著者

井上 敬介 浦山 由巳 上久木田 務 白井 俊光 白木澤 治 杉山 篤央 須藤 眞生 田中 広徳 田原 繁広 那須川 真澄 平原 茂人 堀江 匠 光吉 浩 三原 宏美 宮本 貴之 村上 大吉郎 山中 邦昭

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.17, no.1, pp.5-93, 2015 (Released:2015-08-12)

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This publication has been prepared to express a sound and practical view on the better manufacturing environmental control for non-sterile pharmaceutical dosage forms, which has been discussed for several years by a special working group members of Kansai Study Group (KSG) accredited as one of the committees in Parenteral Drug Association (PDA) Japan Chapter. The opinions proposed or advanced in the document are formed for the purpose of furnishing a beneficial and valuable guide with advisability to any persons or organizations concerned in establishing appropriate manufacturing control systems for quality products.   The leading topics discussed among the WG are focused on the prevention against cross-contamination and foreign matter ingress, and categorized into five subjects composed of HVAC systems, premises, gowning, cleaning, and cleanliness standards. Constructive and earnest discussion therein has been devoted to the key processes, wherein considerable amounts of powders are handled for the successful operations of weighing, granulation, mixing, and tableting. In the expectation of good usage, many of the principles and the way of thinking presented hereupon, in particular can be applied or rearranged to a wide spectrum of other manufacturing processes for various dosage forms of non-sterile drug products.

著者

井上 敬介

出版者

公益財団法人 史学会

雑誌

史学雑誌 (ISSN:00182478)

巻号頁・発行日

vol.117, no.6, pp.1122-1143, 2008-06-20 (Released:2017-12-01)

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The objective of the present article is to investigate the activities of the (Rikken-) Minsei Party (1927-1940) under Japan's national consensus governments of the 1930s, especially its extreme opposition to the claim that the will of the people was being usurped, leading to its refusal to form a government. To begin with, the author examines the process by which the Party decided upon a national consensus platform under the leadership of Wakatsuki Reijiro 若槻礼次郎. The Party's two main factions, led by Wakatsuki and Kawasaki Takukichi 川崎卓吉, respectively, reacted violently to the claim that that they had usurped the will of the people and chose to abandon any effort to form a partisan government. This claim came from the movement to reduce the sentences of the conspirators involved in the 15 May 1932 assassination of Prime Minister Inukai Tsuyoshi by a group of young naval officers, which held the Minsei Party responsible for the London Arms Limitations Treaty of 1930. On the other hand, the opposition faction formed within the Party by Ugaki Kazushige 宇垣一成 and Tomita Kojiro 富田幸次郎 took charge of movements to activate the party politics within the Diet and promote cooperation between the public and private sectors in attempts to find a way to form a Minsei Party government. Then the discussion turns to the efforts by Ugaki to form a new party from within after Wakatsuki stepped down in August 1934, followed by a wavering in the Party's national consensus line, and finally the establishment of such a platform under the leadership of Machida Chuji 町田忠治. The new party movement ended in failure after Ugaki's refusal to stand for party chairman, resulting in the election of Machida. Then leadership of the public-private sector cooperation movement was assumed by Kawasaki, while Tomita abandoned efforts to form a government. The 19^<th> party elections of 1936 pitted Tomita's call for partisan politics against Machida and Kawasaki's appeal for national consensus, as the Machida-Kawasaki line emerged victorious, from which time on, the Minsei Party made no further effort to form a partisan government in the world of Japanese politics following the 26 February 1936 coup d'etat attempt.

著者

井上 敬介

出版者

北海道大学

雑誌

北海道大学文学研究院紀要 (ISSN:24349771)

巻号頁・発行日

vol.162, pp.1-34, 2021-02-26

著者

平田 智之 井上 敬介 古川 大介 佐伯 壮一 塚原 義人

出版者

公益社団法人 日本生体医工学会

雑誌

生体医工学 (ISSN:1347443X)

巻号頁・発行日

vol.59, no.6, pp.169-173, 2021-12-10 (Released:2022-02-05)

参考文献数

10

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In recent years, the regenerative treatment of osteoarthritis (OA) by transplantation of autologous cultured cartilage has been developed, but biomechanical diagnostic evaluation of cartilage has not yet been performed in the follow-up after transplantation as well as typical OA diagnostic treatment. In this study, we constructed an Optical Coherence Doppler Velocigraphy (OCDV) system based on low coherence interferometer (OCT) and a compression tester as loading device, which can provide micro-tomographic visualization of tissue deformation and joint fluid flow inside cartilage tissue. The constructed system was applied to not only the normal sample of porcine knee cartilage but also the simulated degenerative one by collagenase enzyme treatment for 2 hours. As experimental results, during compression period, the both cartilage samples in the middle layer were observed to move toward surface, generating the compressive strain further in superficial layer. Doppler velocity of the degenerated cartilage was detected to be about 50µm/sec in the middle layer, which was twice as high as that of normal cartilage. Just after stress relaxation, Doppler velocity decreased immediately to be less than 5µm/sec in the normal cartilage, whereas are keeping about 10µm/sec in the degenerated one. These are considered to be due to the decrease in biomechanical properties, i. e. visco-elasticity, of degenerated cartilage. In conclusions, the proposed method can discriminate quantitatively between normal and OA cartilage from the spatiotemporal change of the detected Doppler velocity, in the virtue of revealing microscopic tissue deformation and joint fluid flow with high spatio-temporal resolution, therefore OCDV has an effective potential as a real-time diagnostic imaging system.

著者

井上 敬介

出版者

史学会 ; 1889-

雑誌

史学雑誌 (ISSN:00182478)

巻号頁・発行日

vol.126, no.10, pp.1612-1634, 2017-10

著者

井上 敬介

出版者

吉川弘文館

雑誌

日本歴史 (ISSN:03869164)

巻号頁・発行日

no.829, pp.54-69, 2017-06

著者

井上 敬介

出版者

大阪歴史学会

雑誌

ヒストリア = Historia : journal of Osaka Historical Association (ISSN:04392787)

巻号頁・発行日

no.262, pp.1-24, 2017-06