著者

Katsuyuki MORISHITA Hiroshi KARASUNO Yuka YOKOI Kazunori MOROZUMI Hisayoshi OGIHARA Toshikazu ITO Takayuki FUJIWARA Tetsuya FUJIMOTO Koji ABE

出版者

日本理学療法士協会

雑誌

Journal of the Japanese Physical Therapy Association (ISSN:13441272)

巻号頁・発行日

vol.17, no.1, pp.1-7, 2014 (Released:2014-12-20)

参考文献数

32

被引用文献数

19

---

Purpose: This study aimed to clarify the effects of therapeutic ultrasound on intramuscular local blood circulation (and oxygen dynamics) using near-infrared spectroscopy (NIRS). Participants: The participants were 11 healthy males. Methods: All participants performed all three trials; (1) the ultrasound (US group), (2) without powered ultrasound (placebo group), and (3) rest (control group). Ultrasound was applied at 3 MHz, 1.0 W/cm2, and 100% duty cycle for 10 minutes. Evaluation index were oxygenated, deoxygenated, and total hemoglobin (Hb) concentrations in the intramuscular and skin surface temperature (SST). The experimental protocol was a total of 40 minutes, that is, 10 minutes before trial (rest), 10 minutes during the trial (ultrasound, placebo, and control), and 20 minutes after trial (rest). The NIRS and SST data collected before and after the trial were divided into 5 minutes intervals for further analysis. Results: Oxygenated and total hemoglobin levels were significantly higher in the US group than in the placebo and control groups for the 20 minutes after ultrasound ( p < 0.01). The SST was significantly higher in the US group than in the control for 15 minutes after ultrasound ( p < 0.05), while it was significantly lower in the placebo group than in the US and control groups for 20 minutes after the trials ( p < 0.01). Conclusion: The effects of ultrasound were maintained for 20 minutes after the trial on intramuscular blood circulation and oxygen dynamics. These effects were caused by a combination of thermal and mechanical effects of the ultrasound.

著者

Katsuyuki Morishita Hiroshi Karasuno Yuka Yokoi Kazunori Morozumi Hisayoshi Ogihara Toshikazu Ito Masaaki Hanaoka Takayuki Fujiwara Tetsuya Fujimoto Koji Abe

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.5, pp.711-715, 2014 (Released:2014-05-29)

参考文献数

23

被引用文献数

7 29

---

[Purpose] This study aimed to clarify the effects of therapeutic ultrasound on range of motion and stretch pain and the relationships between the effects. [Subjects] The subjects were 15 healthy males. [Methods] Subjects performed all three interventions: (1) ultrasound (US group), (2) without powered ultrasound (placebo group), and (3) rest (control group). Ultrasound was applied at 3 MHz with an intensity of 1.0 W/cm2 and a 100% duty cycle for 10 minutes. The evaluation indices were active and passive range of motion (ROM), stretch pain (visual analog scale; VAS), and skin surface temperature (SST). The experimental protocol lasted a total of 40 minutes; this was comprised of 10 minutes before the intervention, 10 minutes during the intervention (US, placebo, and control), and 20 minutes after the intervention. [Results] ROM and SST were significantly higher in the US group than in the placebo and control groups for the 20 minutes after ultrasound, though there was no change in stretch pain. [Conclusion] The effects of ultrasound on ROM and SST were maintained for 20 minutes after the intervention. The SST increased with ultrasound and decreased afterwards. Additionally, the SST tended to return to baseline levels within 20 minutes after ultrasound exposure. Therefore, these effects were caused by a combination of thermal and mechanical effects of the ultrasound.

