著者

Yuka Sumikawa Noriko Yamamoto-Mitani

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

vol.15, no.1, pp.55-57, 2021-02-28 (Released:2021-03-15)

参考文献数

9

被引用文献数

9

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Transitional care is indispensable in successfully transitioning patients from hospital to home and preventing adverse events during this process. There were restricted services in several hospitals for minimizing the spread of COVID-19. Therefore, hospitals could not provide adequate transitional care that possibly resulted in poor post-discharge outcomes in patients. Some hospitals have now combined infection prevention with face-to-face opportunities, i.e., requiring reservations for transitional care consultation and restricting pre-discharge conferences. Several hospitals started providing pre-discharge conferences using apps, where patients/family caregivers and care teams could have face-to-face discussions about medical and nursing care plans, goals, and preferences. However, building a relationship between patient/family and medical/nursing staff and providing decision-making, psychological support, and risk assessment generally performed in person are still in demand. New hybrid strategies should be developed and evaluated to provide transitional care while using online systems and minimal face-to-face support during the pandemic.

著者

山本 野理子 Noriko Yamamoto

雑誌

人文論究 (ISSN:02886677)

巻号頁・発行日

vol.63, no.4, pp.51-75, 2014-02-10

著者

Riho IWASAKI-MOTEGI Kyoko YOSHIOKA-MAEDA Chikako HONDA Noriko YAMAMOTO-MITANI

出版者

Japanese Society of Public Health

雑誌

日本公衆衛生雑誌 (ISSN:05461766)

巻号頁・発行日

vol.69, no.6, pp.417-423, 2022-06-15 (Released:2022-06-15)

参考文献数

27

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Objective This study aimed to explore the support extended by prefectural public health nurses (PHNs) toward the human resource development (HRD) of municipal PHNs in Japan.Methods We performed a qualitative descriptive study involving nine prefectural PHNs from April 2019 to May 2020. The data were collected through semi-structured interviews using an interview guide, described qualitatively, coded, and then categorized.Results Five categories were extracted. “Clarifying the needs and problems related to HRD and daily PHN activities in the municipalities,” “Creating an environment where all municipal PHNs have equal opportunities for off-the-job training,” and “Helping municipal PHNs recognize the meaning of practice and develop an evaluation perspective” were extracted from the prefectural government PHNs and prefectural health center (HC) PHNs. “Clarifying problems and future prospects to encourage the growth of PHNs” and “Creating an environment where the significance and value of the activities of PHNs are recognized within the organization and HRD can easily take place” were extracted from the HC PHNs.Conclusion Much of the HRD support provided by the prefectural PHNs to the municipal PHNs was analogous to the PHN activities provided to the community and residents. To promote HRD effectively, prefectural PHNs should apply their individual care skills to the HRD of municipal PHNs.

著者

Kazuyuki Furuya Noriko Yamamoto Yuki Ohyabu Teruyuki Morikyu Hirohide Ishige Michael Albers Yasuhisa Endo

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.36, no.3, pp.442-451, 2013-03-01 (Released:2013-03-01)

参考文献数

56

被引用文献数

8 26

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Selective androgen receptor modulators (SARMs) comprise a new class of molecules that induce anabolic effects with fewer side effects than those of other anabolic agents. We previously reported that the novel SARM S-101479 had a tissue-selective bone anabolic effect with diminished side effects in female animals. However, the mechanism of its tissue selectivity is not well known. In this report, we show that S-101479 increased alkaline phosphatase activity and androgen receptor (AR) transcriptional activity in osteoblastic cell lines in the same manner as the natural androgen ligand dihydrotestosterone (DHT); conversely, stimulation of AR dimerization was very low compared with that of DHT (34.4%). S-101479 increased bone mineral content in ovariectomized rats without promoting endometrial proliferation. Yeast two-hybrid interaction assays revealed that DHT promoted recruitment of numerous cofactors to AR such as TIF2, SRC1, β-catenin, NCoA3, gelsolin and PROX1 in a dose-dependent manner. SARMs induced recruitment of fewer cofactors than DHT; in particular, S-101479 failed to induce recruitment of canonical p160 coactivators such as SRC1, TIF2 and notably NCoA3 but only stimulated binding of AR to gelsolin and PROX1. The results suggest that a full capability of the AR to dimerize and to effectively and unselectively recruit all canonical cofactors is not a prerequisite for transcriptional activity in osteoblastic cells and resulting anabolic effects in bone tissues. Instead, few relevant cofactors might be sufficient to promote AR activity in these tissues.