著者
Wakaba Fukushima Megumi Hara Yuri Kitamura Masahiko Shibata Yoshikazu Ugawa Koichi Hirata Akira Oka Shinya Miyamoto Susumu Kusunoki Satoshi Kuwabara Shuji Hashimoto Tomotaka Sobue
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.32, no.1, pp.34-43, 2022-01-05 (Released:2022-01-05)
参考文献数
50
被引用文献数
7

Background: Since June 2013, Japan has suspended proactive recommendation of human papillomavirus (HPV) vaccination due to self-reported diverse symptoms, including pain and motor dysfunction, as possible serious adverse events following immunization. Although these symptoms may be seen in adolescents without HPV vaccination, their frequency, taking into account disease severity, has not been examined.Methods: A two-stage, descriptive, nationwide epidemiological survey was conducted in 2016, with a 6-month target period from July 1 to December 31, 2015, to estimate the prevalence and incidence of diverse symptoms among Japanese adolescents without HPV vaccination. Participants were 11,037 medical departments in hospitals selected nationwide by stratified random sampling. Eligible patients had to satisfy four criteria: (1) aged 12–18 years upon visiting hospital; (2) having at least one of four symptoms/disorders (pain or sensory dysfunction, motor dysfunction, autonomic dysfunction, or cognitive impairment); (3) symptoms/disorders persisting for at least 3 months; and (4) both criteria (2) and (3) influence attendance at school or work. We then extracted data of patients with diverse symptoms similar to those after HPV vaccination while considering opinions of doctors in charge.Results: Estimated 6-month period prevalence of diverse symptoms among girls aged 12–18 years without HPV vaccination was 20.2 per 100,000. Annual incidence was estimated to be 7.3 per 100,000.Conclusion: Adolescent Japanese girls without HPV vaccination also visited hospitals with diverse symptoms similar to those following HPV vaccination. Our findings predict the medical demands for coincident diverse symptoms, which are temporally associated with but not caused by HPV vaccination of Japanese adolescents.

言及状況

外部データベース (DOI)

Twitter (10 users, 19 posts, 9 favorites)

https://t.co/YUM5U4wFDG ・本研究の目的は、HPVワクチン接種歴のない日本人青少年について、「重篤である多様な症状」の有訴率と発症率を推定することである。 ・2016年に、全国規模の記述疫学研究を実施した。調査対象期間は2015年7月~12月の6ヵ月間とした→
Thank You Authors Campaign 2022: A Nationwide Epidemiological Survey of Adolescent Patients With Diverse Symptoms Similar to Those Following Human Papillomavirus Vaccination: Background Prevalence and Incidence Fukushima, W, et al. https://t.co/Mdvj7JFHKn #JE_ThankYouAuthors2022 https://t.co/5Ea69fH0fX
https://t.co/Lly1cB84p2 A Nationwide Epidemiological Survey of Adolescent Patients With Diverse Symptoms Similar to Those Following Human Papillomavirus Vaccination: Background Prevalence and Incidence for Considering Vaccine Safety in Japan →祖父江班の論文
A Nationwide Epidemiological Survey of Adolescent Patients With Diverse Symptoms Similar to Those Following Human Papillomavirus Vaccination: Background Prevalence and Incidence for Considering Vaccine Safety in Japan https://t.co/sy4cFTvCiW →祖父江班の疫学調査が論文化された!
https://t.co/e4xtles6Rc 問題のデータ Figure 2. Estimated period prevalence (per 100,000 population) during the period of July to December 2015 among girls with diverse symptoms, according to the number of symptoms. →多数のバイアスがあるため、統計処理は実施しないと明記している。
A Nationwide Epidemiological Survey of Adolescent Patients With Diverse Symptoms Similar to Those Following Human Papillomavirus Vaccination: Background Prevalence and Incidence for Considering Vaccine Safety in Japan https://t.co/sy4cFTdt4O #祖父江班 #HPVワクチン #副反応
HPVワクチンを受けなかった人も受けた人と同じ程度の有病率ということなのかな? でも、受けられなかったくらい健康状態が悪い集団との比較って どういう意味があるんだろう? 選択バイアスはどう外したのかな? https://t.co/NOzQawetAe
こちらかな ? 祖父江友孝氏の 名前 ありませんが ... https://t.co/JHBL2J3lsK
この記事https://t.co/Vo1Pd7enCF とこの記事https://t.co/y2K4eNdihh で紹介されている阪大祖父江先生の調査結果(思春期には体の痛みや不調がHPVワクチン接種の有無を問わず一定割合で出現)はここhttps://t.co/jgOVoMOlBh に英語論文として公表(掲載雑誌は日本疫学会の公式英語論文誌2022年1月号)

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