- 著者
- Kana Yazaki Ken Takahashi Sachie Shigemitsu Mariko Yamada Takeshi Iso Maki Kobayashi Katsumi Akimoto Hiroyuki Tamaichi Junya Fujimura Masahiro Saito Masaki Nii Toshiaki Shimizu
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-17-0874, (Released:2017-11-29)
- 参考文献数
- 35
- 被引用文献数
- 20
Background:Anthracycline cardiotoxicity affects clinical outcomes, and its early detection using methods that rely on conventional echocardiography, such as left ventricular ejection fraction (LVEF) is difficult. This study aimed to evaluate the characteristics and the differences in cardiac dysfunction among childhood cancer survivors in 3 age groups using layer-specific strain analysis in a wide age range.
- 著者
- YUKA HONDA MITSUYOSHI SUZUKI YUICHI SATO KEIJI KURODA HIROMICHI SHOJI TOSHIAKI SHIMIZU
- 出版者
- The Juntendo Medical Society
- 雑誌
- 順天堂醫事雑誌 (ISSN:21879737)
- 巻号頁・発行日
- vol.62, no.2, pp.153-159, 2016 (Released:2016-07-02)
- 参考文献数
- 30
- 被引用文献数
- 1
Objective: The aim of this study was to investigate the associations of anti-Müllerian hormone (AMH) levels with physique and 25-hydroxyvitamin D (25OH-D) levels in healthy women of reproductive age based on measurements of nutritional status and physical constitution.Materials and Methods: Subjects comprised 108 non-obese women (age range, 21-39 years) who underwent examination of their physique, blood biochemistry and nutritional state. For data analysis, subjects were first divided by age. AMH levels were grouped by serum 25OH-D concentration using Holick’s classification: deficiency, <30 ng/ml; and sufficiency, ≥30 ng/ml.Results: Mean levels were 25.2±8.4 ng/ml for serum 25OH-D and 4.9±2.4 ng/ml for AMH. Overall, 76 women (70.4%) were diagnosed with 25OH-D deficiency. Serum AMH levels were significantly lower in subjects with 25OH-D deficiency (4.5±2.5 ng/ml) than in those with 25OH-D sufficiency (5.7±1.9 ng/ml; p<0.01). Significant differences were seen in the frequency of subjects with 25OH-D deficiency and sufficiency between low AMH (<2.2 ng/ml) status and normal AMH (≥2.2 ng/ml)(16/17 [94.1%] vs. 1/17 [5.9%] for low AMH status; 60/91 [65.9%] vs.31/91 [34.1%] for normal AMH status, respectively; p<0.05). Independent predictors of serum AMH levels≥2.2 ng/ml were serum 25OH-D level (p<0.05) and age (p<0.05) according to binary logistic regression analysis.Conclusions: Decreased serum AMH level is associated with vitamin D deficiency, but is unrelated to physique state in this population.