3 0 0 0 OA シートベルトによる胸骨骨折
- 著者
- 中村 英次郎 井口 竹彦 中村 太郎 山田 秀大 七森 和久 酒井 祐一 林 義裕 畑田 和男
- 出版者
- West-Japanese Society of Orthopedics & Traumatology
- 雑誌
- 整形外科と災害外科 (ISSN:00371033)
- 巻号頁・発行日
- vol.47, no.2, pp.704-707, 1998-03-25 (Released:2010-02-25)
- 参考文献数
- 9
Five cases of the fracture of the sternum due to use of a seat belt were reported. According to the Fowler's classification, our cases were classified as TYPE: 1 case, Type IV: 3 cases and Type VIII: 1 case. With regard to four cases (type I and IV), the mechanism of the fracture was direct violence.A case associated with the injuries of interspinal ligaments of the thoracic spine, the mechanism of the fracture was indirect violence as flexion-compression injury. All cases were treated with rest and immobilization. The importance of radiographic examination on the sternum in patient of seat belt injury.
- 著者
- 佐々木 功 藤田 卓也 村上 正裕 山本 昌 中村 英次 今崎 一 村西 昌三
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.17, no.9, pp.1256-1261, 1994-09-15
- 被引用文献数
- 13 18
Absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, from the gastrointestinal (GI) tract was evaluated. The bioavailability of this compound after oral administration was considerably poor in rats. Studies were undertaken to elucidate the mechanisms for this low oral bioavailability of azetirelin. The plasma azetirelin levels following intravenous and hepatoportal vein injection were virtually identical over the dose range of 0.02-0.1 mg/kg, indicating a minor contribution of the hepatic first-pass metabolism of this drug. Azetirelin was stable against peptide hydrolases both in luminal fluid and intestinal mucosal homogenates, whereas its degradation occurred when incubated with cecal contents under an anaerobic condition. In addition, complete degradation of azetirelin during the GI transit was disclosed by analyzing the fecal sample collected after oral administration of [^<14>C] azetirelin. These results suggested that gut bacteria may be responsible for the hydrolysis of azetirelin in the GI tract. The low intestinal permeability of azetirelin was revealed by a modified everted gut experiment in various segments of the rat intestine. The poor membrane transport characteristics of azetirelin may be due to its high hydrophilicity. From these results, it was suggested that the insufficient oral bioavailability of azetirelin may be mainly attributed to its low intestinal permeability due to a lack of lipophilicity, and also to the degradation of the peptide by intestinal microflora.