- 著者
- Naoshi Hirata Shiro Ohmi Shin'ichi Sakai Kei Katsumata Satoshi Matsumoto Tetsuo Takanami Akira Yamamoto Takashi Iidaka Taku Urabe Mayumi Sekine Tooru Ooida Fumihito Yamazaki Hiroshi Katao Yasuhiro Umeda Masao Nakamura Norihiko Seto Takeshi Matsushima Hiroshi Shimizu Japanese University Group of the Urgent Joint
- 出版者
- The Seismological Society of Japan, The Volcanological Society of Japan, The Geodetic Society of Japan
- 雑誌
- Journal of Physics of the Earth (ISSN:00223743)
- 巻号頁・発行日
- vol.44, no.4, pp.317-328, 1996 (Released:2009-04-30)
- 参考文献数
- 21
- 被引用文献数
- 41 43
A disastrous earthquake with a magnitude of 7.2 hit the southern part of Hyogo Prefecture on January 17, 1995. The mainshock was located on an active fault of the Arima-Takatsuki-Rokko fault system. Its focal mechanism was consistent with a right-lateral strike-slip fault trending N40°E. Three days after the occurrence of the mainshock, we started to install a highly dense seismic array in and around the fault area of the quake. Two permanent regional seismic networks of more than 30 stations covered the entire area of 200 km × 200 km. The temporarily installed array of 27 stations spanned the fault area of 15 km × 50 km. All data were telemetered to a temporary observation center at Uji. We located about 3, 100 aftershocks in real time for 1 month using an Internet connection between seismic networks. The aftershock area extended 70 km trending northeast to southwest. Hypocenters determined by the network were delivered automatically through the Internet. We found that the aftershock distribution was heterogeneous in space and time: seven clusters of hypocenters were identified and temporary variation in the rate of occurrence of aftershocks had a periodic component with periods of a half of day, 1 day, and 3 days, that are superimposed on decaying of the rate following Omori's law.
- 著者
- Yumi KONDO Kazuaki TAKASHIMA Satoshi MATSUMOTO Masahiro SHIBA Tomoko OTSUKI Gen KINOSHITA Joseph ROSENTEL Sheila J. GROSS Candis FLEISHMAN Yoshihisa YAMANE
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.74, no.10, pp.1283-1289, 2012 (Released:2012-11-02)
- 参考文献数
- 18
- 被引用文献数
- 3 11 1
Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator’s judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.
- 著者
- Tomoaki NAITO Masatoshi MORIKAWA Mayuko YAMAMOTO-FUJIMURA Akira IWATA Ayaka MAKI Noriko KATO-NAGAOKA Kosuke OANA Junko KIYOSHIMA-SHIBATA Yumi MATSUURA Rumi KAJI Osamu WATANABE Kan SHIDA Satoshi MATSUMOTO Tetsuji HORI
- 出版者
- BMFH Press
- 雑誌
- Bioscience of Microbiota, Food and Health (ISSN:21863342)
- 巻号頁・発行日
- vol.42, no.1, pp.65-72, 2023 (Released:2023-01-01)
- 参考文献数
- 39
- 被引用文献数
- 1
Mononuclear phagocytic cells (MPCs) are classified into monocytes (Mos)/macrophages and dendritic cells (DCs) based on their functions. Cells of MPCs lineage act as immune modulators by affecting effector cells, such as NK cells, T cells, and B cells. This study aimed to investigate the effects of Lacticaseibacillus paracasei strain Shirota (LcS) ingestion on peripheral MPCs, particularly on their expression of functional cell-surface molecules enhanced in healthy adults. Thus, twelve healthy office workers consumed a fermented milk drink containing 1.0 × 1011 cfu of LcS (LcS-FM) or a control unfermented milk drink (CM) once a day for 6 weeks. Peripheral blood mononuclear cells (PBMCs) were prepared from blood samples, and immune cells and functional cell-surface molecules were analyzed. We observed remarkable differences in the expression of HLAABC, MICA, CD40, and GPR43 in plasmacytoid DCs (pDCs) between the LcS-FM and CM groups, whereas no difference was found in CD86 or HLADR expression. The LcS-FM group exhibited higher CD40 expression in both conventional DCs (cDCs) and Mos, especially in type 2 conventional DCs (cDC2s) and classical monocytes (cMos); higher percentages of cMos, intermediate monocytes (iMos), and nonclassical monocytes; and higher numbers of cMos and iMos in PBMCs than the CM group. LcS ingestion increased the expression of HLAABC, MICA, CD40, and GPR43 in pDCs and CD40 in cDCs and Mos, particularly cDC2s and cMos. These results suggest that LcS modulates the function of MPCs that may lead to the regulation of immune effector functions in healthy adults.
- 著者
- Yumi KONDO Kazuaki TAKASHIMA Satoshi MATSUMOTO Masahiro SHIBA Tomoko OTSUKI Gen KINOSHITA Joseph ROSENTEL Sheila J. GROSS Candis FLEISHMAN Yoshihisa YAMANE
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.11-0306, (Released:2012-05-31)
- 被引用文献数
- 3 11
Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator’s judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.