著者

宗 村盛 鈴木 豊史 高野 賢児 島田 侯陛 井上 真由美 川井 龍美 深水 啓朗 伴野 和夫

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.5, pp.587-595, 2013-05-01 (Released:2013-05-01)

参考文献数

28

被引用文献数

1 2

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Japanese patients with normal renal function were retrospectively analyzed to characterize increases in serum creatinine (SCr) observed following the use of a sulfamethoxazole-trimethoprim (SMX-TMP) combination product and identify factors affecting these increases. In the patients studied (n=49), an individual comparison was conducted for the three factors of age group [≤74 years (n=21) vs. ≥75 years (n=28)], sex [male (n=24) vs. female (n=25)], and total dose throughout the treatment period [≤7 g (n=24) vs. ≥8 g (n=25)] to determine the extent of SCr increase following SMX-TMP combination product use. SCr increased significantly following SMX-TMP combination product use in patients ≤74 years of age and ≥75 years of age, in both males and females, and in patients with a total dose of ≥8 g (8 to 96 g) (p<0.05). Multivariate logistic regression analysis was used to determine the independence of these factors. Total dose was identified as an independent factor and had an odds ratio of 6.571 [95% confidence interval=1.735-24.882, p=0.006]. Post-treatment percent increases in SCr were compared using pre-treatment levels as the baseline. The group with a total dose of ≥8 g (mean 29.8 g) had a significant SCr increase of 18.4% (p=0.002), while the increase in the ≤7 g (mean 5.3 g) group was only 4.5%. The data showed that SCr increased by about 20% when the total dose taken over the treatment period was around 30 g (about 2.4 g as TMP) and indicated that total dose contributes more than age and sex to the post-treatment increase in SCr.

著者

山本 佳久 鎌野 衛 深水 啓朗 古石 誉之 鈴木 豊史 梅田 由紀子 牧村 瑞恵 伴野 和夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.31, no.8, pp.625-631, 2005-08-10 (Released:2011-03-04)

参考文献数

8

被引用文献数

2 1

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A general method of administering powdered medicines to infants is to add a spoonful of water to the powder to make a paste and then making the paste into small dumpling-sized balls. We investigated the optimal amount of water for making a paste for 35 kinds of powdered medicine which included fine granules, granules and dry syrups. The optimal water amount was expressed as an amount per gram of powder. Approximately 80% of the powders examined in this study required 0.2-0.4 mL of water per gram of powder to make a paste that would form small balls. Optimal water amounts were calculated for amounts of powder ranging between 0.1 and 1.5 grams by proportion and when the calculated amounts of water were added, small dumpling sized balls could be formed. In the same way, we also calculated amounts of water required for powdered mixtures of several medicines for 6 prescriptions often prescribed in our pharmacy from corrected standard volumes for each medicine in the mixture. The amounts of water added on this basis achieved the required paste state for all of the powder mixtures used. These results suggest that the optimal water amount for powdered medicines of various weights can be estimated from standard volumes of water by proportion. Thus, optimal water amounts determined by our method may be useful for the administration of mixed powdered medicines to infants.

著者

鈴木 豊史 鈴木 直人 金沢 貴憲

出版者

公益社団法人 日本油化学会

雑誌

オレオサイエンス (ISSN:13458949)

巻号頁・発行日

vol.20, no.2, pp.61-69, 2020 (Released:2020-02-06)

参考文献数

30

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血液-脳関門(BBB)は,全身投与後の薬物を脳に送達する際の主要な障壁である。中枢神経疾患に対する治療薬の創薬開発は,薬物を脳に選択的かつ効率的に送達する技術の開発が律速であるため,他の疾患領域と比べ特に困難を極めている。鼻腔内経路は,経口および非経口経路を超えるいくつかの利点を有する。なかでも経鼻投与された薬物は,BBBを迂回することができ,主に嗅覚および三叉神経経路に沿った輸送を介してさまざまな脳領域に分布する。そのため,鼻腔内経路は中枢神経疾患に対する治療薬を脳に直接送達できる非侵襲的で簡便な投与経路として注目され,ナノシステムの利用により近年脳に薬物を標的化できる可能性が示されている。本総説では,鼻腔内からの薬物吸収性,鼻から脳への薬物送達に関与する輸送機構と鼻腔内薬物送達に利用されるナノシステムの役割について,我々の最近の知見を交えて概説したい。

