文献一覧: NATURE PUBLISHING GROUP (出版者)

1 0 0 0 OA Basophils are required for the induction of Th2 immunity to haptens and peptide antigens

著者: Otsuka Atsushi Nakajima Saeko Kubo Masato Egawa Gyohei Honda Tetsuya Kitoh Akihiko Nomura Takashi Hanakawa Sho Sagita Moniaga Catharina Kim Bongju Matsuoka Satoshi Watanabe Takeshi Miyachi Yoshiki Kabashima Kenji
出版者: Nature Publishing Group
雑誌: Nature Communications (ISSN:20411723)
巻号頁・発行日: vol.4, 2013-04-23
被引用文献数: 93

ハプテンやペプチド抗原に対するTh2誘導に好塩基球が必須である. 京都大学プレスリリース. 2013-04-24.

2013-04-25 11:23:35
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1 0 0 0 OA Pituitary Tumor-Transforming Gene 1 Enhances Proliferation and Suppresses Early Differentiation of Keratinocytes

著者: Ishitsuka Yosuke Kawachi Yasuhiro Taguchi Shijima Maruyama Hiroshi Fujisawa Yasuhiro Furuta Junichi Nakamura Yasuhiro Otsuka Fujio
出版者: Nature Publishing Group
雑誌: Journal of investigative dermatology (ISSN:0022202X)
巻号頁・発行日: vol.132, no.7, pp.1775-1784, 2012-07
被引用文献数: 14 4

The epidermis is a self-renewing tissue, the homeostasis of which is dependent upon the tight balance between proliferation and differentiation based on appropriate regulation of the cell cycle. The cell cycle regulation is dependent on the interactions among a number of cell cycle regulatory molecules, including the pituitary tumor-transforming gene 1 (PTTG1), also known as securin, a regulator of sister chromatid separation and transition from metaphase to anaphase. This study was conducted to clarify the less-known functions of PTTG1 in the epidermis by the use of keratinocytes cultured under two-dimensional (2D) or three-dimensional (3D) conditions. Forced overexpression of PTTG1 caused upregulation of cyclin B1, cyclin-dependent kinase 1 (CDK1), and c-Myc, resulting in enhanced proliferation and suppression of early differentiation without apparent alterations in terminal differentiation, and the exogenous PTTG1 was downregulated in association with cell cycle exit. In contrast, depletion of PTTG1 caused their downregulation and constrained proliferation with retention of differentiation capacity. These findings suggested that PTTG1 could alter the proliferation status by modulating the expression levels of the other cell cycle regulatory proteins, and excess PTTG1 primarily affects early differentiation of keratinocytes under the stability regulation associated with cell cycle exit.

2013-03-06 08:30:28
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1 0 0 0 OA Brain response to affective pictures in the chimpanzee.

著者: Hirata Satoshi Matsuda Goh Ueno Ari Fukushima Hirokata Fuwa Koki Sugama Keiko Kusunoki Kiyo Tomonaga Masaki Hiraki Kazuo Hasegawa Toshikazu
出版者: Nature Publishing Group
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.3, 2013-02-26
被引用文献数: 14

チンパンジーも他者の表情を素早く察知 -脳波測定による解明-.京都大学プレスリリース. 2013-02-26.

2013-03-04 09:30:01
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1 0 0 0 OA The effect of oral management on the severity of oral mucositis during hematopoietic SCT

著者: Yamagata K Arai C Sasaki H Takeuchi Y Onizawa K Yanagawa T Ishibashi N Karube R Shinozuka K Hasegawa Y Chiba S Bukawa H
出版者: Nature Publishing Group
雑誌: Bone marrow transplantation (ISSN:02683369)
巻号頁・発行日: vol.47, pp.725-730, 2012-05
被引用文献数: 25 6

Oral mucositis (OM) is a frequent adverse effect of allogenic or autologous hematopoietic SCT. It results from direct toxic injury to the mucosal epithelial cells by the immunosuppressive regimen. Here, we compared the incidence and severity of OM between a group of 24 patients who received proper oral management during hematopoietic SCT and a group of 24 who did not. The oral management group received pre-hematopoietic SCT instruction on oral care and an oral examination in the clean room. Differences in the incidence and severity of OM between the two groups were examined statistically. OM was observed in 14 (58.3%) patients in the oral management group and 22 (91.6%) in the control group. The median of the OM score was 1 for the oral management group (range 0 to 3) and 2 for the control group (range 0 to 3). There was a significant difference in the OM score (P<0.05) and in the incidence of OM between the two groups (P<0.01). This study shows that oral management may decrease the occurrence of OM. Our results also suggest that it is important to include an oral management provider on the hematopoietic SCT team.

2013-02-16 08:30:57
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1 0 0 0 OA Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells

著者: Miyazaki Takamichi Futaki Sugiko Suemori Hirofumi Taniguchi Yukimasa Yamada Masashi Kawasaki Miwa Hayashi Maria Kumagai Hideaki Nakatsuji Norio Sekiguchi Kiyotoshi Kawase Eihachiro
出版者: Nature Publishing Group
雑誌: Nature communications (ISSN:20411723)
巻号頁・発行日: vol.3, 2012-12-04
被引用文献数: 287

細胞接着タンパクを用い、安全・高効率なヒトES / iPS細胞の培養法を開発 : 幹細胞実用化に必要な品質保証・大量生産に向けて前進. 京都大学プレスリリース. 2012-12-05.

