著者
宗 村盛 鈴木 豊史 高野 賢児 島田 侯陛 井上 真由美 川井 龍美 深水 啓朗 伴野 和夫
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.133, no.5, pp.587-595, 2013-05-01 (Released:2013-05-01)
参考文献数
28
被引用文献数
1 1

Japanese patients with normal renal function were retrospectively analyzed to characterize increases in serum creatinine (SCr) observed following the use of a sulfamethoxazole-trimethoprim (SMX-TMP) combination product and identify factors affecting these increases. In the patients studied (n=49), an individual comparison was conducted for the three factors of age group [≤74 years (n=21) vs. ≥75 years (n=28)], sex [male (n=24) vs. female (n=25)], and total dose throughout the treatment period [≤7 g (n=24) vs. ≥8 g (n=25)] to determine the extent of SCr increase following SMX-TMP combination product use. SCr increased significantly following SMX-TMP combination product use in patients ≤74 years of age and ≥75 years of age, in both males and females, and in patients with a total dose of ≥8 g (8 to 96 g) (p<0.05). Multivariate logistic regression analysis was used to determine the independence of these factors. Total dose was identified as an independent factor and had an odds ratio of 6.571 [95% confidence interval=1.735-24.882, p=0.006]. Post-treatment percent increases in SCr were compared using pre-treatment levels as the baseline. The group with a total dose of ≥8 g (mean 29.8 g) had a significant SCr increase of 18.4% (p=0.002), while the increase in the ≤7 g (mean 5.3 g) group was only 4.5%. The data showed that SCr increased by about 20% when the total dose taken over the treatment period was around 30 g (about 2.4 g as TMP) and indicated that total dose contributes more than age and sex to the post-treatment increase in SCr.
著者
井上 真由美
出版者
一般社団法人 軽金属学会
雑誌
軽金属 (ISSN:04515994)
巻号頁・発行日
vol.16, no.3, pp.147-156, 1966-05-31 (Released:2008-10-30)
参考文献数
30
被引用文献数
2 2

In Japan Air Self-Defense Force, serious corrosion problems were encountered, regarding to the presence of the microorganisms in JP-4 fuel. Fuel was dripping from a tank in jet fuel aircraft. Microorganisms were cultured after being isolated from the JP-4 fuel underground storage tank, tank-lorry, water separator, and aircraft fuel tank. The effects of microbiological corrosion were examined on the specimens of 61-S aluminum alloy which was used in aircraft fuel tanks.The results were as follows:(1) Seventeen sorts of bacteria and three sorts of fungi were found to be bred by the utilization of JP-4 as nutritious element.(2) After culturing for 140 days, the surfaces of some aluminum specimens were covered with brown powdery blisters caused by the growth of microorganisms and other contaminations.(3) Severe corrosion pits were made on aluminum specimens, on which Micrococcus caseolyticus, Comamonas, and Vibrio faecalis were cultured.(4) It was observed that the surface of aluminum alloy specimens was covered with mycelium mats of Cladosporium resinae and tremendous corrosion existed under the mats.As the results, it is concluded that the preparation of filter-separator equipment such as ultrafine filter will be effective for the purpose of perfect removal of microorganisms from aircraft fuel.
著者
井上 真由美
出版者
一般社団法人 軽金属学会
雑誌
軽金属 (ISSN:04515994)
巻号頁・発行日
vol.18, no.9, pp.483-491, 1968-09-30 (Released:2008-10-30)
参考文献数
33

Aluminum corrosion induced by microbial contamination of jet fuel has become one of the most important troubles. The object of the present work is to study the corrosion of aluminum caused by the growth of fungi isolated from jet fuel system. Of the fungi isolated, Cladosporium resinae appeared to be the most predominant. Many kinds of filamentous fungi were obtained from slime of jet fuel, water layer of storage tank, and sludges on stringer and lower panel of integral fuel tank of YS-11 jet planeResults obtained were as follows.(1) After 330 day incubation, exfoliation and corrosion occurred with small blisters on the surface of aluminum alloy, 6061 specimen.(2) The cross section of the 6061 specimen indicated that the corrosion pits by Cladosporium resinae were extensively evident thoughout the aluminum body.(3) The specimens of high purity aluminum (1099 and 1100), anodized aluminum, and aluminum alloy 5052 were severely damaged by the attack of the fungus.(4) An extruded bar of 1100 was also attacked by Cladosporium resinae. Corrosion pits began to develop after 30 day culture of the fungus.(5) Large amounts of sludge deposits were found on the stringer and lower skin panel of the integral tank of YS-11 jet plane. Widespread corrosions were found in the area covered by the growth of the fungus.(6) Discussions were also made over the development of tests for the effects of protective coatings.
著者
井上 真由美
出版者
社団法人 腐食防食協会
雑誌
防蝕技術 (ISSN:00109355)
巻号頁・発行日
vol.16, no.11, pp.453-462, 1967-11-15 (Released:2009-11-25)
参考文献数
22