著者
Okita Keisuke Yamanaka Shinya
出版者
Elsevier Inc.
雑誌
Experimental cell research (ISSN:00144827)
巻号頁・発行日
vol.316, no.16, pp.2565-2570, 2010-10-01
被引用文献数
52

Somatic cells can be reprogrammed into pluripotent stem cells by introducing a combination of several transcription factors. The induced pluripotent stem (iPS) cells from a patient's somatic cells could be useful source of cells for drug discovery and cell transplantation therapies. However, most human iPS cells are made by viral vectors, such as retrovirus and lentivirus, which integrate the reprogramming factors into host genomes and may increase the risk of tumor formation. Studies of the mechanisms underlying the reprogramming and establishment of non-integration methods contribute evidence to resolve the safety concerns associated with iPS cells. On the other hand, patient-specific iPS cells have already been established and used for recapitulating disease pathology.
著者
Kitazawa Koji Hikichi Takafusa Nakamura Takahiro Mitsunaga Kanae Tanaka Azusa Nakamura Masahiro Yamakawa Tatsuya Furukawa Shiori Takasaka Mieko Goshima Naoki Watanabe Akira Okita Keisuke Kawasaki Satoshi Ueno Morio Kinoshita Shigeru Masui Shinji
出版者
Elsevier Inc.
雑誌
Cell reports (ISSN:22111247)
巻号頁・発行日
vol.15, 2016-04-28
被引用文献数
11

ヒト角膜上皮分化を規定している新分子を発見-OVOL2は角膜上皮における上皮性恒常維持に関与-. 京都大学プレスリリース. 2016-05-09.
著者
Yoshida Yoshinori Takahashi Kazutoshi Okita Keisuke Ichisaka Tomoko Yamanaka Shinya
出版者
Elsevier
雑誌
Cell Stem Cell (ISSN:19345909)
巻号頁・発行日
vol.5, no.3, pp.237-241, 2009-08
被引用文献数
4 382

低酸素濃度培養によるiPS細胞樹立効率の改善 -効率的な樹立方法開発に貢献する知見をCell Stem Cellに報告-. 京都大学プレスリリース. 2009-08-28. http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2009/090828_2.htm