著者

Takashi Wada Katsuya Ichinose Hiroya Higuchi

出版者

JAPANESE SOCIETY OF APPLIED ENTOMOLOGY AND ZOOLOGY

雑誌

Applied Entomology and Zoology (ISSN:00036862)

巻号頁・発行日

vol.34, no.3, pp.365-370, 1999-08-25 (Released:2008-02-07)

参考文献数

25

被引用文献数

12 16

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Damage to direct-sown rice by th apple snail, Pomacea canaliculata, was investigated in two semi-field experiments using rain-free experimental plots (each 2 m2 in area). Four snails (2 snails/m2), with shell heights of approximately 19 mm or 24 mm, were released in the plots at the time of sowing When the plots were irrigated soon after sowing (0 or 4 days after sowing), the snails fed avidly on young seedlings and no plants became established Drainage after sowing greatly reduced snail damage. Eighty seven to 94% of plants as compared to the control plots without snails were established when plots were drained for two weeks. Three weeks of drainage could almost prevent damage by snails (95-99% of plant establishment) when the plant age was at about the 5.0 leaf stage. Snail damage was more severe when herbicide was applied. Water management after sowing in direct-seeded rice is discussed in view of reducing snail damage.

著者

Manami Hoshi Misa Ishiyama Takashi Wada Kenchi Hase Masayuki Itoh Takashi Kikuiri Tetsuo Shirakawa

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.65, no.2, pp.96-101, 2023 (Released:2023-03-30)

参考文献数

24

被引用文献数

1

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Purpose: Methyl-CpG binding protein 2 (MeCP2)-deficient (Mecp2−/y) mice exhibit apneas that resemble respiratory abnormalities observed in Rett syndrome (RTT) patients. The present study aimed to clarify whether Mecp2−/y mice show diurnal variations in apnea as seen in RTT and how the MeCP2 deficiency affects monoaminergic systems that control breathing.Methods: In 7-week-old Mecp2−/y mice, 24 h variation of apnea and effects of milnacipran, a serotonin/noradrenaline reuptake inhibitor, on the apnea were evaluated. The number of vesicular monoamine transporter 2 (VMAT2)-immunoreactive puncta in the caudal medulla was counted. Further, the effects of valproate (VPA) on the expression of tyrosine hydroxylase (TH) mRNA in the ventrolateral medulla of mice were assessed by RT-qPCR.Results: Apnea occurred more frequently during the light phase under a 12:12 h light/dark environment in Mecp2−/y mice and milnacipran reduced apnea during the light phase but not during the dark phase. The number of VMAT2-immunoreactive puncta was reduced in Mecp2−/y mice. VPA treatment significantly increased TH mRNA expression in Mecp2−/y mice.Conclusion: Alteration of monoaminergic systems in the caudal medulla of Mecp2−/y mice is potentially relevant to the light-sensitive diurnal increase of apnea, and an improvement in monoaminergic neurotransmission can ameliorate the diurnal increase of apnea in Mecp2−/y mice.

著者

Kengo Furuichi Miho Shimizu Akinori Hara Tadashi Toyama Takashi Wada

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.57, no.23, pp.3345-3350, 2018-12-01 (Released:2018-12-01)

参考文献数

23

被引用文献数

3 22

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Diabetic kidney disease is the main cause of end-stage kidney disease. However, the clinical manifestations of diabetic kidney disease are diverse. Therefore, the clinical classification of diabetic kidney disease is clinically important and valuable. In Japan, two clinical staging systems divided by the estimated glomerular filtration rate (eGFR) and albuminuria can be used for diabetic kidney disease: the chronic kidney disease (CKD) risk classification and the Japanese classification of diabetic nephropathy. The Japanese classification of diabetic nephropathy and the CKD risk classification are similar; however, these two classification systems show different frequencies of outcomes. For example, the frequency of the kidney outcomes in stage 4 of the Japanese classification of diabetic nephropathy was found to be higher than that in the red stage of the CKD risk classification (composite kidney events: stage 4=32.0/100 person-years, red =14.5/100 person-years). However, there were no marked differences in the speed or rate of decline in the kidney function (speed: stage 4=6.8 mL/min/1.73 m2/year, red =5.8 mL/min/1.73 m2/year; rate: stage 4=38.8%/year, red =34.3%/year) or in the pathological changes between the two classifications. These data indicate that each stage of these clinical classification systems has characteristic clinical and pathological features. Therefore, it is important to understand each characteristic feature and use each classification system appropriately.