2012-12-11 13:50:18
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1 0 0 0 OA Meat consumption in relation to mortality from cardiovascular disease among Japanese men and women

著者: Nagao M Iso H Yamagishi K Date C Tamakoshi A the JACC Study Group
出版者: Nature Publishing Group
雑誌: European journal of clinical nutrition (ISSN:09543007)
巻号頁・発行日: vol.66, no.6, pp.687-693, 2012-06
被引用文献数: 60

BACKGROUND/OBJECTIVES:Although high or low (no) meat consumption was associated with elevated or reduced mortality from cardiovascular disease, respectively, few studies have investigated the association between moderate meat consumption and cardiovascular disease. We aimed to evaluate the associations between moderate meat consumption and cardiovascular disease mortality.SUBJECTS/METHODS:We conducted a prospective cohort study of 51,683 Japanese (20,466 men and 31,217 women) aged 40-79 years living in all of Japan (The Japan Collaborative Cohort Study; JACC Study). Consumptions of meat (beef, pork, poultry, liver and processed meat) were assessed via a food frequency questionnaire administrated at baseline survey. Hazard ratios (HRs) of mortality from cardiovascular disease were estimated from Cox proportional hazards regression models according to quintiles of meat consumption after adjustment for potential confounding variables.RESULTS:During 820,076 person-years of follow-up, we documented 2685 deaths due to total cardiovascular disease including 537 ischemic heart diseases and 1209 strokes. The multivariable HRs (95% confidence interval) for the highest versus lowest quintiles of meat consumption (77.6 versus 10.4 g/day) among men were 0.66 (0.45-0.97) for ischemic heart disease, 1.10 (0.84-1.43) for stroke and 1.00 (0.84-1.20) for total cardiovascular disease. The corresponding HRs (59.9 versus 7.5 g/day) among women were 1.22 (0.81-1.83), 0.91 (0.70-1.19) and 1.07 (0.90-1.28). The associations were similar when the consumptions of red meat, poultry, processed meat and liver were examined separately.CONCLUSION:Moderate meat consumption, up to ~100 g/day, was not associated with increased mortality from ischemic heart disease, stroke or total cardiovascular disease among either gender.

2012-12-11 08:30:17
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1 0 0 0 OA Angiosarcoma of the scalp diagnosed by the presence of neck inflammation: a case report

著者: Karube Rei Sasaki Hiroyoshi Shinozuka Keiji Fujisawa Yasuhiro Yanagawa Toru Yamagata Kenji Onizaw Kojiro Otsuka Fujio Bukawa Hiroki
出版者: Nature Publishing Group
雑誌: International Journal of Oral Science (ISSN:16742818)
巻号頁・発行日: vol.4, no.3, pp.166-169, 2012-09
被引用文献数: 6 2

Angiosarcoma is an uncommon malignancy, which spread out from the endothelial cells of vessels. Scalp angiosarcoma with cervical lymph node metastasis is particularly rare. This article describes a rare case of angiosarcoma of the scalp, presenting as neck inflammation. Imaging procedures such as computed tomography (CT), magnetic resonance image (MRI) and ultrasonography (US) were not sufficient to diagnose this case. A needle biopsy provided an effective and accurate diagnosis of cervical lymph node metastasis. Additional observation and physical examination was required to diagnose the origin of the primary cancerous lesion. Once the angiosarcoma diagnosis was confirmed histologically, sequential weekly and monthly docetaxel (DTX) treatment was effective in preventing reoccurrence. Nonetheless, the optimization of angiosarcoma treatment remains a future goal. Although patients generally describe pain and swelling at the primary lesion site, this patient complained only of painful neck inflammation, without any indication of pain or swelling of the scalp. A revised diagnostic protocol should note that cervical lymph node metastasis of unknown primary origin may result from angiosarcoma of the scalp.

2012-11-28 08:30:35
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1 0 0 0 OA Arachidonic Acid Enhances Caffeine-Induced Cell Death via Caspase-Independent Cell Death

著者: Kuwayama Hidekazu
出版者: Nature Publishing Group
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.2, pp.577, 2012-08
被引用文献数: 7

Caffeine is a globally consumed psychostimulant but can be fatal to cells at overdose exposures. Although caspase-dependent apoptosis plays a role in caffeine-induced cell death, the responsible intracellular signalling cascade remains incompletely understood. The cellular slime mould, Dictyostelium discoideum, does not possess caspase-dependent apoptotic machinery. Here, we observed that ablation of D. discoideum plaA, which encodes a phospholipase A2 (PLA2) homolog, leads to a decreased rate of cell death under high caffeine concentrations and to enhanced cell death with the addition of arachidonic acid. Moreover, the inhibition of PLA2 activity lead to a recovery of the survival rate in caspase-inhibited Hela cervical carcinoma cells under high caffeine concentrations, indicating that caffeine-induced cell death is enhanced via PLA2-dependent signalling. Our results indicate that arachidonic acid may be a general second messenger that negatively regulates caffeine tolerance via a caspase-independent cell death cascade, which leads to multiple effects in eukaryotic cells.