著者

豊村 文将 渡嘉敷 亮二 平松 宏之 上田 百合 服部 和裕 高野 愛弓 渡嘉敷 邦彦

出版者

東京医科大学

雑誌

基盤研究(C)

巻号頁・発行日

2015-04-01

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痙攣性発声障害郡において前帯状皮質から基底核や中核言語領域への機能結合の増加を認めた。また、情動が痙攣性発声障害になんらからの関与をしている可能性が示唆された。その際、一般的に情動に最も関与しているとされる扁桃体よりも前帯状皮質からの関与が強く、それと線条体との機能結合が原因ではないかと考えられた。

著者

平澤 一浩 大塚 康司 伊藤 博之 上田 百合 白井 杏湖 鈴木 衞 永井 義幸 加藤 紀和 櫻井 衛

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.107, no.7, pp.529-533, 2014 (Released:2014-07-01)

参考文献数

20

被引用文献数

3

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Intranasal steroids are widely used to treat olfactory disorder, and are known to have fewer side effects than systemic steroids. However, there are some reports that intranasal steroids have induced adrenal insufficiency, even when the steroid dosage is appropriate. We encountered a case of secondary adrenal insufficiency after using intranasal betamethasone for olfactory disorder within the usual dosage. In this case, we were not aware of instructing the patient not to swallow the steroid which had dripped into her pharynx. Thus, a large amount of steroids which had passed through her nasal cavity might have been absorbed in the oropharyngeal mucosa and also ingested. That is possibly the main cause of developing adrenal insufficiency. Recently, Toki-shakuyaku-san, a traditional Chinese medicine, has started to be used for olfactory disorder after a cold. Because of its minimum side effects, it may be safely used for patients with the risk associated with steroid use.