著者

植村 雅子 米田 誠治

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.26, no.4, pp.157-165, 2016-03-22 (Released:2016-04-14)

参考文献数

43

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Platinum-based anticancer drugs, represented by cisplatin, play important roles in present cancer chemotherapy. Although three or five platinum-based drugs have been approved for clinical use worldwide or in Japan, many active researches are still ongoing to seek next generation platinum-based drugs with less side effect and higher efficacy. Tetrazolato-bridged dinuclear platinum(II) complexes (tetrazolato-bridged complex) are distinctively different from existing platinum-based drugs in cytotoxicity spectra, DNA interactions, and cellular uptake profiles, probably due to their unique structures. Tetrazolato-bridged complexes provide high in vivo antitumor activity toward pancreatic cancer which is difficult to cure. In this review, we introduce the recent drug development researches on platinum-based drugs and update the latest findings of tetrazolato-bridged complex.

著者

Manfred Anke Wolfram Dorn Mario Müller Mathias Seifert

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.3, pp.198-202, 2005 (Released:2006-04-20)

参考文献数

19

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Cadmium-poor nutrition (< 15 μg Cd/kg feed dry matter (DM)) did not affect feed intake and growth rate, while it affected reproduction performance. Intrauterinally cadmium-depleted kids were often phlegmatic, too lazy to eat and drink, and died of muscle weakness. With oral application of the control feed (300 μg Cd/kg DM), they slowly regained their mobility. Feeding them 65 μg Cd/kg feed DM prevented myasthenia. The normative cadmium requirement of goats (and animals in general) amounts to < 20 μg/kg diet DM. The daily requirement of humans might be < 3 μg.

著者

Hiroshi Yasuda Toshie Yonashiro Kazuya Yoshida Tomiko Ishii Toyoharu Tsutsui

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.4, pp.285-292, 2005 (Released:2006-07-19)

参考文献数

35

被引用文献数

4

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In order to investigate any role of minerals in autistic disorders, we measured 24 mineral contents in scalp hair samples of 360 autistic children and compared with those of healthy controls. In the male autistic group aged 4-9 years (N=200), the geometric means of many element levels, namely not only essential minerals such as cobalt, chromium, iodine, molybdenum and phosphorus, but also nickel, boron, cadmium and lead were significantly lower than those in the control group (p<0.001). In contrast, selenium level was significantly higher in the autistic group. On the mercury levels, no significant difference was observed between the two groups, though with a tendency of low concentration in the autistic group. Similar mineral imbalance profiles with a global mineral deficiency were observed in the other autistic groups aged 0-3 and 10-15 years (N=85 and 20) and also in the female autistic groups. In addition, high accumulation of a few elements such as iron, manganese, chromium, copper, sodium, aluminum, cadmium, lead, or mercury was observed in some autistic individuals. These findings indicate that autistic children are suffered from a global mineral deficiency in various trace elements, with some individuals being exposed to a marked accumulation of several elements. Autistic children may be classified to sub-groups, based on their mineral imbalance profile in hair.

著者

大村 実

出版者

日本微量元素学会

雑誌

Biomedical research on trace elements (ISSN:0916717X)

巻号頁・発行日

vol.13, no.3, pp.149-157, 2002-09-30