著者
藤井 節郎 中村 芳正 武田 節夫 森田 健一 佐藤 俊幸 丸中 照義 川口 安郎 采見 憲男
出版者
The Japanese Cancer Association
雑誌
GANN Japanese Journal of Cancer Research (ISSN:0016450X)
巻号頁・発行日
vol.71, no.1, pp.30-44, 1980-02-29 (Released:2008-10-23)
参考文献数
14

The metabolism, antitumor activity, and acute toxicity of 5-fluoro-1, 3-bis-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (FD-1) were investigated in animals, compared with 5-fluoro-1-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (FT). It was found that after oral administration of FD-1, the level of 5-fluorouracil (5-FU) was maintained higher and longer than after administration of FT, and that a large amount of 5-FU was released from FD-1 by liver microsomal drugmetabolizing enzymes or spontaneous hydrolysis via 5-fluoro-3-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (3-FT) and FT. FD-1 had a significant activity against the solid form of Ehrlich carcinoma, sarcoma-180, hepatoma AH130, Yoshida sarcoma, Walker carcinosarcoma-256, and leukemia L1210 and P388, but not the ascitic forms, and it produced greater inhibition of tumor growth than FT. The acute toxicity of FD-1 was less than that of FT.
著者
中島 松一 小野 史郎 林 宏仁
出版者
The Japanese Cancer Association
雑誌
GANN Japanese Journal of Cancer Research (ISSN:0016450X)
巻号頁・発行日
vol.65, no.5, pp.411-416, 1974-10-31 (Released:2008-10-23)
参考文献数
25

Both humoral and cell-mediated immunity were suppressed by four intravenous injections of 100μg each of 4-hydroxyaminoquinoline 1-oxide, employing bacterial α-amylase and picryl chloride as antigens. Preimmunization of mice with diazotized 4-aminoquinoline 1-oxide-conjugated rabbit serum protein by the use of complete Freund's adjuvant prevented immunosuppression by 4-hydroxyaminoquinoline 1-oxide. Anti-hapten titers of these mice were 25 to 28 estimated by passive hemagglutination during the course of the experiments. Passive immunization by transfer of the specific anti-hapten antibody induced prevention from immunosuppression by the reagent. Therefore, it was suggested that the humoral anti-hapten antibody might play an important role in preventing mice from immunosuppression by the reagent by preimmunization with the hapten-carrier conjugate.
著者
Shozo TAKAYAMA Yoko NAKATSURU Mitsunobu MASUDA Hiroko OHGAKI Shigeaki SATO Takashi SUGIMURA
出版者
The Japanese Cancer Association
雑誌
GANN Japanese Journal of Cancer Research (ISSN:0016450X)
巻号頁・発行日
vol.75, no.6, pp.467-470, 1984 (Released:2008-03-17)
参考文献数
22

The mutagenic compound 2-amino-3-methylimidazo[4, 5-f]quinoline, originally isolated from broiled sardines and also present in cooked beef and beef extract, is being tested for carcinogenicity in F344 rats of both sexes. High incidences of tumors of the Zymbal gland, colon, small intestine and liver in males have been observed in the first 300 days of the experiment.