@drakchaurasia @Fangorn17 @DrLuana_ID @Acute_Pulmo_Med @richardursomd @andrejapi Tolvaptan likely indirectly reduces endothelin secretion. https://t.co/aPxWPVnn9M https://t.co/LVbr5M4gZM However, results in pulmonary arterial hypertension appear somewhat inconsistent. https://t.co/5N5JH2Mjkn https://t.co/4IqeVhYt5C (awkward to crop, see link) https://t.co/tWqcz2k5L7

@Dharmen46587056 @Thinkerks @nvaidyan @drakchaurasia @DrSubhasree @drharshvardhan @ProfBhargava @ICMRDELHI @PMOIndia @MoHFW_INDIA Mefenamic acid has particularly interesting antiplatelet effects. https://t.co/j2xWkIXWhU It likewise interferes with the antiplatelet effects of aspirin, though. It also seems to have some degree of broad-spectrum antiviral activity. Not sure of relative potency.

@mansarin Interesting studies: Prevents sepsis-like clotting in spite of NETs: https://t.co/x0hf91xBGr Reverses endothelial barrier dysfunction in anaphylaxis: https://t.co/JnxRA43kgJ May help in Ebola. 1mg/kg in rats produced 0.13μg/mL lung, 0.25μg/mL kidney. https://t.co/WRMhNXVnQu https://t.co/3WyQ4Ilcc6

Interferon alpha 2b: Chinese guidelines for COVID-19 have used 5 million IU IFN-α 2b, twice per day, nebulized in 2mL sterile water. https://t.co/4J1XNvK4ko https://t.co/H5UAyU4sde https://t.co/F0FFg625id https://t.co/g6j2kRe8VE https://t.co/vlPswac11E

Interferon alpha 2b: Chinese guidelines for COVID-19 have used 5 million IU IFN-α 2b, twice per day, nebulized in 2mL sterile water. https://t.co/4J1XNvK4ko https://t.co/H5UAyU4sde https://t.co/F0FFg625id https://t.co/g6j2kRe8VE https://t.co/vlPswac11E

@JoshBloomACSH Finally, please do not neglect the original large emergency clinical trial run in China across 10 hospitals: https://t.co/SgTMaQraJy Given the setting, data release has lagged, but the results led the Chinese government to make chloroquine the primary treatment for COVID-19.

@PhadingDark @RuskiBot762 Works in humans according to China. https://t.co/zpZ9um8OLA

@Rationalbot This is the main thing I have seen so far. The full results are not out yet. https://t.co/SgTMaQraJy

@BioinfoTools They seem to be in a rush to get the reports out the door. Not a huge amount of detail yet. But it does seem to work well enough that it has become one of the main drugs used in their official policies at this point. https://t.co/zpZ9ulRdn0

@boni_bo That said, there is significant within-generation regenerative potential evident in the germ lines of cloned animals. Makes me wonder in turn about any potential lifestyle or environmental factors that may affect germ line telomerase expression. https://t.co/TcsSRxVz6r

理論上は好中球エラスターゼ阻害剤とカテプシン阻害剤も同時に投与しないと抜け道になり得る。 カテプシンルートはだけはエンドソーム経由なのでそこターゲットにした阻害もあり。 4種類ともブロックしなきゃ！って言ってる人は見たことないから言ってみました〜 https://t.co/Yp6mn8GTc1

@darcyhall72 @Russ_Wilcox @__ice9 yes, ingredient available commercially in several brands as Quercetin EMIQ (Enzymatically Modified Isoquercitrin). Appears to be 17X more bioavailable than quercetin https://t.co/sNsoBNKy5z

In Japan, too, moderate alcohol drinking is associated with lowered mortality, despite a high prevalence of people with facial flushing response. https://t.co/wXM6BlPRt4 https://t.co/bpz2IkYLUp