著者

Steffen Mickenautsch

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.59, no.2, pp.263-272, 2017 (Released:2017-06-22)

参考文献数

27

被引用文献数

3

---

Fissure sealant retention is traditionally considered as a proxy measure for caries prevention. This study investigated the logic behind this proposition, and its validity. A logical framework of the proposition was established. The mechanism of caries development was transferred into a Directed acyclic graph, and this was used to investigate the logical framework. The sensitivity and specificity of full sealant retention in the prediction of dental carious lesion development and the number of false positive/false negative prediction rates were computed. The sensitivity/specificity was statistically compared to that of random values. A contradiction in the logical framework was identified. The mean sensitivity/specificity was 37.9% (SD = 27.8%) and 67.6% (SD = 28.4%), respectively. When these values were compared against random values (30.5%, SD = 25.7% and 58.7%, SD = 31.6%), a non-significant sensitivity (P = 0.06) and a borderline higher specificity (P = 0.04) were observed. The overall false prediction rate was 33.7%, with 16.9% and 16.8% false negative and false positive predictions, respectively. The sensitivity/specificity was too low and the false prediction rate was too high to consider retention a valid proxy for caries prevention. The logic behind the investigated proposition is flawed, contradicted by the current empirical evidence, and thus invalid.

著者

Masao Araki Shunsuke Namaki Toshihiko Amemiya Kunihito Matsumoto Kazuya Honda Yoshiyuki Yonehara Naoyuki Matsumoto Masatake Asano

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.4, pp.533-537, 2016 (Released:2016-12-23)

参考文献数

32

被引用文献数

3

---

The occurrence of ameloblastic fibro-odontoma (AFO) in the oral region is unusual and accounts for 1-3% of all odontogenic tumors. AFO presents mixed radiopaque patterns within the lesion with diverse findings; therefore, it is important to compare this tumor with other odontogenic tumors that radiographically present with calcified bodies. Herein, we observed the calcification patterns within the lesion in seven AFO cases (five males, two females; mean age, 8.3 years; age range, 4-13 years). Periapical and panoramic radiographs were obtained from all seven cases. Five cases underwent conventional computed tomography (CT) scanning, and one underwent cone beam CT. Classification of the calcifications primarily involved the following two characteristics on the X-rays: appearance and location of the lesions. All seven cases were located in the molar regions of the mandible in association with impacted teeth. The calcification patterns of these AFOs were mixed or inhomogeneous within the lesion with various findings, including complex odontoma-like calcifications. However, the patterns differed between panoramic radiography and CT in some cases. The radiolucent lesions in AFO demonstrated varying calcification patterns and were associated with impacted teeth on the CT images.(J Oral Sci 58, 533-537, 2016)

著者

Norbert Pásztor Krisztina Kárpáti János Szöllősi Márk Keresztúri Zoltan Kozinszky István Gorzó Márta Radnai

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.2, pp.247-253, 2016 (Released:2016-06-25)

参考文献数

44

被引用文献数

5

---

About 30% of male infertility cases are idiopathic. Previous studies reported a positive correlation between deep periodontal pockets and sperm sub-motility, which suggests that periodontitis might have a role in idiopathic semen abnormality pathospermia. We evaluated correlations between periodontal infection parameters and the results of sperm analysis of men with idiopathic infertility. In this observational study, semen quality and periodontal status were analyzed for 95 otherwise healthy men attending an andrology unit for sperm analysis. Half the men in the sperm pathology and normozoospermia groups (50.8% and 50%, respectively) had poor periodontal status. Among the 95 participants, 38% had oligozoospermia, 28% had asthenozoospermia, 16% had cryptozoospermia, and 15% were classified as normozoospermic. Sperm pathology category was not associated with frequency of deep periodontal pockets or calculus. Bleeding on probing was significantly lower among men with asthenozoospermia than among those with normozoospermia. Poor periodontal status was not associated with any sperm pathology category or parameter. In contrast with previous findings, the present results indicate that pathospermia and poor semen quality are not associated with periodontal infection in men with idiopathic infertility. (J Oral Sci 58, 247-253, 2016)

著者

Dagli Rushabh J. Tadakamadla Santhosh Dhanni Chandrakant Duraiswamy Prabu Kulkarni Suhas

