著者

浜田 知久馬 中西 豊支 松岡 伸篤

出版者

日本計量生物学会

雑誌

計量生物学 (ISSN:09184430)

巻号頁・発行日

vol.27, no.2, pp.139-157, 2006-12-01 (Released:2011-09-25)

参考文献数

50

被引用文献数

4 3

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Meta-analysis is defined to be ‘the statistical analysis of a large collection of analysis results from individual studies for the purpose of integrating the findings'. Since the 1980s there has been an upsurge in the application of meta-analysis to medical research. The rapid increase in the number of meta-analysis being conducted during the last decade is mainly due to a greater emphasis on evidence based medicine and the need for reliable summaries of the vast and expanding volume of clinical studies. Over the same period there have been great developments and refinements of the associated methodology of meta-analysis. When judging the reliability of the results of a meta-analysis, attention should be focused on ‘publication bias’. Publication bias is the term for what occurs whenever the research that appears in the published literature is systematically unrepresentative of the population of completed studies. This bias can provide a flaw of the result of meta-analysis. In this article, the causes and origins of publication bias are reviewed, and then the history and some findings of publication bias in medical research are presented. Several statistical methods that have been developed to detect, quantify and assess the impact of publication bias in meta-analysis are demonstrated.

著者

中西 豊 竹内 英二 北野 博也 矢沢 代四郎 北嶋 和智

出版者

The Society of Practical Otolaryngology

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.89, no.4, pp.429-433, 1996-04-01

被引用文献数

3 1

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We treated a 20-year-old man with a blind bullet wound of the left temporal bone and perforating bullet wounds of the right temporal legion, the right upper arm and right femur.<br>Following physical examination, X-P, and CT, a bullet was detected in the left temporal bone. However, other wounds did not contain bullets. Emergency surgery was performed. The bullet was suspected to have entered through the posterior part of the mastoid tip, pass through the mastoid cavity and stopped at the tympanum. The facial canal was partially broken at the vertical portion, however the facial nerve was not damaged. The bullet was removed after resecting the posterior external auditory canal. Tympanoplasty type i combined with external canal wall drilling-down technique was performed.<br>The patient showed left facial palsy after surgery. However, this gradually improved. The postoperative course in his left ear was good without infection, although the patient was deaf in that ear.

著者

東山 智宣 中西 豊文 田窪 孝行

出版者

日本マイコトキシン学会

雑誌

マイコトキシン (ISSN:02851466)

巻号頁・発行日

vol.63, no.2, pp.209-216, 2013-07-31 (Released:2013-12-10)

参考文献数

8

被引用文献数

2 2

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マトリックス支援レーザー脱離イオン化飛行時間型質量分析法(Matrix-assisted laser desorption/ionization-time of flight mass spectrometry:MALDI-TOF MS)を用いた微生物同定法は,MS 法により得られた微生物特有のリボソームタンパク質を主成分とした分子のフィンガープリント(マススペクトルパターン)を,既知標準菌株ライブラリーと検索・照合し,目的菌種を同定する新手法である.従来法に比して特異性・迅速性に優れている.現在,我々の検査室では,主に臨床検体(血液,尿,糞便,喀痰等)から培養で発育した細菌や酵母様真菌の培地上のコロニーを対象に MALDI-TOF MS による微生物同定を実施している.一方,菌血症・敗血症等の起因菌を検出・同定検出する場合は,培養コロニーではなく,血液培養陽性培養液から直接同定する方法も検討している.今回,本法による微生物迅速同定の成績と感染症迅速診断への応用について概説する.