著者

Lin Wei JONG Takayuki FUJIWARA Hisayoshi NOZAKI Shin-ya MIYAGISHIMA

出版者

The Japan Academy

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.93, no.10, pp.832-840, 2017-12-11 (Released:2017-12-11)

参考文献数

31

被引用文献数

7

---

Volvocine algae constitute a green algal lineage comprising unicellular Chlamydomonas, four-celled Tetrabaena, eight to 32-celled Gonium, and others up to Volvox spp., which consist of up to 50,000 cells. These algae proliferate by multiple fissions with cellular growth up to several fold in size and subsequent successive cell divisions. Chlamydomonas reinhardtii cells produce two to 32 daughter cells by one to five divisions, depending on cellular growth in the G1 phase. By contrast, in this study, we found that Tetrabaena socialis and Gonium pectorale cells mostly produced four and eight daughter cells by two and three successive divisions, respectively. In contrast to C. reinhardtii, which is committed to cell division when the cell has grown two-fold, T. socialis and G. pectorale are committed only when the cells have grown four- and eight-fold, respectively. Thus, our results suggest that evolutionary changes in cellular size for commitment largely contributes to the emergence and evolution of multicellularity in volvocine algae.

著者

Norifumi Takeda Hiroki Yagi Hironori Hara Takayuki Fujiwara Daishi Fujita Kan Nawata Ryo Inuzuka Yuki Taniguchi Mutsuo Harada Haruhiro Toko Hiroshi Akazawa Issei Komuro

出版者

一般社団法人 インターナショナル・ハート・ジャーナル刊行会

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.16-094, (Released:2016-05-13)

被引用文献数

1 50

---

Marfan syndrome (MFS) is an autosomal dominant heritable disorder of connective tissue that affects the cardiovascular, skeletal, ocular, pulmonary, and nervous systems and is usually caused by mutations in the FBN1 gene, which encodes fibrillin-1. MFS is traditionally considered to result from the structural weakness of connective tissue. However, recent investigations on molecular mechanisms indicate that increased transforming growth factor-β (TGF-β) activity plays a crucial role in the pathogenesis of MFS and related disorders, such as Loeys–Dietz syndrome (LDS), which is caused by mutation in TGF-β signaling-related genes. In addition, recent studies show that angiotensin II type 1 receptor (AT1R) signaling enhances cardiovascular pathologies in MFS, and the angiotensin II receptor blocker losartan has the potential to inhibit aortic aneurysm formation. However, the relationship between TGF-β and AT1R signaling pathways remains poorly characterized. In this review, we discuss the recent studies on the molecular mechanisms underlying cardiovascular manifestations of MFS and LDS and the ensuing strategies for management.

著者

Hiroshi Karasuno Kazunori Morozumi Takayuki Fujiwara Ah Cheng Goh Iwao Yamamoto Fujitoshi Senga

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.17, no.2, pp.71-79, 2005 (Released:2006-03-16)

参考文献数

36

被引用文献数

7 9

---

The purpose of this study was to determine the relationship between the changes in intramuscular blood volume (IMBV) under continuous shortwave diathermy (CSWD) and compare them with the electric hot pack (EHP). The subjects consisted of 41 healthy adults, who received one of three interventions: CSWD (n=17), EHP (n=12), or no intervention (Controls: n=12). Analyses were done of the values obtained five minutes preceding the intervention (T1), during the intervention (T2), and after the intervention (T3). CSWD was applied with an output of 80 W. Both CSWD and EHP were applied for 10 min. Changes in IMBV of the right medial gastrocnemius muscle were evaluated using near-infrared spectroscopy (NIRS). Oxy-hemoglobin (oxy-Hb), deoxy-hemoglobin (deoxy-Hb), and total-hemoglobin (total-Hb) were measured using NIRS. At T2 in the CSWD trial, the integration values of oxy-Hb and total-Hb were significantly increased compared with those of the controls (p<0.01), and they were significantly increased compared with those of both the controls and the EHP trial (p<0.01) at T3 of the CSWD trial. The study results verified that IMBV increases as a result of the local thermal effect of CSWD, and also suggest that CSWD is more effective at enhancing IMBV than EHP.