著者

Naoki Hirose Miho Ishimaru Kojiro Morita Hideo Yasunaga

出版者

Society for Clinical Epidemiology

雑誌

Annals of Clinical Epidemiology (ISSN:24344338)

巻号頁・発行日

vol.2, no.1, pp.13-26, 2020 (Released:2020-05-14)

参考文献数

95

被引用文献数

7 40

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BACKGROUNDElectronic health databases are increasingly used for research purposes. The Japanese National Database of Health Insurance Claims and Specific Health Checkups (NDB) is a large national administrative claims database. We reviewed published original articles that used the NDB.METHODSStudies published from January 2011 to June 2019 using the NDB were identified through PubMed and the academic product lists of the NDB, following the PRISMA guidelines.RESULTS68 studies were included in our review (43 were in English and 25 were in Japanese). The first NDB study in English was published in 2015, which was 4 years after the NDB was released for research purposes. The average annual growth rate of the number of NDB studies in English was 237% after the first publication of an NDB study in English. Descriptive studies were the most common study design (n = 42), and the Clinical Medicine was the most common research area (n = 18). The study strength most frequently mentioned by authors of the NDB studies was the large sample size. In terms of limitations, authors most frequently mentioned the lack of important data and validation studies.CONCLUSIONSSince its release, the NDB has increasingly attracted attention, and the number of studies using the NDB has grown rapidly. The large sample size and wide array of health care data in the NDB enabled researchers to conduct health service research in various research areas with several study designs. Finally, our review suggests to policy makers that administrative database should be constructed and managed with the environment which promote researchers access to the database and link it to other databases. Although the protection of respondents’ privacy should be carefully considered, higher accessibility and data linkage may maximize the potential of the administrative database and may enable researchers to produce more valuable health service researches for policy making in health care.

著者

Genta Ueno Tomoyuki Higuchi Takashi Kagimoto Naoki Hirose

出版者

(公社)日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.3, pp.5-8, 2007 (Released:2007-01-31)

参考文献数

19

被引用文献数

7 17

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We report an application of the ensemble Kalman filter (EnKF) and smoother (EnKS) to an intermediate coupled atmosphere-ocean model of Zebiak and Cane, into which the sea surface height (SSH) anomaly observations by TOPEX/POSEIDON (T/P) altimetry are assimilated. Smoothed estimates of the 54,403 dimensional state are obtained from 1,981 observational points with 2,048 ensemble members. While assimilated data are SSH anomalies alone, the estimated sea surface temperature (SST) anomalies reproduce primary temporal characteristics of the actual SST. The smoothed estimate of the zonal wind anomalies is also consistent with the observation except for the westerly anomalies in the western Pacific.

著者

Naoki HIROSE Kazuyuki UCHIDA Satoru MATSUNAGA James K. CHAMBERS Hiroyuki NAKAYAMA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0381, (Released:2014-11-06)

被引用文献数

8

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Choroid plexus tumor (CPT) is a primary intracranial neoplasm of the choroid plexus epithelium in the central nervous system. In the current World Health Organization classification, CPT is classified into two categories; choroid plexus papilloma (CPP) and carcinoma (CPC). In the present study, we investigated immunohistochemical expressions of N-cadherin, E-cadherin and β-catenin in 5 canine CPT cases (1 disseminated CPC, 2 CPCs and 2 CPPs). One CPP case was positive for N-cadherin and β-catenin, but negative for E-cadherin. The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin. The other cases were positive for the three molecules examined. These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

著者

Naoki HIROSE Kazuyuki UCHIDA Hideyuki KANEMOTO Koichi OHNO James K. CHAMBERS Hiroyuki NAKAYAMA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0083, (Released:2014-04-09)

被引用文献数

1 43

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To determine the incidence of hepatic diseases in dogs and cats in Japan, a retrospective study was performed using data of 463 canine and 71 feline liver biopsies at the Veterinary Medical Center of the University of Tokyo. The most common canine hepatic disease was microvascular dysplasia (MVD) and occupied 29.4% of all diagnoses. This terminology might contain “real” MVD and primary portal vein hypoplasia, because these two conditions were difficult to be clearly distinguished histopathologically. Parenchymal and interstitial hepatitis and primary hepatic tumors accounted for 23.5% and 21.0% of the diagnoses, respectively. Parenchymal and interstitial hepatitis occupied 34.1% of non-proliferative canine hepatic diseases, while hepatocellular adenoma and carcinoma were 26.6% and 24.5% of proliferative hepatic diseases, respectively. Breed-specificity was seen in MVD for Yorkshire terrier, Papillon and Toy poodle, in hepatitis for Doberman pinscher and Labrador retriever, in cholangiohepatitis for American cocker spaniel, Miniature schnauzer and Pomeranian, in hepatocellular adenoma for Golden retriever and Shiba and in hepatocellular carcinoma for Shih Tzu. The most common feline liver disease was parenchymal and interstitial hepatitis (45.1% of all diagnoses). Among feline hepatitis, neutrophilic cholangiohepatitis (23.9%), lymphocytic cholangiohepatitis (14.1%) and chronic hepatitis (5.6%) were recorded. Adult polycystic liver disease was 5.6%. Among proliferative diseases in the feline liver (11.3% of the all), lymphoma (4.2%) and primary epithelial tumors (4.2%) including hepatocellular carcinoma, cholangiocellular adenoma and cholangiocellular carcinoma were observed. Hepatic degeneration was 14.1%, and MVD was 12.7%, respectively.

著者

Naoki Hirose Ken-ichi Fukudome

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.2, pp.61-63, 2006 (Released:2006-04-15)

参考文献数

8

被引用文献数

30 34

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Seasonal predictions of rain or snowfall are usually too uncertain at regional scales. We suggest utilizing subsurface ocean measurements to improve long-term weather forecasts. The example we give is that regional snowfall in Japan can be predicted by a simple regression from an acoustic Doppler current profiler attached to a regular ferryboat to observe the transport of the Tsushima Warm Current. The lag correlation is shown to exceed 0.75 attributed to the simple underling marine meteorology and regional oceanography. The relationship certainly improves seasonal precipitation estimates led by the winter monsoon absorbing the latent heat from the Japan Sea. We predict there will be less snowfall this winter of 2005/2006 than in 2004/2005 despite the heavy snowfall event in the last December.