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.50, no.3, pp.267-272, 2008

被引用文献数

1 36

---

The aim of the present study was to evaluate the oral health attitudes and behavior of undergraduate dental students in India according to age, sex and level of dental education, and to compare it with those of other countries with different socioeconomic conditions. A self-administered questionnaire based on the Hiroshima University – Dental Behavior Inventory (HU-DBI) was distributed among 372 dental students at Darshan Dental College and Hospital (DDCH). The response rate was 75.8% with 44% males and 56% females. The mean HU-DBI score showed a significant relationship (<I>P</I> < 0.05) with age by one way-analysis of variance (ANOVA). The students were considerably concerned about the appearance of their teeth and gums and halitosis. The total mean score was not markedly higher in the clinical years (years 3 and 4) than in the non-clinical years (years 1 and 2), indicating that the students were almost equally aware. Although there were no statistically significant differences in gender and academic year for the mean score of HU-DBI, the present study showed that dental students in India generally had poorer oral health awareness compared to several other countries. The oral health behavior of Indian dental students has to be improved in order to serve as a positive model for their patients, family, and friends. (J. Oral Sci. 50, 267-272, 2008)

著者

Taiichi Kitano Yoshikazu Mikami Takashi Iwase Masatake Asano Kazuo Komiyama

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.2, pp.163-169, 2016 (Released:2016-06-25)

参考文献数

24

被引用文献数

10

---

Porphyromonas gingivalis is important in the development of marginal periodontitis. However, the precise role and localization of P. gingivalis in chronic periapical periodontitis remain unclear. Thus, methods that can detect P. gingivalis in formalin-fixed and paraffin-embedded (FFPE) tissue samples are needed. We assessed a technique combining loop-mediated isothermal amplification (LAMP) with PCR (PCR-LAMP) for detection of P. gingivalis, using 110 FFPE tissue samples of chronic apical periodontitis. PCR-LAMP specifically detected P. gingivalis with high sensitivity in FFPE tissue samples, and the sensitivity of the technique was higher than that of PCR or LAMP alone. The results of immunohistochemistry (IHC) confirmed the specificity of PCR-LAMP. IHC showed that P. gingivalis was localized in a granular layer of chronic apical periodontitis, a region that correlated with the localization of macrophages. This is the first study to describe the localization of P. gingivalis in human periapical periodontitis. In conclusion, PCR-LAMP was an effective tool for detecting P. gingivalis in periapical periodontitis. In addition, IHC results improve our understanding of the role of P. gingivalis in the progression of periapical periodontitis. (J Oral Sci 58, 163-169, 2016)

著者

Naoto Yoshinuma Ryosuke Koshi Kazuhiro Kawamoto Masataka Idesawa Naoyuki Sugano Shuichi Sato

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.1, pp.137-140, 2016 (Released:2016-03-26)

参考文献数

10

被引用文献数

3

---

This case report describes the clinical efficacy of treatment with basic fibroblast growth factor (FGF-2) for periodontal regeneration. A patient with aggressive periodontitis participated in a clinical trial involving administration of 0.3% FGF-2 in comparison with a placebo control. To evaluate the efficacy of FGF-2, standardized radiographs were taken before surgery and at 12, 24, and 36 weeks after FGF-2 treatment. The rate of increase in alveolar bone height was 86.9% at 36 weeks. The 6-year postoperative radiograph showed significant development of alveolar bone in comparison with the first visit. FGF-2 treatment may be effective for periodontal regeneration in cases of aggressive periodontitis. (J Oral Sci 58, 137-140, 2016)

著者

Osamu Saiki Hiroyasu Koizumi Nobutaka Akazawa Akihisa Kodaira Kentaro Okamura Hideo Matsumura

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.1, pp.117-123, 2016 (Released:2016-03-26)

