- 著者
- TSUNEHIRO ISHIDA NORITAKA SUGAMATA YOSHIKI TAKAI JUN HORIGUCHI YUKIKO KOIBUCHI TAKAO YOKOE YUICHI IINO YASUO MORISHITA TETSUNARI OYAMA TAKASHI JOSHITA
- 出版者
- The Kitakanto Medical Society
- 雑誌
- The KITAKANTO Medical Journal (ISSN:00231908)
- 巻号頁・発行日
- vol.43, no.5, pp.519-524, 1993-09-01 (Released:2009-10-21)
- 参考文献数
- 16
甲状腺癌術前診断における穿刺吸引細胞診の有用性を検討した.1975年から1992年間に穿刺吸引細胞診を施行し, 病理組織診断が判明した結節性甲状腺腫1,540例 (甲状腺癌580例, 良性腫瘍943例, 橋本病17例) を対象とした.穿刺吸引細胞診の診断能は, sensitivity 85%, specificity 93%, accuracy 90%であった.甲状腺癌では乳頭癌の正診率が90%と高く, 濾胞癌で60%と不良であった.1.0cm以下以下の微小癌にも高い正診率 (89%) が得られた.良性腫瘍の正診率は高いが, 橋本病で偽陽性が多くみられた.甲状腺癌の各種診断法の正診率を比較すると, 穿刺吸引細胞診は触診法や超音波検査に比べ良好な成績であった.以上, 穿刺吸引細胞診は甲状腺結節の良悪性診断のみならず, 組織型の推定, 微小癌の診断に有用かつ信頼度が高く, 初診時の必須検査法とすべきである.
- 著者
- Nami Takada Mitsuyoshi Hirokawa Chiho Ohbayashi Takeshi Nishikawa Tomoo Itoh Naoko Imagawa Tetsunari Oyama Tadashi Handa Tadashi Hasegawa Shintaro Sugita Akiko Murata Akira Miyauchi
- 出版者
- The Japan Endocrine Society
- 雑誌
- Endocrine Journal (ISSN:09188959)
- 巻号頁・発行日
- vol.65, no.2, pp.239-244, 2018 (Released:2018-02-26)
- 参考文献数
- 14
- 被引用文献数
- 6 18
Hyalinizing trabecular tumour (HTT) immunohistochemically shows cell membranous immunoreactivity for MIB-1. This aberrant immunoreactivity is an important factor for the diagnosis of HTT. However, fully automated stainers frequently fail to confirm the immunoreactivity. The aim of this study is to investigate the cause of false negative cell membranous immunoreactivity for MIB-1 in HTT using fully automated stainers, to determine potential reasons for the problem, and to establish methods confirming cell membranous immunoreactivity for MIB-1 in HTT. Six participating institutions examined immunoreactivity for MIB-1 in 10 HTT cases using two approaches: fully automated and semi-automated methods. In the latter, antigen retrieval was carried out using manual methods adopted for routine assays at each institute. The autostainers used included the BOND-MAX, BOND-III, Benchmark XT, and Omnis systems. Using fully automated methods, institute E showed cell membranous MIB-1 positivity in all HTT cases. In contrast, at institute D, all HTT cases were negative. The positive rates of the remaining four institutes ranged from 10% to 20%. The incidence of positive cases using semi-automated methods was 100%, 90%, 90%, 30%, 80%, and 100% at institutes A, B, C, D, E, and F, respectively. We assert that antigen retrieval should be conducted manually for diagnosis of HTT; furthermore, definitively diagnosed HTT should be prepared as the external positive control.