著者

田中 雅史 Masashi Tanaka

出版者

甲南大学文学部

雑誌

甲南大學紀要. 文学編 = The Journal of Konan University. Faculty of Letters (ISSN:04542878)

巻号頁・発行日

no.165, pp.3-9, 2015-03-30

著者

田中 雅史 Masashi TANAKA

出版者

甲南大学文学部

雑誌

甲南大學紀要.文学編 = The Journal of Konan University. Faculty of Letters (ISSN:04542878)

巻号頁・発行日

no.170, pp.9-18, 2020-03-20

著者

Masashi Tanaka Shinya Masuda Yoshiyuki Matsuo Yousuke Sasaki Hajime Yamakage Kazuya Muranaka Hiromichi Wada Koji Hasegawa Tetsuya Tsukahara Akira Shimatsu Noriko Satoh-Asahara

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.32680, (Released:2016-03-18)

参考文献数

24

被引用文献数

1 14

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Aim: This study aims to determine the association between glucose metabolism and proinflammatory/anti-inflammatory properties of circulating monocytes or those of carotid plaques in patients who underwent carotid endarterectomy.Methods: Clinical characteristics and expression levels of proinflammatory/anti-inflammatory markers in circulating monocytes/carotid plaques were examined in 12 patients with diabetes and 12patients without diabetes.Results: Circulating monocytes from patients with diabetes revealed higher tumor necrosis factor (TNF)-α and lower interleukin (IL)-10 expression levels compared with those from patients without diabetes, which was also observed in carotid plaques from patients with diabetes. Hyperglycemia revealed positive and negative correlations with the ratios of IL-6+ and IL-10+ cells in carotid plaques, respectively. Moreover, we determined a positive correlation between circulating monocytes and carotid plaques with respect to TNF-α and IL-6 expressions.Conclusions: The inflammatory property of circulating monocytes was associated with that of carotid plaques. Hyperglycemia increased inflammatory properties and decreased anti-inflammatory properties of carotid plaques.

著者

田中 雅史 Masashi Tanaka

出版者

甲南大学文学部

雑誌

甲南大學紀要.文学編 = The Journal of Konan University. Faculty of Letters (ISSN:04542878)

巻号頁・発行日

vol.161, pp.3-14, 2011-03-30

著者

田中 雅史 Masashi TANAKA

出版者

甲南大学文学部

雑誌

甲南大學紀要. 文学編 = The Journal of Konan University. Faculty of Letters (ISSN:04542878)

巻号頁・発行日

no.165, pp.3-9, 2015-03-30

著者

田中 雅史 Masashi Tanaka

出版者

甲南大学文学部

雑誌

甲南大學紀要. 文学編 = The Journal of Konan University. Faculty of Letters (ISSN:04542878)

巻号頁・発行日

no.169, pp.9-17, 2019-03-30

著者

田中 雅史 Masashi TANAKA

出版者

甲南大学文学部

雑誌

甲南大學紀要. 文学編 = The Journal of Konan University. Faculty of Letters (ISSN:04542878)

巻号頁・発行日

no.166, pp.21-28, 2016-03-30

著者

田中 雅史 Masashi TANAKA

出版者

甲南大学文学部

雑誌

甲南大學紀要.文学編 = The Journal of Konan University. Faculty of Letters (ISSN:04542878)

巻号頁・発行日

vol.170, pp.9-18, 2020-03-20

著者

田中 雅史 Masashi Tanaka

出版者

甲南大学文学部

雑誌

甲南大學紀要. 文学編 = The journal of Konan University (ISSN:04542878)

巻号頁・発行日

no.166, pp.21-28, 2015

著者

田中 雅史 Masashi TANAKA

出版者

甲南大学文学部

雑誌

甲南大學紀要.文学編 = The Journal of Konan University. Faculty of Letters (ISSN:04542878)

巻号頁・発行日

vol.153, pp.57-83, 2008-03-15

著者

Akira Sezai Makoto Taoka Shunji Osaka Yoshiki Kitazumi Keito Suzuki Keita Kamata Masashi Tanaka

出版者

The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery

雑誌

Annals of Thoracic and Cardiovascular Surgery (ISSN:13411098)

巻号頁・発行日

pp.oa.20-00213, (Released:2020-11-18)

