著者
宗 村盛 鈴木 豊史 高野 賢児 島田 侯陛 井上 真由美 川井 龍美 深水 啓朗 伴野 和夫
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.133, no.5, pp.587-595, 2013-05-01 (Released:2013-05-01)
参考文献数
28
被引用文献数
1 1

Japanese patients with normal renal function were retrospectively analyzed to characterize increases in serum creatinine (SCr) observed following the use of a sulfamethoxazole-trimethoprim (SMX-TMP) combination product and identify factors affecting these increases. In the patients studied (n=49), an individual comparison was conducted for the three factors of age group [≤74 years (n=21) vs. ≥75 years (n=28)], sex [male (n=24) vs. female (n=25)], and total dose throughout the treatment period [≤7 g (n=24) vs. ≥8 g (n=25)] to determine the extent of SCr increase following SMX-TMP combination product use. SCr increased significantly following SMX-TMP combination product use in patients ≤74 years of age and ≥75 years of age, in both males and females, and in patients with a total dose of ≥8 g (8 to 96 g) (p<0.05). Multivariate logistic regression analysis was used to determine the independence of these factors. Total dose was identified as an independent factor and had an odds ratio of 6.571 [95% confidence interval=1.735-24.882, p=0.006]. Post-treatment percent increases in SCr were compared using pre-treatment levels as the baseline. The group with a total dose of ≥8 g (mean 29.8 g) had a significant SCr increase of 18.4% (p=0.002), while the increase in the ≤7 g (mean 5.3 g) group was only 4.5%. The data showed that SCr increased by about 20% when the total dose taken over the treatment period was around 30 g (about 2.4 g as TMP) and indicated that total dose contributes more than age and sex to the post-treatment increase in SCr.

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@kameco875 Wantanco先生のおっしゃるように、10%以上の報告もあるみたいですね。 https://t.co/iEwVRw3aCJ
ST合剤で上昇するクレアチニンは20%程度とする報告が多い。なのでこの程度なら腎機能障害ではないと判断してよさげ。カリウムのモニターは必要 https://t.co/Ta2ld4eLQG https://t.co/iM0gnIPDha
ST合剤によるクレアチニン上昇は腎機能障害でない,という言葉に語弊があるので追記.STによるクレアチニン上昇はせいぜい20%程度で0.5とか1とか上昇しません.後方視的解析ですがソース:https://t.co/gxWf1WQfq8 https://t.co/7eKfPpyV6g
@kameco875 あとは、こちらか…。 スルファメトキサゾール/トリメトプリム配合剤の投与による血清クレアチニン の上昇とその要因:正常な腎機能を有する日本人患者を対象とした遡及的解析 https://t.co/eS2vJmDGAA
備忘録。 薬学雑誌 Vol.133 (2013) No.5 p.587-595 スルファメトキサゾール/トリメトプリム配合剤の投与による血清クレアチニンの上昇とその要因:正常な腎機能を有する日本人患者を対象とした遡及的解析 https://t.co/kTAJe81xE1

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