著者

福田 春香 鈴木 豊史 橋崎 要 吉村 彩也香 小林 千翔 重谷 美子 鈴木 直人 金沢 貴憲 深水 啓朗 山本 佳久

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.2, pp.299-308, 2019-02-01 (Released:2019-02-01)

参考文献数

21

被引用文献数

2

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To clarify the volume of water required to paste pediatric powders, we herein established a standard for the powder paste state by measuring yield values when water was added to powders. The powders used in the present study were selected from 8 types including original and generic drugs. Tipepidine hibenzate is prescribed in the pediatric field in combination with ambroxol hydrochloride and l-carbocysteine. The volumes of water needed to achieve the paste state of ambroxol hydrochloride between the original and generic drugs were similar. However, the volumes of water needed for l-carbocysteine markedly differed between the original and generic drugs due to differences in their additives. The spreadability of the mixture when water was added to the powders was evaluated using a spread meter. Among the powders tested in the present study, the yield value to achieve a paste state with the addition of water was approximately 1000 dyne/cm2. The optimum volume of water estimated from this yield value using the linear proportional relationship for the amount of powder may be applied to the mixture of each pediatric power for dosage/body weight.

著者

深水 啓朗 山本 佳久 中村 裕美子 鎌野 衛 梅田 由紀子 牧村 瑞恵 古石 誉之 鈴木 豊史 伴野 和夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.32, no.9, pp.964-969, 2006-09-10 (Released:2007-11-09)

参考文献数

17

被引用文献数

17 15

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We investigated the uniformity of content, rheological properties and chemical stability for prescription of Kindavate® ointment diluted with white petrolatum. When the ointment was levigated with white petrolatum (Propeto® for dilution) by a pharmacist or mixed by an autorotation/orbital mechanical mixer, a uniform ointment having the precise drug content could be prepared for all conditions. However, as the dilution ratio increased, the hardness of the ointment seemed to decrease based on the yield point measured with a spread meter and apparent absolute viscosity. Also, using a polarizing microscope, we observed a dispersion of oil droplets (consisting of liquid paraffin in clobetasone butyrate) in petrolatum for both Kindavate® ointment and the diluted ointment showing that the internal structure of ointment had not been affected by preparation of the diluted ointment either manually by pharmacists or using the mechanical mixer. When the diluted ointment was stored at 4 or 25°C in tight container in the absence of light, it was chemically stable for at least a month.Since our results showed that Kindavate® ointment diluted with petrolatum had a precise drug content and was stable over time, it should be feasible to prepare the ointment in advance of use.

著者

山本 佳久 鈴木 豊史 深水 啓朗 鎌野 衛 伴野 和夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.34, no.7, pp.691-698, 2008 (Released:2010-02-07)

参考文献数

22

被引用文献数

1 2

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We determined the adhesion loss in a metering glass for 9 types of syrup for infants,and investigated the relationship between the adhesion loss and the rheological properties of the syrups.There was a good correlation (r2=0.981)between the viscosity of the syrups and percentage syrup residues on the metering glass.Further,from the viewpoints of accuracy and efficiency in dispensing,our finding that percentage residues for a dispenser were much lower (<0.15%) than for the metering glass suggested that it was better to use a dispenser for dispensing viscous syrups with a viscosity of at least 50-60 mPa·s.The results of our examination of syrup viscosities in the present study are expected to be useful information for their administration,and to contribute to the establishment of dispensing procedures based on scientific evidence.