参考文献数

23

被引用文献数

4

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Purpose: Recently, guidelines recommended the use of direct oral anticoagulants (DOACs) for the management of non-valvular atrial fibrillation (NVAF). Postoperative atrial fibrillation (POAF) is the most common post-surgical complication of cardiac surgery, but the efficacy and safety of DOAC for POAF have rarely been investigated. We conducted a prospective observational study to investigate the efficacy and safety of DOAC administered immediately after POAF.Materials and Methods: In all, 135 patients that experienced POAF after cardiac surgery were treated with a DOAC. Primary endpoints were either bleeding or thromboembolic events. Secondary endpoints included changes in hemoglobin (Hb), prothrombin time (PT), activated partial thromboplastin time (APTT), serum creatinine (sCr), estimated glomerular filtration rate (eGFR), and pleural/pericardial effusion.Results: Patients were treated with apixaban (n = 31), edoxaban (n = 87), and rivaroxaban (n = 17). Major bleeding (p = 0.011) and gastrointestinal (GI) bleeding (p = 0.047) were significantly more frequent in the rivaroxaban group. Stroke was observed in one rivaroxaban group patient and none in the other two groups.Conclusion: DOAC as anticoagulation therapy for the early intervention of POAF following cardiac surgery is associated with a low incidence of major bleeding; a favorable safety profile and excellent efficacy were demonstrated for DOAC. Furthermore, our results indicate that the safety and efficacy of apixaban and edoxaban are better than rivaroxaban.

著者

Akira Sezai Satoshi Unosawa Makoto Taoka Shunji Osaka Hisakuni Sekino Masashi Tanaka

出版者

The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery

雑誌

Annals of Thoracic and Cardiovascular Surgery (ISSN:13411098)

巻号頁・発行日

pp.oa.19-00162, (Released:2019-11-21)

参考文献数

23

被引用文献数

7

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Background: The TROFEO trial demonstrated that febuxostat causes greater and more rapid reduction of serum uric acid (s-UA) than topiroxostat. We compared these drugs in patients with chronic kidney disease (CKD) by sub-analysis of the TROFEO trial.Methods: This sub-analysis targeted patients with an estimated glomerular filtration rate (eGFR) ≤60 mL/min/1.73 m2. The primary endpoint was the s-UA level. Secondary endpoints included creatinine, eGFR, urinary albumin, cystatin-C, oxidized low-density lipoprotein (Ox-LDL), eicosapentaenoic acid/arachidonic acid ratio, lipid biomarkers, high-sensitivity C-reactive protein, and B-type natriuretic peptide (BNP).Results: There was no significant difference of s-UA between the two groups either before or after treatment. However, s-UA did not exceed 6.0 mg/dL in febuxostat group during the study period, but it exceeded this level in seven patients from topiroxostat group, with the number being significantly higher in topiroxostat group. Serum creatinine (s-Cr) and eGFR were significantly better after 6 months of febuxostat treatment compared with topiroxostat Cystatin-C was significantly lower after 6 months of febuxostat treatment compared with topiroxostat. The Ox-LDL was significantly lower after 3 and 6 months of febuxostat treatment compared with topiroxostat.Conclusion: Febuxostat had stronger renoprotective and antioxidant effects than topiroxostat in patients with hyperuricemia and CKD.

著者

田中 眞佐志 タナカ マサシ Masashi Tanaka

出版者

浦和大学・浦和大学短期大学部

雑誌

浦和論叢 (ISSN:0915132X)

巻号頁・発行日

no.52, pp.71-84, 2015-02

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日本文化は、激しい外圧とじっくりとした内燃(著しく外国の影響を受けた外圧の時期と、後世「日本的」と形容される特質を醸成するいわば内燃の時期)を繰り返しながら形成されてきた。後者の代表が室町文化・江戸文化である。従来、江戸時代の文化史的区分は、元禄期(17世紀後半~18世紀初期)を中心とする前期と文化文政期(19世紀前半)を中心とする後期の二分法が行われ、18世紀(1720年代~89年=享保~宝暦~天明)は2つの文化の谷間と捉えられてきた。本論はこの谷間の時期=享保~宝暦~天明期を上方文化と江戸文化が融合する、いわば江戸文化のピークと捉え、その転換点を明暦の大火後の都市造りに求めた。そして、江戸が城下町ではなく、巨大都市に発展しながら、独特の精神的価値基準を有する江戸の町人社会が形成されていったことに照準し、江戸時代の前半と後半の幕府政治・経済社会構造の根本的相違を俯瞰しながら、江戸時代にまつわる誤解を提起・修正した。

著者

田中 雅史 Masashi Tanaka

出版者

甲南大学文学部

雑誌

甲南大學紀要.文学編 = The Journal of Konan University. Faculty of Letters (ISSN:04542878)

巻号頁・発行日

vol.162, pp.9-20, 2012-03-30

著者

田中 雅史 Masashi TANAKA

出版者

甲南大学文学部

雑誌

甲南大學紀要. 文学編 = The journal of Konan University (ISSN:04542878)

巻号頁・発行日

no.166, pp.21-28, 2015