参考文献数

20

被引用文献数

10

---

This study compared the wear characteristics of a heat-pressed lithium disilicate ceramic material opposed to feldspathic porcelain, a lithium disilicate glass ceramic, and zirconia materials. Ceramic plate specimens were prepared from feldspathic porcelain (EX-3 nA1B), lithium disilicate glass ceramics (e.max CAD MO1/C14), and zirconia (Katana KT 10) and then ground or polished. Rounded rod specimens were fabricated from heat-pressed lithium disilicate glass ceramic (e.max press LT A3) and then glazed or polished. A sliding wear testing apparatus was used for wear testing. Wear of glazed rods was greater than that of polished rods when they were abraded with ground zirconia, ground porcelain, polished porcelain, or polished lithium disilicate ceramics. For both glazed and polished rods, wear was greater when the rods were abraded with ground plates. The findings indicate that application of a polished surface rather than a glazed surface is recommended for single restorations made of heat-pressed lithium disilicate material. In addition, care must be taken when polishing opposing materials, especially those used in occlusal contact areas. (J Oral Sci 58, 117-123, 2016)

著者

Kunihiko Sawada Dirk Schulze Kunihito Matsumoto Shigenori Hirai Koji Hashimoto Kazuya Honda

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.57, no.4, pp.389-392, 2015 (Released:2015-12-13)

参考文献数

8

被引用文献数

8

---

We describe a rare case of osteochondroma of the coronoid process of mandible accompanied by severe trismus in a 14-year-old Japanese boy. The patient had initially been diagnosed as having internal derangement of the temporomandibular joint (TMJ), and conservative treatment had failed to improve the symptoms. Despite extremely limited TMJ movement, panoramic radiography revealed no abnormality, but magnetic resonance imaging suggested internal derangement of the left TMJ. Five months later, the trismus worsened and computed tomography revealed a bone-like mass confluent with the coronoid process, which was finally diagnosed as osteochondroma. The patient then underwent intra-oral coronoidectomy. (J Oral Sci 57, 389-392, 2015)

著者

Masao Araki Takeshi Kiyosaki Mai Sato Kiyomi Kohinata Kunihito Matsumoto Kazuya Honda

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.57, no.4, pp.373-378, 2015 (Released:2015-12-13)

参考文献数

43

被引用文献数

5

---

We measured the gonial angle (GA) on panoramic radiography (PR) and analyzed the correlation between the GA on PR and lateral cephalometric radiography (LCR). In total, 49 PR films and LCR films from dentate young adults were evaluated. Orthodontists plotted four points (articulare, menton, posterior gonion, and lower gonion) on the PR and carefully traced them. Using a protractor, two radiologists measured the GA on LCR images. A simultaneous experimental study of two dry skulls was performed to compare the GA on LCR and PR. The GA was slightly smaller on the PR of the dry mandible than on the LCR and tended to decrease continuously with magnitude toward the Frankfort horizontal plane. The mean GA was 115.1 ± 5.2° on PR and 122.2 ± 6.4° on the LCR. The values were highly correlated (Pearson product-moment correlation coefficient, 0.801). The GA on PR was nonsignificantly smaller than that measured on LCR. The difference may be due to head position, the inclination angle of the mandibular body, and/or the direction of the incident X-ray beam. (J Oral Sci 57, 373-378, 2015)

著者

Kunihito Matsumoto Souksavanh Vongsa Ichiro Nakajima Ken-ichiro Ejima Kiyomi Kohinata Toshihiro Suzuki Shigeharu Hosono Hirofumi Aboshi Fumiyuki Kuwata Kichibee Otsuka

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.57, no.3, pp.235-239, 2015 (Released:2015-09-15)

参考文献数

12

被引用文献数

2 4

---

As part of quality assessment of a teleradiology program we evaluated the validity of patient information received, the quality of panoramic radiography imaging in Laos, and the ability of a Laotian radiologist to detect temporomandibular joint abnormalities. The amount of patient information gathered from 2,021 scans of panoramic radiographs was evaluated by triage before image diagnosis. Among the radiographs from 2,021 patients, primary triage indicated that there was insufficient information for 794 (39.3%) patients. Secondary triage to assess imaging failure included 1,227 radiographs, four of which were excluded from imaging diagnosis because of unacceptable image flaws. In total, 2,446 joints from 1,223 radiographs were evaluated for temporomandibular joint abnormalities in order to compare the image interpretation abilities of Laotian and Japanese radiologists. The kappa coefficient was 0.836 (P < 0.01) for the agreement between the two observers in detecting temporomandibular joint abnormalities on radiographs. We conclude that additional efforts are needed in order to overcome the challenges of maintaining quality in imaging techniques and diagnoses in Laos. (J Oral Sci 57, 235-239, 2015)

