著者

So Kanako Tei Yuna Zhao Meng Miyake Takahito Hiyama Haruka Shirakawa Hisashi Imai Satoshi Mori Yasuo Nakagawa Takayuki Matsubara Kazuo Kaneko Shuji

出版者

Nature Publishing Group

雑誌

Scientific Reports (ISSN:20452322)

巻号頁・発行日

vol.6, 2016-03-17

被引用文献数

34

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「しびれ」による痛みのメカニズムを解明 -糖尿病や血流障害によるしびれ治療薬の開発に期待-. 京都大学プレスリリース. 2016-03-18.

著者

Taylor J. Nicholas Li Chun-Biu Cooper David R. Landes Christy F. Komatsuzaki Tamiki

出版者

NATURE PUBLISHING GROUP

雑誌

Scientific Reports (ISSN:20452322)

巻号頁・発行日

vol.5, 2015-03-17

被引用文献数

14

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Characterization of states, the essential components of the underlying energy landscapes, is one of the most intriguing subjects in single-molecule (SM) experiments due to the existence of noise inherent to the measurements. Here we present a method to extract the underlying state sequences from experimental SM time-series. Taking into account empirical error and the finite sampling of the time-series, the method extracts a steady-state network which provides an approximation of the underlying effective free energy landscape. The core of the method is the application of rate-distortion theory from information theory, allowing the individual data points to be assigned to multiple states simultaneously. We demonstrate the method's proficiency in its application to simulated trajectories as well as to experimental SM fluorescence resonance energy transfer (FRET) trajectories obtained from isolated agonist binding domains of the AMPA receptor, an ionotropic glutamate receptor that is prevalent in the central nervous system.

著者

Hayakawa S. Kawai N. Masataka N.

出版者

Nature Publishing Group

雑誌

Scientific Reports (ISSN:20452322)

巻号頁・発行日

vol.1, 2011-09-01

被引用文献数

41

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なぜ人間と高等サル類のみで色覚は進化したのか. 京都大学プレスリリース. 2011-09-01

著者

Kojima Hisaya Tokizawa Riho Kogure Kouhei Kobayashi Yuki Itoh Masayuki Shiah Fuh-Kwo Okuda Noboru Fukui Manabu

出版者

Nature Publishing Group

雑誌

Scientific Reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-07-25

被引用文献数

31

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湖水中でのメタン消費の新たな主役 -亜熱帯ダム湖で脱窒メタン酸化細菌が優占していることを発見-. 京都大学プレスリリース. 2014-07-31.

著者

Maharjan Sunita Oku Masahide Tsuda Masashi Hoseki Jun Sakai Yasuyoshi

出版者

Nature Publishing Group

雑誌

Scientific Reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-07-31

被引用文献数

153

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タンパク質分解装置の活性低下が細胞死を引き起こす初期経路の同定と食品成分による回復. 京都大学プレスリリース. 2014-07-31.

著者

Horie Takahiro Nishino Tomohiro Baba Osamu Kuwabara Yasuhide Nakao Tetsushi Nishiga Masataka Usami Shunsuke Izuhara Masayasu Nakazeki Fumiko Ide Yuya Koyama Satoshi Sowa Naoya Yahagi Naoya Shimano Hitoshi Nakamura Tomoyuki Hasegawa Koji Kume Noriaki Yokode Masayuki Kita Toru Kimura Takeshi Ono Koh

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-06-16

被引用文献数

44

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マウスへのマイクロRNA-33bの導入に成功 -ヒトでのHDL-コレステロールの質の改善に期待-. 京都大学プレスリリース. 2014-06-17.

著者

Ikuta Junya Kamisetty Nagendra K Shintaku Hirofumi Kotera Hidetoshi Kon Takahide Yokokawa Ryuji

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014

被引用文献数

16

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「分子綱引き」をおこなうナノシステムを開発 -細胞分裂や細胞内物質輸送の仕組みを知るカギに-.京都大学プレスリリース. 2014-06-17.

著者

Shimono Kohei Fujishima Kazuto Nomura Takafumi Ohashi Masayoshi Usui Tadao Kengaku Mineko Toyoda Atsushi Uemura Tadashi

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-03-19

被引用文献数

30

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体の大きさに合わせて神経細胞の大きさを制御するしくみを解明. 京都大学プレスリリース. 2014-03-17.

著者

Tex David M Kamiya Itaru Kanemitsu Yoshihiko

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-02-18

被引用文献数

26

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量子ナノ構造を利用した太陽電池の光キャリアの振る舞いを解明 -高効率太陽電池の実現に前進-.京都大学プレスリリース.2014-2-18.

