著者

Yukako Nakagami Genichi Sugihara Kengo Uemura Naoto Jingami Keita Ueda Ryosuke Takahashi Toshiya Murai

出版者

日本てんかん学会

雑誌

Epilepsy & Seizure (ISSN:18825567)

巻号頁・発行日

vol.7, no.1, pp.23-29, 2014 (Released:2014-02-15)

参考文献数

14

被引用文献数

1

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Cerebral microbleeds (CMBs) usually produce no symptoms. We encountered a patient who developed cognitive decline and psychotic symptoms associated with nonconvulsive status epilepticus (NCSE), with presumptive epileptogenic focus possibly caused by a CMB. A 70-year-old man developed progressive cognitive disturbances including disorientation and hallucinations two months after a mild head injury. He was admitted to our hospital three months after the trauma, because of progression of symptoms. The first positron emission tomography (PET) with [18F]fluoro-2-deoxy-d-glucose (FDG) demonstrated intense FDG uptake in the left occipitoparietal region, in which a CMB was detected by T2∗-weighted magnetic resonance imaging (MRI). Electroencephalography showed continuous slow waves in the left occipital and parietal areas. After anticonvulsive therapy, his symptoms completely disappeared, accompanied by change in FDG uptake. Our case suggests that CMBs may be an epileptogenic focus of NCSE, and that FDG-PET is useful for the diagnosis of NCSE and assessment of therapeutic efficacy.

著者

Takayuki KIKUCHI Yasushi TAKAGI Jyoji NAKAGAWARA Tsukasa UENO Shiho UBUKATA Kiyohiro HOUKIN Yoshio ARAKI Jun C TAKAHASHI Hiroyuki NAKASE Toshiya MURAI Susumu MIYAMOTO COSMO-Japan Study Group

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2023-0041, (Released:2023-05-11)

参考文献数

24

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Cognitive impairment in adult patients with moyamoya disease (MMD) is sometimes overlooked and can occur in patients with no ischemic or hemorrhagic lesions. Better profiling and reliable diagnostic methods that characterize the group and associate the impairments and pathology of MMD are required in order to deliver appropriate treatments and support. The potential of 123I-iomazenil single-photon emission computed tomography (SPECT) for this issue has been reported in some studies, but the universality of this method remains unclear. A multicenter study of adult patients (aged 18-60 years) with MMD who experienced difficulties in social lives despite normal activities of daily living was implemented to delineate the common characteristics of this group of patients. In this study, iomazenil SPECT, besides patient characteristics, cognitive functions, and conventional imaging, was acquired to examine whether this method is suitable as a universal diagnostic tool. A total of 36 patients from 12 institutes in Japan were included in this study. Domain scores of world health organization quality of life 26 indicated low self-rating in physical health and psychological domains. The percentages of patients who had <85 in each index were 27.8%-33.3% in the WAIS-III and 16.7%-47.2% in the Wechsler Memory Scale-Revised. The group analysis of iomazenil SPECT demonstrated a decreased accumulation in the bilateral medial frontal areas in comparison with the normal control, whereas there were no specific characteristics on conventional imaging in the cohort. Iomazenil SPECT is a possible universal diagnostic method for the extraction of patients with cognitive impairment in MMD.

著者

Takuya Ishino Akiko Kamesaka Toshiya Murai Masao Ogaki

出版者

Association of Behavioral Economics and Finance

雑誌

行動経済学 (ISSN:21853568)

巻号頁・発行日

vol.5, pp.269-272, 2012 (Released:2013-06-12)

参考文献数

1

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Using large panel data which consist of responses from over 4000 households in all over Japan, we analyze changes in people's worldviews and subjective well-being (happiness) before and after the Great East Japan Earthquake. As a result we find that 1) there were more people—more than six times as many—who replied that their happiness improved after the earthquake than those who said it worsened, and also that 2) many more Japanese people have become more altruistic since the earthquake, even in the most affected areas. One possible interpretation of these results is that many Japanese became more altruistic as a result of the Great East Japan Earthquake, made donation, and donating improved people's happiness. Our regression analysis that allows for reverse causality yields results that are consistent with this interpretation.