著者
Kohei Takata Satoshi Imaizumi Emi Kawachi Yasunori Suematsu Tomohiko Shimizu Satomi Abe Yoshino Matsuo Hitomi Tsukahara Keita Noda Eiji Yahiro Bo Zhang Yoshinari Uehara Shin-ichiro Miura Keijiro Saku
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-14-0638, (Released:2014-10-16)
参考文献数
47
被引用文献数
8 47

Background:Smoking cessation reduces the risk of cardiovascular disease (CVD) and improves clinical outcomes in public health. We studied the effect of smoking cessation on high-density lipoprotein (HDL) functionality.Methods and Results:We randomly treated 32 smokers with varenicline or a transdermal nicotine patch as part of a 12-week smoking cessation program (The VN-SEESAW Study). The plasma lipid profiles, plasma and HDL malondialdehyde (MDA) levels, HDL subfractions as analyzed by capillary isotachophoresis, cholesterol efflux capacity, and antiinflammatory activity of HDL were measured before and after the anti-smoking intervention. After smoking cessation, HDL-C, apoA-I levels and HDL subfractions were not significantly different from the respective baseline values. However, cholesterol efflux capacity and the HDL inflammatory index (HII) were significantly improved after smoking cessation. The changes in both parameters (%∆ cholesterol efflux capacity and ∆HII) were also significantly improved in the successful smoking cessation group compared with the unsuccessful group. The changes in cholesterol efflux capacity and HII also correlated with those in end-expiratory CO concentration and MDA in HDL, respectively.Conclusions:Our findings indicate that smoking cessation leads to improved HDL functionality, increased cholesterol efflux capacity and decreased HII, without changing HDL-C or apoA-I levels or HDL subfractions. This may be one of the mechanisms by which smoking cessation improves the risk of CVD.
著者
Yukiya Tanoue Takaaki Komiyama Hiroaki Tanaka Yasuki Higaki Yoshinari Uehara
出版者
The Japanese Society of Physical Fitness and Sports Medicine
雑誌
The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
巻号頁・発行日
vol.10, no.4, pp.181-189, 2021-07-25 (Released:2021-07-15)
参考文献数
35

After exercise training, improvement in cognitive function is associated with high parasympathetic nervous activity. However, the relationship between cardiac autonomic nervous activity and cognitive function after acute exercise may differ from that after chronic exercise, because parasympathetic nervous activity decreases with acute exercise. Here, we examined the relationship between parasympathetic nervous activity and cognitive function after acute exercise. Twelve male participants performed cognitive tasks in exercise and non-exercise conditions, with a randomized crossover design. Participants in the exercise condition ran on a treadmill for 10 min, with a running speed corresponding to a rate of perceived exertion (RPE) of 10–12 in each subject. Cognitive tasks were performed before and after both conditions. Heart rate variability during cognitive tasks was measured to evaluate autonomic nervous system activity. In the exercise condition, RPE was 11.1 ± 0.2 (mean ± SE) immediately after exercise. Exercise at RPE 10–12 improved reaction times in Go trials (from 687.8 ± 55.2 to 568.2 ± 45.9 ms, P < 0.05). In the non-exercise condition, cognitive performance remained stable throughout the experiment. In addition, parasympathetic nervous activity (high-frequency component of heart rate variability) remained low after exercise compared with before exercise (from 586.4 ± 122.5 to 372.8 ± 92.9 ms2, P < 0.05). In contrast, parasympathetic nervous activity increased in the non-exercise condition (from 516.6 ± 94.9 ms2 to 642.5 ± 85.6 ms2, P < 0.05). The present results suggest that improvement in cognitive function after acute exercise may be related to reduced parasympathetic nervous activity.
著者
Kohei Takata Satoshi Imaizumi Emi Kawachi Yasunori Suematsu Tomohiko Shimizu Satomi Abe Yoshino Matsuo Hitomi Tsukahara Keita Noda Eiji Yahiro Bo Zhang Yoshinari Uehara Shin-ichiro Miura Keijiro Saku
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.78, no.12, pp.2955-2962, 2014-11-25 (Released:2014-11-25)
参考文献数
47
被引用文献数
23 47

Background:Smoking cessation reduces the risk of cardiovascular disease (CVD) and improves clinical outcomes in public health. We studied the effect of smoking cessation on high-density lipoprotein (HDL) functionality.Methods and Results:We randomly treated 32 smokers with varenicline or a transdermal nicotine patch as part of a 12-week smoking cessation program (The VN-SEESAW Study). The plasma lipid profiles, plasma and HDL malondialdehyde (MDA) levels, HDL subfractions as analyzed by capillary isotachophoresis, cholesterol efflux capacity, and antiinflammatory activity of HDL were measured before and after the anti-smoking intervention. After smoking cessation, HDL-C, apoA-I levels and HDL subfractions were not significantly different from the respective baseline values. However, cholesterol efflux capacity and the HDL inflammatory index (HII) were significantly improved after smoking cessation. The changes in both parameters (%∆ cholesterol efflux capacity and ∆HII) were also significantly improved in the successful smoking cessation group compared with the unsuccessful group. The changes in cholesterol efflux capacity and HII also correlated with those in end-expiratory CO concentration and MDA in HDL, respectively.Conclusions:Our findings indicate that smoking cessation leads to improved HDL functionality, increased cholesterol efflux capacity and decreased HII, without changing HDL-C or apoA-I levels or HDL subfractions. This may be one of the mechanisms by which smoking cessation improves the risk of CVD. (Circ J 2014; 78: 2955–2962)