著者

稲谷 昌之 後藤 浩之 盛川 仁 小倉 祐美子 徳江 聡 Xin-rui ZHANG 岩崎 政浩 荒木 正之 澤田 純男 ZERVA Aspasia

出版者

公益社団法人 土木学会

雑誌

土木学会論文集A1(構造・地震工学) (ISSN:21854653)

巻号頁・発行日

vol.69, no.4, pp.I_758-I_766, 2013 (Released:2013-06-19)

参考文献数

7

被引用文献数

1

---

2011年東北地方太平洋沖地震では内陸部の宮城県大崎市古川地区において地震動による構造物被害が多く発生した.古川地区の中でも一部地域に被害が集中していることから,その原因の一つとして地盤震動特性の違いが考えられる.そこで,本研究では古川地区に展開されている超高密度地震観測のデータを利用して地盤震動特性の違いを検討した,古川地区内の地盤が各点毎に構造の異なる一次元水平成層構造であると仮定して地盤モデルを推定したところ,被害が集中した地域において表層地盤が厚くなる傾向が見られた.ただし,推定した地盤モデルを用いて時刻歴観測波形の再現を試みたところ,一部の観測点には再現出来ない特徴的なフェーズが認められた.このことは,表層の地盤構造を一次元水平成層構造でモデル化するという従来の枠組みでは,古川地区の地震動を説明する上で本質的に不十分であることを示唆している.

著者

TOSHIO OTANI YOSHINORI MINAMI TERUYOSHI MARUNAKA RUI ZHANG MEI-YU XIE

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.41, no.11, pp.1696-1698, 1988-11-25 (Released:2006-04-19)

参考文献数

11

被引用文献数

9 5

著者

TOSHIO OTANI YOSHINORI MINAMI TERUYOSHI MARUNAKA Rui ZHANG MEI-YU XIE

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.41, no.11, pp.1580-1585, 1988-11-25 (Released:2006-04-19)

参考文献数

15

被引用文献数

57 67

---

A new macromolecular antibiotic C-1027 was obtained from the broth filtrate of Streptomyces ghbisporus C-1027 by precipitation with ammonium sulfate, DEAE-cellulose column chromatography and gel filtration chromatography on a Sephadex G-75 column. This antibiotic, prepared as a white powder, is an acidic polypeptide having an isoelectric point of pH 3.5-3.7 and a molecular weight of 15, 000 as determined by SDS-polyacrylamide gel electrophoresis and gel filtration chromatography. The acid hydrolysate of the purified antibiotic C-1027 contained no methionine or tryptophan. From the physico-chemical data, it may be considered to possess a very labile non-protein chromophore.

著者

JILAN HU YU-CHUAN XUE MEI-YU XIE RUI ZHANG TOSHIO OTANI YOSHINORI MINAMI YUJI YAMADA TERUYOSHI MARUNAKA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.41, no.11, pp.1575-1579, 1988-11-25 (Released:2006-04-19)

参考文献数

14

被引用文献数

77 102

---

Strain C-1027, an actinomycete isolated from a soil sample collected in China, was found to produce the new antibiotic, C-1027. From taxonomical studies on its morphological, cultural and physiological characteristics, this antibiotic-producing strain was identified as Streptomyces ghbisporus C-1027. Antibiotic C-1027 has antimicrobial activity against most Gram-positive bacteria but not against Mycobacterium sp. or Gram-negative bacteria. This antibiotic shows remarkable activity in spermatogonial assay and potent cytotoxicity against KB carcinoma cells in vitro, and exhibits inhibition on transplantable tumors in mice.

著者

Chunmei Geng Pingli Li Xuwang Chen Guiyan Yuan Nan Guo Huanjun Liu Rui Zhang Ruichen Guo

出版者

バイオ&ソーシャル・サイエンス推進国際研究交流会

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2017.01029, (Released:2017-04-17)

参考文献数

23

被引用文献数

7

---

To determine the feasibility of using a nanoparticle immunoassay for clinical therapeutic drug monitoring (TDM) of docetaxel concentrations, a sensitive and simple method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established to measure the docetaxel concentration in human plasma and the results of LC-MS/MS and the immunoassay were compared. Docetaxel and paclitaxel (the internal standard, or IS) in human plasma were extracted through protein precipitation, separated on a Diamonsil C18 column (150 mm × 4.6 mm, 5 μm), ionized with positive ions, and detected with LC-MS/MS in multi-reaction monitoring (MRM) mode. Plasma samples from 248 cancer patients were assayed with LC-MS/MS and a nanoparticle immunoassay. Data from the samples were analyzed with the statistical software SPSS and the software MedCalc. Results indicated that the calibration curve of the validated method of LC-MS/MS was linear over the range of 10-2,000 ng/mL, with an lowest limit of quantitation (LLOQ) of 10 ng/mL, and the intra- and inter- day precision and accuracy were both < ± 15%. Comparison of the two methods indicated that results of the LC-MS/MS were closely related to those of the nanoparticle immunoassay, with a correlation coefficient (R) of 0.965 and acceptable 95% confidence intervals (CI) of ‒ 231.7-331.1 ng/mL. Overall, the established method of LC-MC/MS and the nanoparticle immunoassay were both suitable for measurement of the docetaxel concentration in human plasma, and the immunoassay was far more cost-effective and better at clinical TDM of docetaxel in clinical practice.