the gene expression levels of apolipoprotein B100 (ApoB100), the apolipoprotein of VLDL/LDL, were similar in PXB-cells and HepG2 cells, while the overexpression of ApoC2, ApoC3, and ApoE, which are components of VLDL, but not LDL, was observed in PXBcells. A protein immunoassay revealed that ApoB100 levels secreted from PXB-cells and HuH-7 cells were similar; however, ApoC3 levels were higher in PXB-cells than in the two other cell lines. We also examined the anti-lipidemic activities of fenofibrate using this assay system. Fenofibrate suppressed lipoprotein production from PXB-cells in a dose-dependent manner mainly by activating the β-oxidation pathway. These results suggest that PXB-cells produce high levels of lipoproteins and are suitable for screening anti-lipidemic agents.