著者
Takahashi Kazutoshi Tanabe Koji Ohnuki Mari Narita Megumi Ichisaka Tomoko Tomoda Kiichiro Yamanaka Shinya
出版者
Elsevier B.V.
雑誌
Cell (ISSN:00928674)
巻号頁・発行日
vol.131, no.5, pp.861-872, 2007-11-30

Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Human iPS cells were similar to human embryonic stem (ES) cells in morphology, proliferation, surface antigens, gene expression, epigenetic status of pluripotent cell-specific genes, and telomerase activity. Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts.

言及状況

外部データベース (DOI)

CiteULike (24 posts)

[adult][aged][animals][biological][cardiac][cell][cells][cultured][differentiation][dna-binding][embryo][factor-3][factors][female][fibroblasts][genes][genetic][genetics][genetics-metabolism][hmgb][humans][icr][inbred][kruppel-like][male][mammalian][markers][metabolism][metabolism-physiology][mice][myc][myocytes][neurons][nuclear][octamer][pathology][physiology][pluripotent][proteins][reprogramming][soxb1][stem][telomerase][teratoma][transcription][transduction]
[1-8-31][alt][ips][jdc]
[cell-differentiation][dissertation]
[human_fibroblasts][ipsc][pluripotent_stem_cells][stem_cells]
[adult][aged][animals][biological][cardiac][cell][cells][cultured][differentiation][dna-binding][embryo][factor-3][factors][female][fibroblasts][genes][genetic][hmgb][humans][icr][inbred][kruppel-like][male][mammalian][markers][mice][myc][myocytes][neurons][nuclear][octamer][pluripotent][proteins][reprogramming][stem][telomerase][teratoma][transcription][transduction]
[barcode][fbl][klf][myc][riken]
[molecular-general][molecular-signaling][morphogenesis][physiological-remodeling][regeneration][stem-cells]

はてなブックマーク (1 users, 1 posts)

[図書館情報学][図書館][司書資格] ips細胞について

Twitter (17 users, 18 posts, 9 favorites)

ips / “Kyoto University Research Information Repository: Induction of Pluripotent Stem Cells from Adult Human Fibrobl…” http://t.co/BGqZxDTa
京大図書館が公開してた。http://t.co/gMirKEnx
【祝・山中先生ノーベル賞受賞記念】京都大学では山中伸弥先生のiPS論文の原稿を公開しています。こちらからご覧ください。 http://t.co/DsUXEGIF
IR(著者版)もOA(出版社版)もどっちも価値あり。 RT @sabarya: ヒトiPS細胞の樹立に成功した2007年の論文はKURENAIに掲載。 http://t.co/nYy527S0 Cellのサイトでも読めます。 http://t.co/aXU5rA2t
ヒトiPS細胞の樹立に成功した2007年の論文はKURENAIに掲載。 http://t.co/QlVcXdV8 Cellのサイトでも読めます。 http://t.co/NXKMnUWk
The historic research on the making of human generation without sexual copulation. http://t.co/yKtpqmJ8
芹ケ野はこれにしよ http://t.co/3Jiw53Sx
KURENAIは、昨日京都市民栄誉賞を受賞された山中伸弥先生の論文も収録してますよ!たとえばこれ→ http://hdl.handle.net/2433/49782 [S]

収集済み URL リスト