著者

那須 繁 山崎 昌典 宗 栄治 船越 健彦 岩谷 良一 井手 一馬 水田 由紀 井上 幹夫

出版者

公益社団法人 日本人間ドック学会

雑誌

健康医学 (ISSN:09140328)

巻号頁・発行日

vol.12, no.1, pp.61-64, 1997-05-30 (Released:2012-08-27)

参考文献数

9

被引用文献数

3

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人間ドックにおいて超音波を用いた甲状腺癌検診で,実受診者13.009名(のべ23,366名)中,38例の甲状腺癌が発見された。癌発見率は実受診者に対して0.29%(男性0.26%,女性0。33%)で,男性においても多数発見された。但し,甲状腺癌は頻度が高い劇に予後は良好であり,検診の目的や精検基準などを充分考慮して実施すべきと考えられる。

著者

鈴木 治 井上 幹夫

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.2, no.1, pp.34-39, 2000

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&nbsp;&nbsp;The previous study has shown that stainless steel surfaces on piping could greatly be subject to rouging during the operation of high-purity water systems (Suzuki O <i>et al.</i>: Pharm Tech <b>22</b>: 66-82, 1998). The follow-up study has hereupon been carried on to fed out what will potentially develop into such rouging on stainless steel, because the fouling-like rouging has always been an anxious matter to pharmaceutical engineers. The name of rouging is now given to a corrosive discoloration developed with various contaminants in the high-purity water treatment process, which will also occur in WFI (Water for Injection) systems or pure steam generators. Stainless steel elbow-piping sections, which surfaces were finished at such a high mill finish as mechanical polish and electropolish, were exposed to pure steam generated at 2 kg/cm²-g. The steam was also fed into the near-horizontal piping section not stagnant with distillate and the intentionally arranged section stagnant with distillate for 30 days. The inner surface after pure steam fed was visually inspected and analyzed by a physical technique of Auger electron spectroscopy so that rouging discoloration was detected to be mostly due to its surface oxidization of stainless steel. The oxidization is divided into two groups: namely, (1) reddish discoloration results from the vapor attack, and (2) blackish discoloration comes from long contact with condensate on stainless steel surfaces. The latter discoloration is further divided into two types in the chemical respect; namely, with carbon and without carbon. Although these kinds of discoloration may provide no deterioration for water quality because of very low solubility of metal oxides, a further study of this rouging mechanism should be made to acquire clear grounds for the final conclusion.<br>

著者

鈴木 治 井上 幹夫

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.2, no.1, pp.34-39, 2000 (Released:2006-08-01)

参考文献数

9

被引用文献数

1

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The previous study has shown that stainless steel surfaces on piping could greatly be subject to rouging during the operation of high-purity water systems (Suzuki O et al.: Pharm Tech 22: 66-82, 1998). The follow-up study has hereupon been carried on to fed out what will potentially develop into such rouging on stainless steel, because the fouling-like rouging has always been an anxious matter to pharmaceutical engineers. The name of rouging is now given to a corrosive discoloration developed with various contaminants in the high-purity water treatment process, which will also occur in WFI (Water for Injection) systems or pure steam generators. Stainless steel elbow-piping sections, which surfaces were finished at such a high mill finish as mechanical polish and electropolish, were exposed to pure steam generated at 2 kg/cm2-g. The steam was also fed into the near-horizontal piping section not stagnant with distillate and the intentionally arranged section stagnant with distillate for 30 days. The inner surface after pure steam fed was visually inspected and analyzed by a physical technique of Auger electron spectroscopy so that rouging discoloration was detected to be mostly due to its surface oxidization of stainless steel. The oxidization is divided into two groups: namely, (1) reddish discoloration results from the vapor attack, and (2) blackish discoloration comes from long contact with condensate on stainless steel surfaces. The latter discoloration is further divided into two types in the chemical respect; namely, with carbon and without carbon. Although these kinds of discoloration may provide no deterioration for water quality because of very low solubility of metal oxides, a further study of this rouging mechanism should be made to acquire clear grounds for the final conclusion.

著者

井上 幹夫

出版者

日本大腸肛門病学会

雑誌

日本大腸肛門病学会雑誌 (ISSN:00471801)

巻号頁・発行日

vol.45, no.6, pp.904-913, 1992 (Released:2009-12-03)

参考文献数

15

被引用文献数

12 9

著者

那須 繁 山崎 昌典 宗 栄治 船越 健彦 岩谷 良一 井手 一馬 水田 由紀 井上 幹夫

出版者

JAPAN SOCIETY OF NINGEN DOCK

雑誌

健康医学 : 日本人間ドック学会誌 (ISSN:09140328)

巻号頁・発行日

vol.12, no.1, pp.61-64, 1997-05-30

被引用文献数

1

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人間ドックにおいて超音波を用いた甲状腺癌検診で,実受診者13.009名(のべ23,366名)中,38例の甲状腺癌が発見された。癌発見率は実受診者に対して0.29%(男性0.26%,女性0。33%)で,男性においても多数発見された。但し,甲状腺癌は頻度が高い劇に予後は良好であり,検診の目的や精検基準などを充分考慮して実施すべきと考えられる。