著者

Mitsuaki Isobe Koichi Amano Yoshihiro Arimura Akihiro Ishizu Shuichi Ito Shinya Kaname Shigeto Kobayashi Yoshinori Komagata Issei Komuro Kimihiro Komori Kei Takahashi Kazuo Tanemoto Hitoshi Hasegawa Masayoshi Harigai Shouichi Fujimoto Tatsuhiko Miyazaki Tetsuro Miyata Hidehiro Yamada Akitoshi Yoshida Takashi Wada Yoshinori Inoue Haruhito A. Uchida Hideki Ota Takahiro Okazaki Mitsuho Onimaru Tamihiro Kawakami Reiko Kinouchi Atsushi Kurata Hisanori Kosuge Ken-ei Sada Kunihiro Shigematsu Eiichi Suematsu Eijun Sueyoshi Takahiko Sugihara Hitoshi Sugiyama Mitsuhiro Takeno Naoto Tamura Michi Tsutsumino Hiroaki Dobashi Yoshikazu Nakaoka Kenji Nagasaka Yasuhiro Maejima Hajime Yoshifuji Yoshiko Watanabe Shoichi Ozaki Takeshi Kimura Hiroshi Shigematsu Keiko Yamauchi-Takihara Toyoaki Murohara Shin-ichi Momomura on behalf of the JCS Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.84, no.2, pp.299-359, 2020-01-24 (Released:2020-01-24)

参考文献数

368

被引用文献数

3 54

著者

Takashi Wada Tsutomu Fukumoto Kyoko Ito Yasutaka Hasegawa Takanobu Osaki Hideyuki Ban

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.48, no.9, pp.647-655, 2009 (Released:2009-05-01)

参考文献数

20

被引用文献数

7 8

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Objective Metabolic syndrome is associated with a high risk of cardiovascular morbidity and mortality. The predominant cause of metabolic syndrome is an unhealthy lifestyle. Healthy habits are represented by Breslow's 7 healthy practices, Morimoto's 8 items and Ikeda's 6 healthy habits. This study was done to determine which set of healthy habits was most likely to result in a reduced risk of developing the metabolic syndrome. Methods From April 1, 2000 through March 31, 2007, 6,765 males and 2,789 females underwent a medical check-up at Jikei University Hospital in Japan. They completed a simple, self-administered lifestyle questionnaire based on the 3 classifications of healthy habits. The responses were divided into 3 groups (poor, moderate and favorable) according to each of the healthy habit criteria. The incidence of metabolic syndrome was defined in participants who were newly diagnosed during the follow-up using Japanese-specific diagnostic criteria. The Kaplan-Meier cumulative 7-year incidence was calculated. Kaplan-Meier curves were compared using the long-rank test adjusted for age. Results In females, Breslow's, Morimoto's and Ikeda's healthy habits showed significant differences in the incidence between poor and moderate groups, and between poor and favorable groups. In males, a significant difference was observed among the poor, moderate and favorable groups for Ikeda's healthy habits. However, no significant difference was observed for Breslow's healthy practices. Morimoto's items only showed a significant difference between the poor and moderate groups. Conclusion Among the 3 models tested, Ikeda's healthy habits were the most useful for decreasing the risk of metabolic syndrome in Japanese.

著者

Yusuke Nakade Masaki Fujimura Noriyuki Ohkura Masako Nakata Yuko Nanbu Hiroyasu Oe Hiroshi Horita Yoshio Sakai Takashi Wada

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.52, no.18, pp.2017-2023, 2013 (Released:2013-09-15)

参考文献数

17

被引用文献数

1 4

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Objective Partial expiratory flow-volume curves have the potential to detect mild bronchoconstriction because they are not affected by the modulatory effects of deep inspiration. The aim of this study was to investigate the relationship between the efficacy of bronchodilator therapy (BDT) in treating the cough and to assess the increase in the expiratory flow of the partial flow-volume curve at 40% above the residual volume level (PEF40) caused by treatment with a short-acting beta-2 agonist (SABA) in patients with chronic nonproductive cough. Methods We measured the reversibility of PEF40 caused by a SABA in 42 patients with chronic nonproductive cough at visit 1 (day 0). The patients received BDT for six days. The visual analogue scale (VAS) was used to assess the efficacy of BDT in treating coughing at visit 2 (day 7) (0 mm, 'no cough;' 100 mm, 'no change in coughing'). Results Reversibility of the PEF40 was correlated (r=0.690, p<0.001) with the VAS score determined at visit 2 and was higher in the patients with cough variant asthma (CVA) (44.9±18.3%) than in those with atopic cough (13.4±10.4%) (p<0.01). Conclusion Reversibility of the PEF40 predicted the efficacy of BDT in patients with chronic nonproductive cough and helped to identify patients with CVA.

著者

Keiichiro Matsukura Mitsuru Okuda Kenji Kubota Takashi Wada

出版者

日本応用動物昆虫学会

雑誌

Applied Entomology and Zoology (ISSN:00036862)

巻号頁・発行日

vol.43, no.4, pp.535-540, 2008-11-25 (Released:2008-11-30)

参考文献数

15

被引用文献数

13 33 18

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Snails of the genus Pomacea in several regions of Japan showed genetic divergence. Phylogenetic analysis based on the mitochondrial cytochrome c oxidase subunit I gene segregated them into two major clades, one corresponding to P. insularum, the other to P. canaliculata. We developed a simple molecular method to distinguish between the two species to investigate their distribution in Japan. We identified P. canaliculata at all 16 sampling locations except Iriomote Isle, and P. insularum at four locations (Iwata, Fukuyama, Ishigaki Isle, and Iriomote Isle), supporting a previous report that P. canaliculata is the dominant species in Japan. Morphological comparison of the two species collected from the same habitat (Ishigaki Isle) revealed that most P. canaliculata had clear dark spiral bands on their shells, and that P. insularum had no or only faint spiral bands. However, it is difficult to distinguish the two species using only shell morphology.