著者

Tamotsu Tsurumachi Yoriyuki Hirano Akiko Hira Yasuyo Aida Bunnai Ogiso

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.57, no.2, pp.157-160, 2015 (Released:2015-06-10)

参考文献数

10

被引用文献数

7

---

When a primary tooth sustains a traumatic injury, development of the permanent tooth can be disturbed, leading to various malformations. This case report details the 7-year follow-up of a developmental anomaly of a central mandibular incisor in a 10-year-old Japanese girl with a history of dental trauma that had occurred at age 4. The trauma had resulted in unusual crown dilaceration in the permanent successor, which exhibited a discoloured and abnormal crown morphology. Radiographic examination revealed crown dilaceration of the tooth, which had a curved root canal. (J Oral Sci 57, 157-160, 2015)

著者

Katsuyoshi Tsunori

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.57, no.2, pp.131-136, 2015 (Released:2015-06-10)

参考文献数

16

被引用文献数

1 11

---

This study investigated the effects of administration of parathyroid hormone (PTH) at different dosages and schedules on bone regeneration in critical-size bone defects in rat calvariae. After calvarial defects had been prepared in 50 rats, they were divided into five treatment groups: 15 µg/kg PTH daily (PTH-15), 35 µg/kg PTH three times per week (PTH-35), 105 µg/kg once per week (PTH-105-1), 105 µg/kg three times per week (PTH-105-3), and controls given vehicle alone. Bone regeneration was evaluated radiographically using micro-computed tomography (micro-CT) or histologically. The amount of newly generated bone in the calvarial defects was found to be significantly greater in the PTH groups than in the control group, and did not differ significantly among the PTH-15, PTH-35, and PTH-105-1 groups, whereas the PTH-105-3 group showed a significantly greater degree of new bone formation than the other PTH groups. It appeared that a higher dose of PTH stimulated a greater degree of bone regeneration in this experimental setting. The present results also suggest that the total dose of PTH administered is significantly related to the amount of bone regenerated within a defined period, indicating that less frequent administration of PTH might be a feasible protocol for bone regeneration therapy. (J Oral Sci 57, 131-136, 2015)

著者

Hiroyasu Kurokawa Toshiki Takamizawa Akitomo Rikuta Keishi Tsubota Masashi Miyazaki

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.57, no.2, pp.101-108, 2015 (Released:2015-06-10)

参考文献数

35

被引用文献数

3 14

---

In this clinical study, we evaluated the 3-year clinical performance of a resin composite containing a surface-prereacted glass ionomer (S-PRG) filler (Beautifil II; Shofu Inc., Kyoto, Japan) placed with a single-step self-etch adhesive (BeautiBond; Shofu Inc.) in posterior restorations. Using modified US Public Health Service criteria, two experienced investigators performed clinical evaluations at the baseline, 6 months, 18 months, and 3 years. Color match, marginal adaptation, anatomical form, surface roughness, marginal discoloration, postoperative sensitivity, and secondary caries were evaluated. After 3 years, 26 patients attended the recall and 31 restorations were evaluated. No postoperative sensitivity or secondary caries was observed at any time point, and no restorations failed during the follow-up period. However, surface roughness, marginal adaptation, and marginal discoloration showed deterioration after 3 years. In conclusion, although some clinical changes were observed, resin composite containing S-PRG filler placed with self-etch adhesive exhibited acceptable clinical behavior in posterior restorations. (J Oral Sci 57, 101-108, 2015)

著者

Jorge A. Jaramillo Jairo H. Ternera Pulido Jaime A. Castro Núñez William F. Bird Takashi Komabayashi

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.52, no.1, pp.137-143, 2010 (Released:2010-03-26)