著者

Aihara Ikkyu Mizumoto Takeshi Otsuka Takuma Awano Hiromitsu Nagira Kohei Okuno Hiroshi G Aihara Kazuyuki

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-01-27

被引用文献数

53

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カエルの合唱の法則を数学と光計測を使って発見. 京都大学プレスリリース. 2014-01-27.

著者

Tayagaki Takeshi Hoshi Yusuke Usami Noritaka

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.3, 2013

被引用文献数

64

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量子ドットを用いた結晶シリコン太陽電池の高効率化に向けた設計指針を提供. 京都大学プレスリリース. 2013-09-26.

著者

Nakamichi Yusuke Yoshioka Aya Kawai Shigeyuki Murata Kousaku

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.3, 2013-09-11

被引用文献数

17

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ATP特異性の獲得メカニズムの解明 : 新薬と新しい物質生産系の開発に期待. 京都大学プレスリリース. 2013-09-11.

著者

Kuwayama Hidekazu Ishida Shuji

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.3, pp.2272, 2013-07

被引用文献数

48

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Solitons have been observed in various physical phenomena. Here, we show that the distinct characteristics of solitons are present in the mass cell movement of non-chemotactic mutants of the cellular slime mould Dictyostelium discoideum. During starvation, D. discoideum forms multicellular structures that differentiate into spore or stalk cells and, eventually, a fruiting body. Non-chemotactic mutant cells do not form multicellular structures; however, they do undergo mass cell movement in the form of a pulsatile soliton-like structure (SLS). We also found that SLS induction is mediated by adhesive cell-cell interactions. These observations provide novel insights into the mechanisms of biological solitons in multicellular movement.

著者

Komatsu Tetsuro Sekiya Takeshi Nagata Kyosuke

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.3, pp.2187, 2013-07

被引用文献数

14

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The expression of adenovirus late genes is shown to require viral DNA replication, but its mechanism remains elusive. Here we found that knockdown of CTCF suppresses viral DNA replication as well as late, but not early, gene expression. Chromatin immunoprecipitation assays indicated that CTCF binds to viral chromatin depending on viral DNA replication. These findings depict CTCF as a critical regulator for adenovirus genome functions in late phases of infection.

著者

Kawasaki Masahiro Yamada Yohei Ushiku Yosuke Miyauchi Eri Yamaguchi Yoko

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.3, pp.1692, 2013-04

被引用文献数

146 9

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Behavioral rhythms synchronize between humans for communication; however, the relationship of brain rhythm synchronization during speech rhythm synchronization between individuals remains unclear. Here, we conducted alternating speech tasks in which two subjects alternately pronounced letters of the alphabet during hyperscanning electroencephalography. Twenty pairs of subjects performed the task before and after each subject individually performed the task with a machine that pronounced letters at almost constant intervals. Speech rhythms were more likely to become synchronized in human–human tasks than human–machine tasks. Moreover, theta/alpha (6–12 Hz) amplitudes synchronized in the same temporal and lateral-parietal regions in each pair. Behavioral and inter-brain synchronizations were enhanced after human–machine tasks. These results indicate that inter-brain synchronizations are tightly linked to speech synchronizations between subjects. Furthermore, theta/alpha inter-brain synchronizations were also found in subjects while they observed human–machine tasks, which suggests that the inter-brain synchronization might reflect empathy for others' speech rhythms.

著者

Hirata Satoshi Matsuda Goh Ueno Ari Fukushima Hirokata Fuwa Koki Sugama Keiko Kusunoki Kiyo Tomonaga Masaki Hiraki Kazuo Hasegawa Toshikazu

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.3, 2013-02-26

被引用文献数

14

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チンパンジーも他者の表情を素早く察知 -脳波測定による解明-.京都大学プレスリリース. 2013-02-26.

著者

Kuwayama Hidekazu

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.2, pp.577, 2012-08

被引用文献数

7

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Caffeine is a globally consumed psychostimulant but can be fatal to cells at overdose exposures. Although caspase-dependent apoptosis plays a role in caffeine-induced cell death, the responsible intracellular signalling cascade remains incompletely understood. The cellular slime mould, Dictyostelium discoideum, does not possess caspase-dependent apoptotic machinery. Here, we observed that ablation of D. discoideum plaA, which encodes a phospholipase A2 (PLA2) homolog, leads to a decreased rate of cell death under high caffeine concentrations and to enhanced cell death with the addition of arachidonic acid. Moreover, the inhibition of PLA2 activity lead to a recovery of the survival rate in caspase-inhibited Hela cervical carcinoma cells under high caffeine concentrations, indicating that caffeine-induced cell death is enhanced via PLA2-dependent signalling. Our results indicate that arachidonic acid may be a general second messenger that negatively regulates caffeine tolerance via a caspase-independent cell death cascade, which leads to multiple effects in eukaryotic cells.