著者
原田 亜紀子 杉原 数美 渡部 容子 山路 誠一 北村 繁幸 太田 茂
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.135, no.10, pp.1185-1196, 2015 (Released:2015-10-01)
参考文献数
22

Aryl hydrocarbon receptor (AhR) ligand activity of the extracts of 62 herbal medicines was examined using yeast reporter assay. Fifty-eight herbal extracts exhibited AhR ligand activity. The highest activity was observed with Ogon (Scutellariae Radix), followed by Oren (Coptidis Rhizoma), Kujin (Sophorae Radix) and Shoma (Cimicifiigae Rhizoma). When these extracts were treated with hesperinase, a hydrolase for sugar conjugates, the aglycones showed higher activity than the parent extracts. Among the constituents of Ogon extract, baicalein and wogonin showed AhR ligand activity, while the sugar conjugate of baicalein, baicalin, was inactive. Among the flavonoid components of these herbal medicines, flavone and chrysin exhibited high ligand activity for AhR. Ethoxyresorufin O-dealkylase (EROD) activity due to CYP1A1 in HepG2 cells was enhanced by the addition of baicalein. Baicalein also decreased the 3-methylcholanthrene-induced increase of EROD activity, but this effect was not statistically significant. When wogonin or baicalein was orally administered at the dose of 100 mg/kg to mice, EROD activity in liver was only slightly changed. Furthermore, when Ogon extract was co-administered with 3-methylcholanthrene, the EROD and methoxyresorufin O-dealkylase activities were not significantly changed. These results indicate that many herbal extracts have AhR ligand activity, and their inducing effect on CYP1A1/2 can be evaluated in HepG2 cells.

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黄連解毒湯は黄連、黄柏、黄苓、山梔子の4種の生薬から構成。この中の黄連、黄柏、黄苓は転写因子のAhRを強く活性化させるから青黛と同じような作用、効果があるんじゃないかな...。UCの患者さんでは、この転写因子の活性が弱い。 https://t.co/YLm9jaJiur
例えば松本医院で処方されてる生薬の殆どに、AhRのリガンドとなり活性化する成分が含まれているので、免疫の恒常性維持を高めるから効果があるとか....。(´ー`) 62種生薬エキスのAhR受容体に対するリガンド活性 https://t.co/zQpLjv7UMD
漢方生薬エキス62種のうち58種でAhRリガンド活性。中でも黄芩 ,黄連,升麻が高活性。 https://t.co/kKrsXkGiaI

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