参考文献数

18

被引用文献数

3 9

---

This article describes Colombia's development of formal dentistry, its dental school system, curriculum, and dental licensure, and current issues in oral health care. In 1969, there were only 4 dental schools in Colombia; at this writing there are 21. Five dental schools are public and the other 16 are private. Nearly all classes are conducted in Spanish. Undergraduate pre-dental coursework is not a prerequisite for dental school in Colombia. To obtain licensure, Colombian dental students must complete 5 years of study in dental school, earn a diploma, and work for the government for 1 year. There are approximately 41,400 dentists in Colombia, and the number is increasing quickly. However, the unemployment rate among dentists is very high, even though graduation from dental school is extremely difficult. Although the 1,100:1 ratio of citizens to dentists is considered satisfactory, access to dental care is limited due to the high rate of poverty. (J Oral Sci 52, 137-143, 2010)

著者

Mohammadmehdi Fani Jamshid Kohanteb

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.54, no.1, pp.15-21, 2012 (Released:2012-03-30)

参考文献数

37

被引用文献数

16 89

---

Aloe vera is a medicinal plant with anti-inflammatory, antimicrobial, antidiabetic and immune-boosting properties. In the present study we investigated the inhibitory activities of Aloe vera gel on some cariogenic (Streptococcus mutans), periodontopathic (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis) and an opportunistic periodontopathogen (Bacteroides fragilis) isolated from patients with dental caries and periodontal diseases. Twenty isolates of each of these bacteria were investigated for their sensitivity to Aloe vera gel using the disk diffusion and microdilution methods. S. mutans was the species most sensitive to Aloe vera gel with a MIC of 12.5 μg/ml, while A. actinomycetemcomitans, P. gingivalis, and B. fragilis were less sensitive, with a MIC of 25-50 μg/ml (P < 0.01). Based on our present findings it is concluded that Aloe vera gel at optimum concentration could be used as an antiseptic for prevention of dental caries and periodontal diseases. (J Oral Sci 54, 15-21, 2012)

著者

Nasrollah Saghravanian Nooshin Mohtasham Hamid Jafarzadeh

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.51, no.4, pp.509-514, 2009 (Released:2009-12-22)

参考文献数

17

被引用文献数

8 14

---

Adenoid cystic carcinoma (AdCC) and polymorphous low-grade adenocarcinoma (PLGA) have several common histological and clinicopathological features that may create diagnostic difficulties. In this study, 10 AdCCs, 8 PLGAs, and 5 normal minor salivary glands as a control group were selected. Sections prepared from each tumor were stained using the streptavidin-biotin system for seven marker antigens: carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), muscle-specific actin (MSA), vimentin, S100, p53, and Ki-67. Data analysis showed high expression of CEA, MSA and Ki-67 in AdCCs compared with PLGAs, although CEA expression was limited to luminal cells. Ki-67 was expressed in both luminal and non-luminal cells and MSA only in non-luminal cells. Vimentin and S100 showed stronger expression in PLGAs, the expression of vimentin was more noticeable, being focal and widespread. The immunoreactivities of EMA and P53 were not helpful for distinguishing between the two tumors, although the EMA expression pattern in AdCCs was limited to luminal cells, whereas it was present in both luminal and non-luminal cells in PLGAs. Thus, immunohistochemistry can be helpful for differential diagnosis of AdCC and PLGA, particularly that for CEA, vimentin, and Ki-67. (J Oral Sci 51, 509-514, 2009)

著者

Pari Ghaziani Navid Aghasizadeh Mahshid Sheikh-Nezami

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.49, no.4, pp.325-329, 2007 (Released:2008-01-15)

参考文献数

17

被引用文献数

10 22 25

---

Apexification with calcium hydroxide is associated with certain difficulties, such as the very long treatment time required, the possibility of tooth fracture, and incomplete calcification of the bridge. Use of an apical plug is an alternative treatment for open apices, and this has gained popularity in recent years, employing mineral trioxide aggregate (MTA) for optimal results. Here we report the successful treatment of two maxillary central incisors that had open apices and periapical lesions using MTA apical plugs after the root canals had been debrided and rinsed with 2.5% NaOCl. Calcium hydroxide paste was then placed in the canals for 1 week, before the apical portion of the canals (5 mm) was filled with the MTA plug. The remaining portion of the root canal was then sealed with a post and crown. After 6 months of follow-up, the clinical and radiographic appearance of the teeth showed a decrease of the periapical lesions. At 2 years, although the left post had been lost and the periapical lesion of the left central incisor had subsequently deteriorated, the right central incisor had healed successfully. Considering the importance of a coronal seal, the use of MTA for apical plugging appears to be a valid option. (J. Oral Sci. 49, 325-329, 2007)

著者

Masashi Miyazaki Akimasa Tsujimoto Keishi Tsubota Toshiki Takamizawa Hiroyasu Kurokawa Jeffrey A. Platt

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.56, no.1, pp.1-9, 2014 (Released:2014-03-15)

参考文献数

90

被引用文献数

8 61

---

Improvements in dentin bonding systems have influenced modern restorative dentistry. The desire for minimal invasiveness has resulted in more-conservative cavity design, which basically relies on the effectiveness of current dentin bonding systems. Interaction of adhesives with enamel and dentin is based on two systems, commonly described as etch-and-rinse and self-etch. Priming and bonding agents can be separate or combined, resulting in two- or three-step systems for etch-and-rinse adhesives and one- or two-step systems for self-etch adhesives. Self-etch systems use acidic functional monomers that simultaneously demineralize and impregnate tooth structures. Etch-and-rinse and self-etch systems have advantages and disadvantages, which are primarily related to the simplified bonding procedures required under clinical conditions. Knowledge of the composition, characteristics, and mechanisms of adhesion for each adhesive system is critical in selecting the ideal adhesive materials for clinical use. (J Oral Sci 56, 1-9, 2014)

著者

Yoshimi Kobayashi Makoto Hayashi Fumihiko Yoshino Muneaki Tamura Ayaka Yoshida Haruna Ibi Masaichi-Chang-il Lee Kuniyasu Ochiai Bunnai Ogiso

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.56, no.1, pp.35-39, 2014 (Released:2014-03-15)

参考文献数

28

被引用文献数

2 12

---

Chemomechanical procedures can be used to eliminate bacteria from root canals. However, detectable bacteria sometimes remain because of the complexity of the root canal system. Endodontic passive ultrasonic irrigation (PUI) with hydrogen peroxide (H2O2) may be a promising option for increasing bactericidal hydroxyl radical (HO•) generation. In this in vitro experiment, we examined the effects of HO• generated using PUI and a low concentration of H2O2. An ultrasonic tip was submerged in 0.45 mol/L (1.5%) H2O2 in a microfuge tube. H2O2 was activated by an ultrasonic unit, the tip of which was kept centered in the tube, to mimic PUI. HO• generation was detected by electron spin resonance spectroscopy. An Enterococcus faecalis suspension in H2O2 was then preparedand activated as described above. Bactericidal effects were assessed by viable counting. Two-way analysis of variance and Tukey’s test were used to assess the statistical significance of differences among groups (P < 0.05). HO• generation and bactericidal activity were significantly increased by PUI in H2O2 in a time-dependent manner and were significantly higher than with H2O2 alone or with PUI in a Tris-HCl suspension. These results suggest that PUI in the presence of a low H2O2 concentration is a promising new disinfection strategy. (J Oral Sci 56, 35-39, 2014)

著者

Mariele Pototski José M. Amenábar

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.49, no.4, pp.253-258, 2007 (Released:2008-01-15)

参考文献数

30

被引用文献数

28 60

---

Antiplatelet and anticoagulant agents have been extensively researched and developed as potential therapies in the prevention and management of arterial and venous thrombosis. On the other hand, antiplatelet and anticoagulant drugs have also been associated with an increase in the bleeding time and risk of postoperative hemorrhage. Because of this, some dentists still recommend the patient to stop the therapy for at least 3 days before any oral surgical procedure. However, stopping the use of these drugs exposes the patient to vascular problems, with the potential for significant morbidity. This article reviews the main antiplatelet and anticoagulant drugs in use today and explains the dental management of patients on these drugs, when subjected to minor oral surgery procedures. It can be concluded that the optimal INR value for dental surgical procedures is 2.5 because it minimizes the risk of either hemorrhage or thromboembolism. Nevertheless, minor oral surgical procedures, such as biopsies, tooth extraction and periodontal surgery, can safely be done with an INR lower than 4.0. (J. Oral Sci. 49, 253-258, 2007)